Nucleic Acid-Based Vaccines

Vaccines formulated with nucleic acids specific for a target antigen. They are designed to induce antibody production against the target by host.

Also Known As:

Nucleic Acid Based Vaccines; Vaccine, Nucleic Acid; Vaccine, Polynucleotide; Vaccines, Nucleic Acid; Vaccines, Nucleic Acid-Based; Vaccines, Polynucleotide; Nucleic Acid Vaccine; Nucleic Acid Vaccines; Polynucleotide Vaccine; Polynucleotide Vaccines

Networked: 108 relevant articles (15 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhu, Ping: 4 articles (12/2006 - 04/2002)
2.	Tan, Huo: 2 articles (06/2007 - 12/2006)
3.	Zhang, Lu: 2 articles (06/2007 - 12/2006)
4.	Liu, Hui: 2 articles (12/2006 - 01/2004)
5.	Zhang, Xin: 2 articles (06/2002 - 04/2002)
6.	Leitner, W W: 2 articles (11/2001 - 01/2000)
7.	Ying, H: 2 articles (01/2001 - 01/2000)
8.	Chou, C-T: 1 article (11/2022)
9.	Liao, H-T: 1 article (11/2022)
10.	Tsai, C-Y: 1 article (11/2022)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2001 - "Despite highly promising results in many animal tumor models the efficacy of nucleic acid vaccines and adjuvants in the clinic remains to be seen." 11/30/2022 - "Enhancing the Effect of Nucleic Acid Vaccines in the Treatment of HPV-Related Cancers: An Overview of Delivery Systems." 03/01/2022 - "Today, an unprecedented understanding of the cancer genome, along with major breakthroughs in oncoimmunotherapy, and a resurgence of nucleic acid vaccines against cancer are being achieved. " 07/01/2000 - "In comparison to lacZ-transfected tumor cells as vaccines, polynucleotide vaccination also demonstrated superiority with regard to cross-protection. " 07/01/1999 - "'Naked' nucleic acid vaccines are potentially useful candidates for the treatment of patients with cancer, but their clinical efficacy has yet to be demonstrated. "
2.	Communicable Diseases (Infectious Diseases) 06/01/1997 - "International Meeting on Nucleic Acid Vaccines for the Prevention of Infectious Diseases. " 10/31/2023 - "Nucleic acid vaccines have shown promising results in the clinic against infectious diseases and cancers. " 01/01/2000 - "Indeed, data from human clinical trials is scant: nucleic acid vaccines have not been clearly demonstrated to have any convincing efficacy in the prevention or treatment of infectious disease or cancer. " 01/01/2021 - "Faced with the challenges posed by infectious diseases and cancer, nucleic acid vaccines present excellent prospects in clinical applications. " 01/01/2021 - "A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications."
3.	Infections 12/01/2023 - "An Integrated in silico and in vivo study of nucleic acid vaccine against Nocardia seriolae infection in orange-spotted grouper Epinephelus coioides." 10/01/2000 - "Macrophages are normal targets for Salmonella during natural infections, and it has been demonstrated that attenuated bacteria can deliver nucleic acid vaccine constructs. " 08/20/1999 - "Since induction of immunity at mucosal surfaces (route of entry for many pathogens) is critical to prevent infection, various methods of delivering polynucleotide vaccines to mucosal surfaces have been attempted and are described. " 06/01/1997 - "The deficient infant cellular immune responses, responsible for their susceptibility to infections with intracellular pathogens, could possibly benefit from the potential of nucleic acid vaccines to trigger strong TH1-like responses. " 11/01/2022 - "Nucleic acid-based vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are effective in the general population. "
4.	Parasitic Diseases (Parasitic Disease) 02/01/1995 - "These results suggest that nucleic acid vaccine is effective against parasite infections." 08/01/1997 - "In the future, nucleic acid vaccines will be a useful tool to help control these and other parasitic infections." 01/01/1999 - "Further, we discuss safety issues, and document the use of nucleic acid vaccines against viral, bacterial and parasitic diseases, and cancer. " 01/01/2004 - "DNA or nucleic acid vaccines are being evaluated for efficacy against a range of parasitic diseases. " 07/01/2001 - "Development of nucleic acid-based vaccines against parasitic diseases shows great promise, although certain concerns about safety aspects of conventional DNA vaccines have been raised. "
5.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2019 - "In this study, NgR and PirB were selected to construct a double-targeted granulocyte-macrophage colony stimulating factor-NgR-PirB (GMCSF-NgR-PirB) nucleic acid vaccine, and investigate the efficacy of this immunotherapy in a spinal cord injury model in rats. " 01/01/2019 - "Nucleic Acid Vaccine Targeting Nogo-66 Receptor and Paired Immunoglobulin-Like Receptor B as an Immunotherapy Strategy for Spinal Cord Injury in Rats."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Vaccines
3.	RNA (Ribonucleic Acid)
4.	Autoantigens
5.	Recombinant Proteins
6.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
7.	Proteins (Proteins, Gene)
8.	CPG-oligonucleotide
9.	DNA Vaccines
10.	Antigens

Related Therapies and Procedures

1.	Immunotherapy
2.	Hematopoietic Stem Cell Transplantation
3.	Therapeutics