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F-Box Proteins

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A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.

Also Known As:

F-Box Domain Protein; F-Box Protein Family; Domain Protein, F-Box; F Box Domain Protein; F Box Protein Family; F Box Proteins; Protein Family, F-Box; Protein, F-Box Domain

Networked: 11 relevant articles (0 outcomes, 0 trials/studies) for this Bio-Agent, Comments

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 72216
  - Carrier Proteins: 9338
    - F-Box Proteins: 11

Experts

1.	Wei, Shuo: 1 article (01/2012)
2.	Kulp, Samuel K: 1 article (01/2012)
3.	Hung, Wen-Chun: 1 article (01/2012)
4.	Chu, Po-Chen: 1 article (01/2012)
5.	Chuang, Hsiao-Ching: 1 article (01/2012)
6.	Chen, Ching-Shih: 1 article (01/2012)
7.	Magori, Shimpei: 1 article (10/2011)
8.	Citovsky, Vitaly: 1 article (10/2011)
9.	Pagano, Michele: 1 article (06/2008)
10.	Frescas, David: 1 article (06/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "This Skp2-β-TrCP-Sp1 feedback loop represents a novel crosstalk mechanism between these two important F-box proteins in cancer cells with aberrant Skp2 expression under energy restriction, which provides a proof-of-concept that the oncogenic Csn5/Skp2 signaling axis represents a "druggable" target for this novel ERMA." 06/01/2005 - "Clinical evidence also suggests that dysregulation of these F-box proteins contributes to human cancers." 01/01/2000 - "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors." 06/01/2008 - "Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer." 06/01/2008 - "Here, we explore the functionality and biology of the F-box proteins, SKP2 (S-phase kinase-associated protein 2) and beta-TrCP (beta-transducin repeat-containing protein), which are emerging as important players in cancer biogenesis owing to the deregulated proteolysis of their substrates." Order ALL the reference details at left...
2.	Infection 10/18/2011 - "Many pathogens exploit the host SCF machinery to promote efficient infection by translocating pathogen-encoded F-box proteins into the host cell. " 01/01/2011 - "A recent bioinformatic analysis has identified more than 70 F-box proteins in 22 different bacterial species, suggesting that use of pathogen-encoded F-box effectors in the host cell may be a widespread infection strategy. " 01/01/2011 - "Increasing evidence indicates that such non-eukaryotic F-box proteins play an essential role in subverting or exploiting the host ubiquitin/proteasome system for efficient pathogen infection. " 10/01/2005 - "The large number of different poxviral ANK-F-box proteins suggests a wide range of cellular proteins might be subjected to ubiquitin-mediated degradation, thereby modulating diverse cellular responses to viral infection." Order ALL the reference details at left...
3.	Hepatocellular Carcinoma (Hepatoma) 09/01/2010 - "The F-box protein family member FBXO31 has rarely been studied in human hepatocellular carcinoma (HCC). " Order ALL the reference details at left...
4.	Breast Neoplasms (Breast Cancer) 05/12/2005 - "Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Ubiquitin
2.	Proteasome Endopeptidase Complex (Proteasome)
3.	beta-Transducin Repeat-Containing Proteins
4.	S-Phase Kinase-Associated Proteins (Skp1 Protein)
5.	Transcription Factor AP-1 (Transcription Factor AP 1)
6.	NF-kappa B (NF-kB)
7.	Proteins (Proteins, Gene)
8.	Ligases

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