Eremophilane and Cadinene Sesquiterpenes from Syringa oblata and Their Protective Effects against Hypoxia-Induced Injury on H9c2 Cells.

Abstract

Seven sesquiterpenes including four eremophilanes (1-4) and three cadinenes (5-7), were isolated from the heartwood of Syringa oblata Lindl. Among them, three new eremophilane-type sesquiterpenes were identified and named oblatanoids A-C (1-3), respectively. Their structures were established by extensive analyses of spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. All these new compounds were evaluated for protective effects against hypoxia-induced injury on H9c2 cells, and 1-3 exhibited significantly protective activities toward H9c2 cells in vitro.

• Authors: Badalahu Tai, Laxinamujila Bai, Muyao Yu, Juan Liu, Han Zheng, Luqi Huang
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 19 Issue 5 Pg. e202200154 (May 2022) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 35417623 (Publication Type: Journal Article)
• Copyright: © 2022 Wiley-VHCA AG, Zurich, Switzerland.

Chemical References

• Polycyclic Sesquiterpenes
• Sesquiterpenes

Topics

• Circular Dichroism
• Hypoxia
• Molecular Structure
• Polycyclic Sesquiterpenes (pharmacology)
• Sesquiterpenes (chemistry, pharmacology)
• Syringa (chemistry)