Polycyclic Sesquiterpenes

Sesquiterpenes that contain two or more ring structures

Also Known As:

Derivative, Caryophyllane; Derivative, Eremophilane; Derivative, Valerane; Derivatives, Caryophyllane; Derivatives, Eremophilane; Derivatives, Valerane; Sesquiterpene, Polycyclic; Sesquiterpenes, Polycyclic; Caryophyllane; Caryophyllane Derivative; Caryophyllane Derivatives; Caryophyllanes; Eremophilane; Eremophilane Derivative; Eremophilane Derivatives; Eremophilanes; Polycyclic Sesquiterpene; Valerane; Valerane Derivative; Valerane Derivatives; Valeranes

Networked: 9 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Di Giacomo, Silvia: 3 articles (06/2022 - 10/2020)
2.	Di Sotto, Antonella: 3 articles (06/2022 - 10/2020)
3.	Gullì, Marco: 3 articles (06/2022 - 10/2020)
4.	Eufemi, Margherita: 2 articles (06/2022 - 10/2020)
5.	Mancinelli, Romina: 2 articles (06/2022 - 10/2020)
6.	Facchinetti, Roberta: 1 article (06/2022)
7.	Minacori, Marco: 1 article (06/2022)
8.	Percaccio, Ester: 1 article (06/2022)
9.	Scuderi, Caterina: 1 article (06/2022)
10.	Bai, Laxinamujila: 1 article (05/2022)

Related Diseases

1.	Malaria 07/01/2008 - "Artemisinin is a polycyclic sesquiterpene lactone that is highly effective against multidrug-resistant strains of Plasmodium falciparum, the etiological agent of the most severe form of malaria. "
2.	Hypoxia (Hypoxemia) 05/01/2022 - "Eremophilane and Cadinene Sesquiterpenes from Syringa oblata and Their Protective Effects against Hypoxia-Induced Injury on H9c2 Cells."
3.	Neoplasms (Cancer) 06/14/2022 - "Present findings strengthen the interest in caryophyllane sesquiterpenes as chemosensitizing and chemopreventive agents and contribute to clarifying drug resistance mechanisms in HCC, CCA, and PDAC cancers and to developing possible novel therapeutic strategies." 05/01/2017 - "The aim of this research was to determine the cytotoxic action of sixteen structurally-related eremophilane-type sesquiterpenes, isolated from several species of Senecio, against a panel of cancer cell lines. " 10/18/2020 - "Emerging evidence has outlined a complex polypharmacological profile of caryophyllane sesquiterpenes characterized by blocking, suppressing, chemosensitizing, and cytoprotective properties, which suggests a possible usefulness of these natural substances in cancer chemoprevention for both preventive and adjuvant purposes. " 09/01/2004 - "07H239-A (1), a new eremophilane sesquiterpene from a marine-derived xylariaceous fungus, was isolated, characterized, and shown to be cytotoxic toward a variety of cancer cell lines, with some selectivity for a CCRFCEM leukemia line (IC(50) = 0.9 microg/mL)." 11/05/2021 - "Particularly, their cytotoxicity was evaluated in different cancer cell lines, and the possible entourage effect between nonintoxicating phytocannabinoids (cannabidiol and cannabichromene) and caryophyllane sesquiterpenes (β-caryophyllene, β-caryophyllene oxide and α-humulene), as identified at GC/MS analysis, was characterized. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 06/14/2022 - "Sorafenib Chemosensitization by Caryophyllane Sesquiterpenes in Liver, Biliary, and Pancreatic Cancer Cells: The Role of STAT3/ABC Transporter Axis."
5.	Leukemia 09/01/2004 - "07H239-A (1), a new eremophilane sesquiterpene from a marine-derived xylariaceous fungus, was isolated, characterized, and shown to be cytotoxic toward a variety of cancer cell lines, with some selectivity for a CCRFCEM leukemia line (IC(50) = 0.9 microg/mL)."

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Lactones
3.	artemisinin (artemisinine)
4.	ATP-Binding Cassette Transporters (ABC Transporters)
5.	Cannabidiol
6.	Sorafenib (BAY 43-9006)
7.	caryophyllene oxide
8.	07H239-A
9.	3-butyl-7-hydroxyphthalide
10.	fomannoxin

Related Therapies and Procedures

1.	Chemoprevention
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)