3C Viral Proteases

A class of cysteine proteases which play an essential role in VIRUS REPLICATION. They cleave precursor viral POLYPROTEINS to produce functional proteins and enzymes. In addition, they cleave certain host cell proteins such as EUKARYOTIC INITIATION FACTOR-4G.

Also Known As:

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lloyd, Richard E: 2 articles (05/2008 - 03/2002)
2.	Lord, Etienne: 1 article (01/2022)
3.	Sanfaçon, Hélène: 1 article (01/2022)
4.	Xiao, Huogen: 1 article (01/2022)
5.	Dufour, Antoine: 1 article (01/2018)
6.	Jagdeo, Julienne M: 1 article (01/2018)
7.	Jan, Eric: 1 article (01/2018)
8.	Kizhakkedathu, Jayachandran: 1 article (01/2018)
9.	Kleifeld, Oded: 1 article (01/2018)
10.	Klein, Theo: 1 article (01/2018)

Related Diseases

1.	Infections 05/25/2008 - "Only about half of cellular PABP is cleaved by viral 2A and 3C proteinases during infection. " 01/01/1999 - "Here, we show that PABP is specifically degraded during poliovirus infection and that it is cleaved in vitro by both poliovirus 2A and 3C proteases and coxsackievirus B3 2A protease. " 09/08/1997 - "The picornavirus 3C proteases are required for the processing of viral polyproteins during infections of host cells. " 12/15/2016 - "This study demonstrates that both 2A and 3C proteases are required for the correct localization of proteins during infection and defines the temporal regulation of 2A and 3CD/3C protease activities during HRV16 infection."
2.	Virus Diseases (Viral Diseases) 01/01/2018 - "N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection." 01/01/2022 - "Picornavirus 3C proteases cleave hundreds of host proteins to facilitate virus infection. " 03/01/2002 - "These results suggest that 3C(pro) plays a major role in processing PABP during virus infection and that the interaction of PABP with translation initiation factors, ribosomes, or poly(A) RNA may promote its cleavage by viral 2A and 3C proteases."
3.	Severe Acute Respiratory Syndrome 03/01/2006 - "The 3C-like protease of the severe acute respiratory syndrome (SARS) coronavirus has a C-terminal extra domain in addition to the chymotrypsin-fold adopted by picornavirus 3C proteases hosting the complete catalytic machinery. "
4.	Poliomyelitis (Polio) 09/15/1990 - "The substrate recognition properties of the polio-virus type 1 and coxsackievirus B3 3C proteinases have been examined in vitro by allelic and suballelic exchange of 3C between the cloned virus genomes. "
5.	Hepatitis A (Hepatitis, Infectious) 09/08/1997 - "It was also determined that the hepatitis A and encephalomyocarditis virus 3C proteases compete with each other for conjugation with ubiquitin and for degradation. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Peptide Hydrolases (Proteases)
3.	Polyproteins
4.	Adenovirus Vaccines
5.	Ubiquitin
6.	Messenger RNA (mRNA)
7.	Peptide Initiation Factors (Initiation Factor)
8.	Chymotrypsin
9.	rupintrivir