Toxic Optic Neuropathy

03/01/1987 - "This study suggests that Arden contrast sensitivity plates would be effective in detecting subclinical toxic optic neuropathy due to ethambutol and therefore could be used for routine monitoring of ocular function of patients on ethambutol. "
11/01/2021 - "This study aimed to identify the lower dose of daily ethambutol that can reduce ocular toxicity. "
12/01/2003 - "Ethambutol induced ocular toxicity was seen in three patients (10%) in our study. "
07/01/1980 - "[Study of the ocular toxicity of ethambutol]."
03/01/1978 - "[Prevention of ocular toxicity of ethambutol: study of zincaemia and chromatic analysis (author's transl)]."

01/01/2020 - "The RMA identified 11 studies considering ocular toxicity as a side effect of hydroxychloroquine and estimated the incidence to be 3.4% (95% CI 1.11%-9.96%). "
01/01/2013 - "The objective of this study is to review the published data on ocular toxicity in newborns after in utero exposure to hydroxychloroquine. "
03/01/2004 - "The present study demonstrates a lack of conformity to national guidelines in respect of the monitoring of ocular toxicity of hydroxychloroquine. "
03/01/2004 - "The present study shows that nationally set guidelines for the monitoring of ocular toxicity of hydroxychloroquine are not consistently followed by rheumatologists with regard to baseline assessment, referral to ophthalmology and frequency of monitoring. "
07/01/2020 - "To assess the ocular toxicity in patients on high doses of hydroxychloroquine (HCQ) per weight, as per the latest American Academy of Ophthalmology (AAO) screening guidelines for HCQ toxicity. "

01/01/1981 - "[Ultrastructural and experimental study of the ocular toxicity of antibiotics and antifungals on the corneal endothelium (author's transl)]."
10/01/2018 - "We review the literature on the prevalence, clinical manifestations, and management of antibiotic induced toxic optic neuropathies. "
10/01/2018 - "Mitochondrial Impairment in Antibiotic Induced Toxic Optic Neuropathies."
12/01/2001 - "Antibiotics have the potential to cause significant ocular toxicity when they gain access to the inside of the eye. "
01/01/1980 - "Cephaloridine is an antibiotic well known for its remarkable efficacy and absence of ocular toxicity. "

04/01/2022 - "Collectively, our results suggest that specific retinal layers, which may be targeted by specific toxins, are beneficial in identifying genes responsible for drug-induced ocular toxicity."
01/01/2022 - "Main outcome measures were resolution or decreased subretinal fluid on OCT, visual stability or improvement, lack of retinal/ocular toxicity. "
12/01/2021 - "To verify formulation's safety for ophthalmic use, preparation was tested for potential ocular toxicity using a cell viability assay on retinal cells. "
08/20/2021 - "NN2101 neither caused ocular toxicity nor interfered with the early retinal vascular development in mice. "
01/01/2021 - "Post-treatment characterization of RGCs (optic nerve axon counts/density, and grading), retinal function (electroretinography), and retinal histology revealed that photocrosslinking was associated with some ocular toxicity. "

09/01/1983 - "Effect of therapeutic agents on acute ocular toxicity of methyl alcohol (an experimental study)."
04/01/2021 - "We presented herein a procedure to identify and manage toxic optic neuropathy caused by methanol inhalation. "
04/01/2021 - "Conclusions: Methanol-induced toxicity can cause a non-reversible toxic optic neuropathy. "
04/01/2021 - "Purpose: To describe a clinical case of toxic optic neuropathy with severe visual loss caused by inhalation abuse of methanol products. "
09/01/2020 - "Acute methanol exposure leads to systemic intoxication and toxic optic neuropathy. "

04/01/2014 - ", recently, some clinical studies have shown that ocular toxicity in patients treated with eye drops containing BAC has not apparent correlated with BAC.Some"
01/01/2023 - "To determine the drop volume and total number of dispensed drops using the Nanodropper eyedrop bottle adaptor (Nanodropper, Inc.) compared to drops dispensed from stock bottles to potentially limit ocular toxicity of these eyedrops and prolong bottle use. "
01/01/2022 - "Cytotoxicity analysis using HCECs revealed that the IC50 was 250 µg/ml. Safety analyses in healthy SD rats showed that Mino eye drops did not demonstrate any ocular toxicity. "
12/01/2020 - "This finding highlights the importance of considering the combined ocular toxicity of BAK and solar radiation in the risk assessment of BAK-preserved ophthalmic solutions."
12/01/2014 - "Twenty-four rabbits were randomly divided into 8 groups (n = 3): The ocular toxicity at 14 d after eye drop ad- ministration was evaluated in groups 1 to 4, and at 30 d post- administration in groups 5 to 8. Groups 1 and 5 were treated with blank vehicle and served as normal controls. "

06/10/1987 - "Ocular toxicity of low dose cytosar."
12/01/1983 - "Subconjunctival versus intravenous cytosine arabinoside: effect of route of administration and ocular toxicity."
02/01/1983 - "Prior and subsequent administration of cytosine arabinoside according to the same dose schedule for only four doses over two days and eight doses over four days were well tolerated and did not produce ocular toxicity. "
02/01/1983 - "Ocular toxicity from high-dose cytosine arabinoside."
03/01/1999 - "Our procedure in this study would be effective for the prevention of ocular toxicity in the high-dose Ara-C therapy."

09/01/2021 - "Effects of Achillea millefolium on cisplatin induced ocular toxicity: an experimental study."
01/01/1996 - "However, cisplatin exposure was 1.2-fold higher in patients with ocular toxicity compared with control subjects. "
03/01/2005 - "[Toxic optic neuropathy due to cisplatin therapy: a case report]."
09/01/2021 - "Aim: Cisplatin is a widely used and highly effective anti-cancer agent and one of the limiting side effects of cisplatin is ocular toxicity. "
09/01/2021 - "Moreover, we observed that Achillea millefolium restored ocular histopathological structure and significantly suppressed apoptosis by reducing the expression of Caspase-3.Conclusion: Collectively, our results suggest that Achillea millefolium have protective effects against cisplatin-induced ocular toxicity and is a promising adjuvant therapy with the potential to prevent cisplatin related ocular toxicity."

07/01/2018 - "Previous small-molecule and biologic MEK inhibitors demonstrated ocular toxicity events that were dose limiting in clinical studies. "
07/01/2018 - "Ocular Toxicity Profile of ST-162 and ST-168 as Novel Bifunctional MEK/PI3K Inhibitors."
02/01/2016 - "MEK inhibitors: a new class of chemotherapeutic agents with ocular toxicity."
01/01/2016 - "Special attention has been drawn to the inhibitors of the MEK signaling pathway, due to their sine qua non ocular toxicity, defined as MEK retinopathy and described as symmetrical bilateral disease that develops in a time-dependent and dose-dependent manner. "
08/01/2015 - "Discontinuation or decreased dosing of MEK inhibitors may be reserved for cases of severe sight-threatening ocular toxicity. "

07/01/2004 - "There is no high-level evidence that low-to-medium-dose inhaled corticosteroids have ocular toxicity or important effects on hypothalamic-pituitary-adrenal function in children. "
11/15/1991 - "Corticosteroid-induced toxic optic neuropathy."
02/01/2001 - "The manifestations of the ocular toxicity of systemic corticosteroids include posterior subcapsular cataracts and glaucoma. "
01/01/2019 - "This study investigated the underlying mechanisms of ocular toxicity and evaluated primary prophylactic use of corticosteroid eye drops in patients receiving mirvetuximab soravtansine. "
05/01/2023 - "Ocular toxicity is a known class effect of some ADCs and is managed with prophylactic corticosteroid and vasoconstrictor eye drops as well as dose interruptions/holds and dose modifications. "

01/01/2022 - "A166 was withheld if ≥G2 ocular toxicity developed; if status improved to ≤G1, A166 therapy was resumed. "
01/01/2018 - "Such ocular toxicity is manifest clinically as ocular surface disease (OSD) and has been confirmed in epidemiologic, prospective clinical trials and studies in which patients are switched from preservative-added to preservative-free topical therapy. "
02/01/2006 - "Others have reported ocular toxicity after adjuvant chemoendocrine therapy, but this study looked at ocular toxicity in similarly treated patients from large randomized clinical trials. "
07/01/2023 - "In this article, we provide an updated review of treatment-emergent ocular toxicity associated with new and novel oncologic therapies and summarize guidelines and best practice strategies for prevention, monitoring and management. "
01/01/2023 - "This has impaired the development of effective therapies to treat the acute and long-term ocular toxicity of CP. "

04/01/2022 - "Microarray-based gene expression analysis combined with laser capture microdissection is beneficial in investigating the modes of action of ocular toxicity."
01/01/2018 - "Intravitreal amodaiquine significantly reduced choroidal neovascularization (CNV) lesion volume in the laser-induced CNV mouse model, and showed no signs of ocular toxicity at the highest doses tested. "
01/01/2022 - "The study aimed to assess the ocular toxicity of hydroxychloroquine (HCQ) by confocal microscopy, multifocal electroretinography (mfERG), and scanning laser polarimetry with variable corneal compensation (GDxVCC) in patients with rheumatoid arthritis (RA). "
01/01/2015 - "We report three cases suggesting that bull's eye maculopathy seen on near-infrared reflectance with a confocal scanning laser ophthalmoscope could be an early, objective manifestation of hydroxychloroquine ocular toxicity, and with progression of the disease this near-infrared "bull's eye" change may disappear. "

03/01/1991 - "Development of improved hydrogels for soft intraocular lenses, based on 2-hydroxyethyl methacrylate monomer, requires the use of various other monomers and polymerization additives which have potential ocular toxicity. "

07/01/1991 - "Cerebral or ocular toxicity unique to this method of chemotherapy administration and failure to show clinical improvement were the most common reasons for removal from study. "
06/01/2018 - "Ocular toxicity induced by anticancer chemotherapy is not uncommon, but underestimated and under-reported. "
01/01/2018 - "Patients having chemotherapy induced ocular toxicity should go for ophthalmic examination to pick up ocular adverse effects of anticancer drugs and treat them at an early stage."
04/01/2017 - "Ocular toxicity is an uncommon complication of cytotoxic chemotherapy. "
01/01/2017 - "With the advent of more aggressive cytotoxic chemotherapy regimens, the incidence of ocular toxicity due to these drugs is also on the rise. "

03/01/2021 - "They also caused negligible ocular toxicity/abnormalities up to 28 days post-intravitreal injection in mice. "
08/01/2015 - "Management of the ocular toxicity can range from observation to topical treatments or intravitreal injections. "
08/01/2012 - "Following enucleation, ocular toxicity and the presence or absence of viable tumour cells at the intravitreal injection site were recorded. "
01/01/2017 - "These data demonstrate a lack of tolerability of PLGA microspheres upon intravitreal injection, and suggest that the size, shape, and/or surface area of PLGA depots are critical attributes in determining ocular toxicity."
01/01/2020 - "Ocular toxicity studies revealed that intravitreal injection of griseofulvin in adult mice does not disrupt retinal vasculature, function, or morphology. "