mRNA Vaccines

Vaccines formulated with recombinant mRNAs which are taken up by the host cells that translate the mRNA and present the translated proteins to the immune system as antigens in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigen.

Also Known As:

RNA Vaccine; mRNA Vaccine; RNA Vaccine, Self-Amplifying; Self Amplifying RNA Vaccine; Vaccine, RNA; Vaccine, Self-Amplifying RNA; Vaccine, mRNA; Vaccine, saRNA; Vaccine, taRNA; Vaccines, RNA; Messenger RNA Vaccines; Naked RNA Vaccines; RNA Vaccines; Self-Amplifying RNA Vaccine; Trans Amplifying RNA Vaccine; saRNA Vaccine; taRNA Vaccine

Networked: 2786 relevant articles (264 outcomes, 349 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gaglani, Manjusha: 23 articles (10/2022 - 01/2021)
2.	Verani, Jennifer R: 22 articles (10/2022 - 07/2021)
3.	Schrag, Stephanie J: 19 articles (10/2022 - 07/2021)
4.	Talbot, H Keipp: 17 articles (05/2022 - 12/2020)
5.	Weissman, Drew: 15 articles (01/2022 - 01/2017)
6.	Patel, Manish M: 14 articles (10/2022 - 07/2021)
7.	Sahin, Ugur: 14 articles (06/2022 - 10/2011)
8.	Pardi, Norbert: 14 articles (01/2022 - 01/2017)
9.	Kwon, Jennie H: 13 articles (10/2022 - 07/2021)
10.	Martin, Emily T: 13 articles (10/2022 - 07/2021)

Related Diseases

1.	COVID-19 01/01/2022 - "Consistent with results from randomized trials and observational studies in other populations, mRNA vaccines were highly effective in preventing SARS-CoV-2 infections among incarcerated people. " 08/18/2021 - "Consistent with results from randomized trials and observational studies in other populations, mRNA vaccines were highly effective in preventing SARS-CoV-2 infections among incarcerated people. " 08/04/2023 - "Most importantly, mRNA vaccines have been highly efficacious in avoiding serious disease and death from COVID-19. " 01/06/2023 - "Coronavirus disease 2019 (COVID-19), which spread worldwide from Wuhan, China, in 2019, appeared for a time to be overcome by the remarkable efficacy of mRNA vaccines; however, new variants of severe acute respiratory syndrome coronavirus 2 have emerged and remain rampant. " 01/01/2023 - "COVID-19 mRNA vaccines have been highly effective in preventing serious illness, hospitalization, and death. "
2.	Infections 01/01/2021 - "Randomized controlled trials have shown that mRNA vaccines are highly effective in preventing SARS-CoV2 infection. " 01/01/2023 - "In Japan, where most are infection-naïve, and strict prevention measures are maintained regardless of vaccination status, 2-dose mRNA vaccines provided high protection against symptomatic infection during the Delta-dominant period and moderate protection during the Omicron-dominant period. " 01/01/2022 - "Among an older, mostly male, population with comorbidities, we found that an mRNA vaccine booster was highly effective against infection, hospitalisation and death. " 01/01/2022 - "Although mRNA vaccines against SARS-CoV-2 were highly efficacious against severe illness and hospitalization, they seem to be less effective in preventing infection months after vaccination, especially with the Delta variant. " 10/12/2021 - "While mRNA vaccines are proving highly efficacious against SARS-CoV-2, it is important to determine how booster doses and prior infection influence the immune defense they elicit, and whether they protect against variants. "
3.	Neoplasms (Cancer) 01/01/2021 - "SARS-CoV-2 mRNA vaccines are highly effective in the general population; however, few data are available on their efficacy in patients with cancer. " 06/01/2022 - "A third mRNA vaccine dose significantly improved humoral responses among patients with plasma cell disorders, whereas the effect was limited among patients with B-cell malignancies." 10/01/2023 - "By understanding the potential of mRNA vaccines in addressing the unmet medical need of gastrointestinal tumors, we aim to pave the way for improved treatment strategies and better patient outcomes." 01/01/2022 - "The mRNA vaccines have been considered effective for combating cancer. " 01/01/2021 - "mRNA vaccines against cancer have advantages in safety, improved therapeutic efficacy, and large-scale production. "
4.	Breakthrough Infections 11/21/2023 - "To address this, we investigate antibody responses in 72 participants given three doses of a monovalent mRNA vaccine, followed by a bivalent or monovalent booster, or those with breakthrough infections with BA.5 or BQ. " 03/15/2023 - "Effect of a Fourth Dose of mRNA Vaccine and of Immunosuppression in Preventing SARS-CoV-2 Breakthrough Infections in Heart Transplant Patients." 01/01/2023 - "Lower T cell response against SARS-CoV-2 variants of concern after mRNA vaccine and risk of breakthrough infections in people with HIV." 01/01/2023 - "We report that Omicron BA.4/BA.5 breakthrough infection of individuals immunized with SARS-CoV-2 wild-type-strain-based mRNA vaccines results in a boost of Omicron BA.4.6, BF.7, BQ.1.1, and BA.2.75 neutralization but does not efficiently boost BA.2.75.2, XBB, or XBB.1.5 neutralization. " 01/01/2023 - "Impaired SARS-CoV-2 Variant Neutralization and CD8+ T-cell Responses Following 3 Doses of mRNA Vaccines in Myeloma: Correlation with Breakthrough Infections."
5.	Communicable Diseases (Infectious Diseases) 11/22/2023 - "Systematic literature review of clinical and immunologic studies of mRNA vaccines against infectious diseases. " 11/01/2023 - "Thus, although further studies and evaluation of the subject are necessary, it is evident that RNA vaccines can be considered a promising alternative in the treatment and prophylaxis of infectious diseases." 11/01/2023 - "Therefore, this systematic review aimed to evaluate the use of RNA vaccines for infectious diseases from experimental, in vivo, and in vitro studies. " 01/01/2022 - "Herein we highlight the prospect of developing oral replicon-based mRNA vaccines against infectious diseases based on our recent primary studies on SARS-CoV-2. " 01/01/2021 - "This will draw attention to various mRNA vaccines against infectious diseases that are in the early stages of clinical trials. "

Related Drugs and Biologics

1.	Vaccines
2.	Messenger RNA (mRNA)
3.	BNT162 Vaccine
4.	COVID-19 Vaccines
5.	RNA (Ribonucleic Acid)
6.	Antigens
7.	mRNA Vaccines
8.	Antibodies
9.	2019-nCoV Vaccine mRNA-1273
10.	Neutralizing Antibodies

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