A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols.

Abstract

This research investigates a promising antiviral compound based on polyprenols from Siberian silver fir (Abies sibirica). The physico-chemical characteristics of a preparation developed in aerosol form and an estimation of its protective efficacy against aerosol challenge of laboratory animals are presented. It is shown that (1) by using a simple ultrasonic disperser one can obtain aerosol of three formulations studied with about 70% of its mass accumulated in the size range below 1.8 microm; (2) 40-100% of aerosol particles contain preparation for different formulations; (3) after delivering under specified schedules, the preparations as developed can protect up to 100% of mice against 5 LD(50) of influenza A/Aichi/2/68 (H3N2) virus aerosol infection. Animals inhaled twice the preparation doses (which were 100 times lower than injection ones of the same efficacy) and did not exceed 10 microg/mouse. It was shown that the mode of action of this immunomodulating preparation was nonspecific stimulation of immune cells' various activities.

• Authors: A S Safatov, A N Boldyrev, L E Bulychev, G A Buryak, T P Kukina, V D Poryvaev, O V P'yankov, V A Raldugin, A B Ryzhikov, A N Sergeev, L N Shishkina, G A Tolstikov, V A Zhukov
• Journal: Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine (J Aerosol Med) Vol. 18 Issue 1 Pg. 55-62 ( 2005) ISSN: 0894-2684 [Print] United States
• PMID: 15741774 (Publication Type: Journal Article)

Chemical References

• Aerosols
• Antiviral Agents
• Plant Preparations

Topics

• Abies
• Aerosols
• Animals
• Antiviral Agents (therapeutic use)
• Female
• Influenza A virus
• Male
• Mice
• Nebulizers and Vaporizers
• Orthomyxoviridae Infections (prevention & control)
• Phytotherapy
• Plant Preparations