Abstract | BACKGROUND: Others have reported ocular toxicity after adjuvant chemoendocrine therapy, but this study looked at ocular toxicity in similarly treated patients from large randomized clinical trials. METHODS: RESULTS:
Ocular toxicity was reported in 538 of 4948 (10.9%) patients during adjuvant treatment, mainly during chemotherapy. Forty-five of 4948 (0.9%) patients had ocular toxicity during hormone therapy alone, but only 30 (0.6%) patients had ocular toxicity reported either without receiving any chemotherapy or beyond 3 months after completing chemotherapy and, thus, possibly related to tamoxifen or toremifene. In 3 cases, retinal alterations, without typical aspects of tamoxifen toxicity, were reported; 4 patients had cataract (2 bilateral), 12 impaired visual acuity, 10 ocular irritation, 1 optical neuritis, and the rest had other symptoms. CONCLUSION:
Ocular toxicity during adjuvant therapy is a common side effect mainly represented by irritative symptoms due to chemotherapy. By contrast, ocular toxicity during hormonal therapy is rare and does not appear to justify a regular program of ocular examination. However, patients should be informed of this rare side effect so that they may seek prompt ophthalmic evaluation for ocular complaints.
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Authors | Lorenzo Gianni, Ilaria Panzini, Sigui Li, Richard D Gelber, John Collins, Stig B Holmberg, Diana Crivellari, Monica Castiglione-Gertsch, Aron Goldhirsch, Alan S Coates, Alberto Ravaioli, International Breast Cancer Study Group (IBCSG) |
Journal | Cancer
(Cancer)
Vol. 106
Issue 3
Pg. 505-13
(Feb 01 2006)
ISSN: 0008-543X [Print] United States |
PMID | 16369994
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2005 American Cancer Society. |
Chemical References |
- Antineoplastic Agents, Hormonal
- Tamoxifen
- Toremifene
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Topics |
- Aged
- Antineoplastic Agents, Hormonal
(adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy)
- Databases, Factual
- Eye
(drug effects)
- Eye Diseases
(chemically induced)
- Female
- Humans
- Male
- Middle Aged
- Randomized Controlled Trials as Topic
- Retrospective Studies
- Tamoxifen
(adverse effects)
- Toremifene
(adverse effects)
- Visual Acuity
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