Polyprenols

06/01/2018 - "Polyprenols treatment significantly improved cognitive impairment of double transgenic mice compared with vehicle control treatment in behavioral tests. "
06/01/2018 - "Polyprenols mitigate cognitive dysfunction and neuropathology in the APP/PS1 mouse."
01/01/2014 - "Polyprenols have a significant relieving effect on learning, memory, and spontaneous activities in a D-galactose-induced mouse model and ameliorates cognitive impairment and biochemical dysfunction in mice. "
01/01/2014 - "Effects of polyprenols from pine needles of Pinus massoniana on ameliorating cognitive impairment in a D-galactose-induced mouse model."
01/01/2014 - "In summary, we have demonstrated that polyprenols may ameliorate memory and cognitive impairment via enhancing oxidative defense and affecting generation and dissimilation of Aβ-related enzymes, suggesting that polyprenols represent a novel drug for treating Alzheimer's disease."

07/01/2002 - "Basing on all these data we proposed that polyprenols could be considered as a "label" which grants a possibility to the innate immune system to recognize infection at the early stages and govern the acquired immunity."
05/01/2000 - "Effect of intramuscularly injected polyprenols on influenza virus infection in mice."
05/01/2000 - "This study demonstrates the possibility of achieving a prophylactic effect by intramuscular injection of Abies sibirica polyprenols for the control of influenza virus infection in mice. "
05/01/2000 - "These data indicate that emulsions of polyprenols that have relatively low hydrophilic-lipophilic balance, inhibit influenza virus infection in mice through a modulation of the host immune response."
11/01/2001 - "[Prophylactic efficacy of aerosol preparations based on Abies siberica polyprenols in experimental influenza infection]."

01/01/2016 - "Recent pre-clinical studies have shown treatment with polyprenols from conifers had a range of neurological and cognitive effects, including improved cognitive performance in a rat model relevant to Alzheimer's disease and healthy levels of myelination in mice with an experimental model of multiple sclerosis. "
01/01/1985 - "Long-chain polyisoprenoid alcohols (dolichols) were measured in different brain regions dissected postmortem from 26 histopathologically confirmed cases of Alzheimer's disease and 24 age-matched nonAlzheimer control patients. "
01/01/2014 - "In summary, we have demonstrated that polyprenols may ameliorate memory and cognitive impairment via enhancing oxidative defense and affecting generation and dissimilation of Aβ-related enzymes, suggesting that polyprenols represent a novel drug for treating Alzheimer's disease."

01/01/2016 - "Recent pre-clinical studies have shown treatment with polyprenols from conifers had a range of neurological and cognitive effects, including improved cognitive performance in a rat model relevant to Alzheimer's disease and healthy levels of myelination in mice with an experimental model of multiple sclerosis. "
05/01/2019 - "Plant polyprenols reduce demyelination and recover impaired oligodendrogenesis and neurogenesis in the cuprizone murine model of multiple sclerosis."

05/01/2001 - "Preventive effect in influenza can be attained by intramuscular injections of fir (Abies) polyprenols. "
03/19/2015 - "In order to improve the bioavailability levels of polyprenols (derived from ginkgo leaves (GBP)) in the human body, a GBP nanoemulsion was prepared, and its antiviral activity was evaluated against influenza A H3N2 and hepatitis B virus in vitro. "
03/19/2015 - "Antiviral activity of a nanoemulsion of polyprenols from ginkgo leaves against influenza A H3N2 and hepatitis B virus in vitro."
01/01/2005 - "A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols."
11/01/2001 - "[Prophylactic efficacy of aerosol preparations based on Abies siberica polyprenols in experimental influenza infection]."