Viral Zoonoses

Viral infections that may be transmitted between non-human animals and HUMANS.

Also Known As:

Disease, Viral Zoonotic; Diseases, Viral Zoonotic; Infection, Viral Zoonotic; Infection, Zoonotic Viral; Infections, Viral Zoonotic; Infections, Zoonotic Viral; Viral Infection, Zoonotic; Viral Infections, Zoonotic; Viral Zoonose; Viral Zoonotic Infection; Viral Zoonotic Spillover; Viral Zoonotic Spillovers; Zoonose, Viral; Zoonoses, Viral; Zoonosis, Viral; Zoonotic Disease, Viral; Zoonotic Diseases, Viral; Zoonotic Infection, Viral; Zoonotic Infections, Viral; Zoonotic Spillovers, Viral; Zoonotic Viral Infection; Viral Zoonosis; Viral Zoonotic Disease; Viral Zoonotic Diseases; Viral Zoonotic Infections; Zoonotic Spillover, Viral; Zoonotic Viral Infections

Networked: 41 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Mpox (monkeypox)
3.	Rabies (Hydrophobia)
4.	Smallpox (Variola)
5.	Carcinogenesis

Experts

1.	Rupprecht, Charles E: 2 articles (11/2021 - 01/2020)
2.	Martin, Thibaud: 1 article (06/2022)
3.	Ratnadass, Alain: 1 article (06/2022)
4.	Durairajan, Siva Sundara Kumar: 1 article (01/2022)
5.	Huang, Jian-Dong: 1 article (01/2022)
6.	Jeewon, Rajesh: 1 article (01/2022)
7.	Namachivayam, Mayurikaa: 1 article (01/2022)
8.	Saravanan, Udhaya Bharathy: 1 article (01/2022)
9.	Bauer, Sarah: 1 article (11/2021)
10.	Linhardt, Robert J: 1 article (11/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Viral Zoonoses:

1.	VaccinesIBA 01/01/2021 - "Individual protection, contact tracing, and lockdown have proved to be just partially effective to respond to the spillover of viral zoonosis into the human population, and for most of these pathogens, vaccines are not yet available. " 01/25/2022 - "There is a critical need to develop animal models to alleviate vaccine and drug development difficulties against zoonotic viral infections. " 10/01/2021 - "The strategy in which RVFV infectious clones are rescued in Vero cells and then subsequently amplified in MRC-5 cells will support the vaccine seed lot systems of live-attenuated recombinant RVFV vaccines for human use.IMPORTANCE RVF is a mosquito-transmitted, viral, zoonotic disease endemic to Africa and the Arabian Peninsula, and its spread outside of the endemic area will potentially cause devastating economic damages and serious public health problems. " 01/01/2018 - "Baited vaccines: A strategy to mitigate rodent-borne viral zoonoses in humans." 01/01/2021 - "rabies is a vaccine-preventable viral zoonotic disease. "
2.	AntibodiesIBA 08/23/2021 - "All healthy humans have high levels of natural anti-α-galactosyl (α-Gal) antibodies (elicited by yet uncharacterized glycotopes), which may play important roles in immunoglycomics: (a) potential protection against certain parasitic and viral zoonotic infections; (b) targeting of α-Gal-engineered cancer cells; (c) aiding in tissue repair; and (d) serving as adjuvants in α-Gal-based vaccines. " 02/01/2017 - "Bats are recognized carriers of emerging viral zoonoses and have been proposed as dengue reservoirs, since RNA/NS1 and/or antiviral antibodies have been detected. "
3.	Bone Marrow Stromal Antigen 2IBA 11/01/2011 - "Ancient origin of a deletion in human BST2/Tetherin that confers protection against viral zoonoses." 02/01/2009 - "Overall, these data indicate that tetherin could impose a barrier to viral zoonosis as a consequence of positive selection that has been driven by ancient viral antagonists, and that the HIV-1 Vpu protein has specialized to target the transmembrane domains found in human/chimpanzee tetherin proteins."
4.	3- (2- methoxyphenyl)- 5- methoxy- 1,3,4- oxadiazol- 2(3H)- oneIBA 12/01/2023 - "Mpox is an ongoing viral zoonotic disease epidemic worldwide. " 12/01/2023 - "Mpox is a viral zoonosis with endemic circulation in animals and humans in some West and Central African countries. " 01/01/2023 - "Mpox is a viral zoonotic disease endemic in Central and West Africa that is caused by the Mpox virus, which belongs to the Orthopoxvirus genus and Poxviridae family. " 10/01/2023 - "Monkeypox (MPOX) is a viral zoonosis endemic in West or Central African countries that is sporadically exported to another area. " 06/12/2023 - "Monkeypox (Mpox) is a zoonotic viral infection endemic to Africa, which has caused a global outbreak since April 2022. "
5.	DNA (Deoxyribonucleic Acid)IBA 01/01/2023 - "Monkeypox is a viral zoonotic disease caused by the monkeypox virus, a double-stranded DNA-enveloped virus that can be transmitted from animal to human or human to human. " 11/01/2022 - "Monkeypox is a viral zoonosis caused by the monkeypox virus, an enveloped, double-stranded DNA virus belonging to the Orthopoxvirus genus in the Poxviridae family. " 06/01/2022 - "Monkeypox is a viral zoonotic disease caused by MPXV, which is an enveloped, linear, double-stranded DNA virus belonging to the Orthopoxvirus genus, of the Chordopoxvirinae subfamily, within the Poxviridae family. " 08/01/2023 - "Monkeypox (Mpox) is a viral zoonotic disease caused by the Mpox virus, part of the Orthopoxvirus (OPXV) genus, which is a family of double-stranded DNA viruses. "
6.	Rabies Vaccines (Rabies Vaccine)FDA Link 01/01/2013 - "Rabies vaccine has proven to be the most effective weapon for coping with this fatal viral zoonotic disease of warm-blooded animals, including human. " 11/01/2021 - "While the developed world has rolled back dog-mediated human rabies, thanks to social interventions and modern rabies vaccines, African and Asian countries still struggle with a significant burden due to this viral zoonosis. " 01/01/2020 - "Human rabies, a neglected viral zoonosis, is preventable through domestic animals vaccination and post-exposure prophylaxis using inactivated rabies vaccines. "
7.	Antiviral Agents (Antivirals)IBA 01/01/2021 - "The COVID-19 crisis has emphasised the need for antiviral therapies to combat current and future viral zoonoses. " 07/01/2008 - "Covered topics included: General Virology and Viral Genetics, Medical Virology and Antiviral Therapy, Viral Biotechnologies and Gene Therapy, Viral Oncogenesis and Vaccines, Virus-Host Interactions and Pathogenesis, Emerging and Zoonotic Viral Infections. " 02/01/2017 - "Bats are recognized carriers of emerging viral zoonoses and have been proposed as dengue reservoirs, since RNA/NS1 and/or antiviral antibodies have been detected. "
8.	RNA (Ribonucleic Acid)IBA 09/01/2020 - "Crimean-Congo Haemorrhagic Fever (CCHF) is an increasingly relevant viral zoonosis caused by the negative-sense single-stranded (ss) RNA Crimean-Congo Haemorrhagic Fever Orthonairovirus (CCHFV) (Nairoviridae family, Bunyavirales order). " 02/01/2017 - "Bats are recognized carriers of emerging viral zoonoses and have been proposed as dengue reservoirs, since RNA/NS1 and/or antiviral antibodies have been detected. "
9.	Proteins (Proteins, Gene)FDA Link 04/13/2011 - "Viral zoonosis, the transmission of a virus from its primary vertebrate reservoir species to humans, requires ubiquitous cellular proteins known as receptor proteins. " 02/01/2009 - "Overall, these data indicate that tetherin could impose a barrier to viral zoonosis as a consequence of positive selection that has been driven by ancient viral antagonists, and that the HIV-1 Vpu protein has specialized to target the transmembrane domains found in human/chimpanzee tetherin proteins."
10.	Small Interfering RNA (siRNA)IBA 04/01/2016 - "Together, these experiments demonstrate that the TG mice are less permissive for influenza virus replication, and suggest that shRNA-based efficient disruption of viral gene expression in animals may be a useful strategy for prevention and control of a viral zoonosis. "

Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation) 01/01/2016 - "Humanized pigs have been developed to reduce the incidence of immune rejection in xenotransplantation, but significant concerns remain, such as transmission of viral zoonosis. " 04/01/2008 - "Strategies to enhance the safety profile of xenotransplantation: minimizing the risk of viral zoonoses."
2.	Therapeutics 01/01/2021 - "The COVID-19 crisis has emphasised the need for antiviral therapies to combat current and future viral zoonoses. " 07/01/2008 - "Covered topics included: General Virology and Viral Genetics, Medical Virology and Antiviral Therapy, Viral Biotechnologies and Gene Therapy, Viral Oncogenesis and Vaccines, Virus-Host Interactions and Pathogenesis, Emerging and Zoonotic Viral Infections. "
3.	Transplantation 01/01/2016 - "The observed risk of PERV zoonosis highlights the requirement for thorough evaluation of viral zoonosis under particular host conditions, such as immunosuppressive treatment and transplantation with host-adapted virus-producing cells."
4.	Transcutaneous Electric Nerve Stimulation (TENS) 01/01/2020 - "Caused by pathogens in the family Rhabdoviridae, genus Lyssavirus, and distributed globally, this viral zoonosis results in tens of thousands of human fatalities and millions of exposures annually. "