Fibroblast Growth Factor-23

A specific fibrobroblast growth factor that is primarily synthesized by OSTEOCYTES and OSTEOBLASTS. It is involved in regulating phosphate homeostasis and renal phosphate excretion.

Also Known As:

Networked: 1753 relevant articles (19 outcomes, 196 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wolf, Myles: 87 articles (01/2022 - 07/2005)
2.	Isakova, Tamara: 49 articles (11/2022 - 07/2005)
3.	Fukumoto, Seiji: 38 articles (01/2022 - 07/2002)
4.	Jüppner, Harald: 30 articles (01/2020 - 02/2003)
5.	Ix, Joachim H: 26 articles (01/2022 - 03/2010)
6.	Gutiérrez, Orlando M: 24 articles (10/2021 - 08/2008)
7.	Fukagawa, Masafumi: 23 articles (01/2022 - 08/2004)
8.	White, Kenneth E: 22 articles (01/2022 - 04/2003)
9.	Salusky, Isidro B: 20 articles (11/2022 - 02/2009)
10.	Chonchol, Michel: 20 articles (01/2022 - 03/2011)

Related Diseases

1.	Chronic Renal Insufficiency 05/30/2022 - "Numerous clinical studies have indicated that elevated FGF23 (fibroblast growth factor 23) levels may be associated with cardiovascular (CV) mortality, especially in patients with chronic kidney disease. " 11/30/2021 - "This study evaluates bone mineral density (BMD) and trabecular bone score (TBS) in relationship with new markers of chronic kidney disease (CKD), fibroblast growth factor 23 (FGF23), and klotho. " 11/30/2021 - "This study evaluates bone mineral density (BMD) and trabecular bone score (TBS) in relationship with new markers of chronic kidney disease (CKD), fibroblast growth factor 23 (FGF23), and klotho. " 01/01/2021 - "Fibroblast growth factor 23 and new-onset chronic kidney disease in the general population: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study." 11/01/2018 - "NEW & NOTEWORTHY In the present study, we provide the first evidence that fibroblast growth factor 23 (FGF23) is a cause of peripheral endothelial dysfunction in a model of early chronic kidney disease (CKD) and that endothelial dysfunction in CKD can be prevented by blockade of FGF23. "
2.	Neoplasms (Cancer) 09/01/2017 - "Recently, several studies showed that systemic sampling of fibroblast growth factor 23 (FGF23) is helpful for localization of tumors. " 11/01/2023 - "Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm that causes tumor-induced osteomalasia (TIO) in most affected patients, usually through the production of fibroblast growth factor 23 (FGF23). " 02/28/2023 - "The most common cause of TIO is hypersecretion of tumor-derived fibroblast growth factor 23 (FGF23). " 11/01/2022 - "The cause is a mesenchymal tumor secreting fibroblast growth factor 23 (FGF23). " 10/01/2022 - "Serum fibroblast growth factor 23 was related to tumor size (r = 0.344, P < 0.001). "
3.	Hypophosphatemia 01/01/2022 - "The aim of this study was to fully describe the clinical and genetic characteristics, including clinical manifestations, intact fibroblast growth factor 23 (iFGF23) levels, and presence of PHEX gene mutations, of 22 and 7 patients with familial and sporadic X-linked dominant hypophosphatemia (XLH), respectively. " 08/01/2023 - "Her laboratory data showed hypophosphatemia and increased fibroblast growth factor 23 (FGF-23) together with reduced bone mineral density on bone densitometry. " 07/07/2023 - "Elevated serum fibroblast growth factor 23 (FGF23) level and hypophosphatemia indicated the diagnosis of TIO. " 03/01/2023 - "Evaluation of circulating fibroblast growth factor 23 (FGF23) concentrations plays a key role in the differential diagnosis of patients presenting with hypophosphatemia. " 11/01/2021 - "Measurement of fibroblast growth factor 23 (FGF23) has been reported to be clinically useful for the differential diagnosis of chronic hypophosphatemia. "
4.	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/01/2021 - "SIGNIFICANCE STATEMENT: This study used structure-based drug design and medicinal chemistry approaches to identify and optimize small molecules with different stability and potency, which antagonize excessive actions of fibroblast growth factor 23 (FGF23) in hereditary hypophosphatemic rickets. " 08/28/2023 - "The role of serum fibroblast growth factor 23 (FGF23) level in early neonatal period on the diagnosis of X-linked hypophosphatemic rickets (XLH) remains unclear. " 08/28/2023 - "Fibroblast growth factor 23 levels in cord and peripheral blood during early neonatal period as possible predictors of affected offspring of X-linked hypophosphatemic rickets: report of three female cases from two pedigrees." 10/01/2022 - "Current and Future Therapeutical Aspects of X-Linked Hypophosphatemia in Children With Special Attention to Klotho/Fibroblast Growth Factor 23 System." 01/01/2022 - "Upon workup, fibroblast growth factor 23 (FGF23) was noted to be relatively high in case 2 and serum phosphorous was low-normal in case 3, and the diagnoses of X-linked hypophosphatemic rickets (XLH) and ARHR2 were considered. "
5.	Fibrosis (Cirrhosis) 01/01/2022 - "Conclusions On the basis of these results, intact fibroblast growth factor 23 promotes CKD-induced myocardial fibrosis by activating the Shh signaling pathway." 01/01/2018 - "To investigate the role and mechanism of fibroblast growth factor 23 (FGF23) in renal interstitial fibrosis. " 07/08/2016 - "In aorta, these findings were accompanied by medial wall thickening, adventitial fibrosis, increased fibroblast growth factor 23 (FGF-23), decreased Klotho, enhanced oxidative stress, and endothelial cell ultrastructural changes, all of which were prevented with administration of LGT. " 01/01/2022 - "Intact Fibroblast Growth Factor 23 Regulates Chronic Kidney Disease-Induced Myocardial Fibrosis by Activating the Sonic Hedgehog Signaling Pathway." 01/01/2021 - "Excessive fibroblast growth factor 23 promotes renal fibrosis in mice with type 2 cardiorenal syndrome."

Related Drugs and Biologics

1.	Phosphates (Orthophosphate)
2.	Vitamin D
3.	burosumab
4.	Iron
5.	Phosphorus (Red Phosphorus)
6.	Parathyroid Hormone (Parathormone)
7.	Proteins (Proteins, Gene)
8.	ferric carboxymaltose
9.	Monoclonal Antibodies
10.	ferric citrate

Related Therapies and Procedures

1.	Therapeutics
2.	Renal Dialysis (Hemodialysis)
3.	Peritoneal Dialysis
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
5.	Kidney Transplantation