Retinal Arterial Macroaneurysm

An acquired dilation of the retinal artery often associated with systemic HYPERTENSION.

Also Known As:

Arteriolar Macroaneurysm, Retinal; Macroaneurysm, Retinal; Macroaneurysm, Retinal Arterial; Macroaneurysm, Retinal Arteriolar; Retinal Arterial Macroaneurysms; Retinal Arteriolar Macroaneurysms; Retinal Macroaneurysms; Retinal Arteriolar Macroaneurysm; Retinal Macroaneurysm; Ruptured Retinal Arterial Macroaneurysm

Networked: 127 relevant articles (10 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Macular Degeneration (Age-Related Maculopathy)
3.	Pain (Aches)
4.	Retinal Perforations
5.	Retinal Vein Occlusion

Experts

1.	Tsujikawa, Akitaka: 3 articles (03/2022 - 06/2009)
2.	Kadomoto, Shin: 2 articles (03/2022 - 09/2021)
3.	Murakami, Tomoaki: 2 articles (03/2022 - 09/2021)
4.	Muraoka, Yuki: 2 articles (03/2022 - 09/2021)
5.	Ooto, Sotaro: 2 articles (03/2022 - 09/2021)
6.	Chatziralli, Irini: 2 articles (12/2021 - 03/2017)
7.	Bandello, Francesco: 2 articles (03/2021 - 09/2020)
8.	Pierro, Luisa: 2 articles (03/2021 - 04/2012)
9.	Cho, Han Joo: 2 articles (01/2021 - 05/2013)
10.	Kim, Jong Woo: 2 articles (01/2021 - 05/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Retinal Arterial Macroaneurysm:

1.	Tissue Plasminogen Activator (Alteplase)FDA Link 04/01/2015 - "[Findings of Optical Coherence Tomography (OCT) in Submacular Haemorrhage Displacement Due to a Retinal Macroaneurysm by Intravitreal Injection of Gas and Recombinant Tissue Plasminogen Activator (rtPA)]." 09/01/1998 - "Submacular surgery with tissue plasminogen activator-assisted thrombolysis achieved improved best-corrected visual acuity in eyes with recent submacular hemorrhage involving the center of the fovea associated with retinal arterial macroaneurysm." 02/01/2005 - "To assess the efficacy of treating submacular hemorrhages secondary to retinal arterial macroaneurysm with intravitreous tissue plasminogen activator (tPA) and gas. " 10/01/2015 - "Subretinal injection of recombinant tissue plasminogen activator for submacular hemorrhage associated with ruptured retinal arterial macroaneurysm." 11/01/2012 - "Treatment of multilevel macular hemorrhage secondary to retinal arterial macroaneurysm with submacular tissue plasminogen activator."
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/01/2021 - "Hemodynamic and structural changes in retinal arterial macroaneurysm after intravitreal anti-vascular endothelial growth factor injection." 06/01/2019 - "INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS FOR EXUDATIVE RETINAL ARTERIAL MACROANEURYSMS." 09/01/2017 - "Laser and Anti-Vascular Endothelial Growth Factor Agent Treatments for Retinal Arterial Macroaneurysm." 04/01/2013 - "Intravitreal anti-VEGF therapy for retinal macroaneurysm." 04/01/2013 - "Intravitreal anti-vascular endothelial growth factor therapy appears to be a promising treatment alternative to laser treatment in cases of retinal macroaneurysms with macular exudation."
3.	Retinaldehyde (Retinal)IBA 06/01/2009 - "To study the retinal structural changes associated with a retinal arterial macroaneurysm and their association with visual prognosis. " 03/01/2022 - "These images suggest the pathogenesis of retinal arterial macroaneurysm (RAM) associated with crack-like changes in the retinal arterial wall, similar to pathologies seen in systemic arteries." 02/01/2019 - "Retinal arteriolar macroaneurysm associated with congenital retinal macro vessel." 01/01/2017 - "In contrast to retinal arterial macroaneurysms, retinal venous macroaneurysms are quite rare. " 09/01/2009 - "The authors present a patient who had an unusually large retinal arteriolar macroaneurysm in conjunction with a congenital retinal macrovessel."
4.	Ranibizumab (Lucentis)FDA Link 01/01/2020 - "A rare case of ruptured optic disc retinal arterial macroaneurysm and its successful management with intravitreal ranibizumab." 03/10/2017 - "To evaluate the potential efficacy and safety of primary intravitreal ranibizumab in patients with symptomatic retinal arterial macroaneurysm (RAM). " 03/10/2017 - "Intravitreal ranibizumab for retinal arterial macroaneurysm: long-term results of a prospective study." 01/01/2015 - "To evaluate the anatomic and functional results of intravitreal ranibizumab injection for treatment of symptomatic retinal arterial macroaneurysm (RAM). " 08/01/2011 - "Ranibizumab for retinal arterial macroaneurysms."
5.	Bevacizumab (Avastin)FDA Link 01/01/2014 - "Intravitreal bevacizumab for symptomatic retinal arterial macroaneurysm." 05/01/2013 - "Intravitreal bevacizumab injection could be an effective treatment option for symptomatic retinal arterial macroaneurysm." 05/01/2013 - "Intravitreal bevacizumab for symptomatic retinal arterial macroaneurysm." 04/01/2013 - "Intravitreal bevacizumab for macular complications from retinal arterial macroaneurysms." 04/01/2013 - "Intravitreal bevacizumab for macular complications from retinal arterial macroaneurysms. "
6.	Fluorescein (Funduscein)FDA LinkGeneric 03/01/2021 - "Optical coherence tomography-angiography and fluorescein angiography were important to determine the nature of the lesion, identified as a congenital retinal arterial macroaneurysm. " 11/01/2016 - "Symptomatic retinal arterial macroaneurysms (RAM) are primarily investigated by fundus fluorescein angiography after presenting with visual disturbance. " 11/01/2010 - "Fluorescein angiography demonstrated closure of the retinal macroaneurysm at 6-week follow-up. " 08/01/2009 - "A diagnosis of retinal arterial macroaneurysm was given after fluorescein angiography and evaluation by a retina specialist. " 06/01/2008 - "of fluorescein angiography or indocyanine angiography, associated with ultrasound, OCT and several other examinations were analyzed in 22 patients (22 eyes) with retinal arterial macroaneurysm. "
7.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 12/01/1998 - "The study was carried out to describe the indocyanine green angiographic findings in isolated primary retinal arterial macroaneurysms and their contribution to the diagnosis of this condition. " 12/01/1998 - "Indocyanine green angiography in isolated primary retinal arterial macroaneurysms." 01/01/1997 - "Indocyanine green videoangiography of hemorrhagic retinal arterial macroaneurysms." 02/01/1995 - "Detection of retinal arterial macroaneurysms with indocyanine green videoangiography." 01/01/2000 - "In five eyes of five patients, indocyanine green angiography demonstrated acquired retinal arterial macroaneurysms as the cause of hemorrhage. "
8.	KH902 fusion proteinIBA 10/27/2023 - "Hemorrhagic retinal arterial macroaneurysm combined with branch retinal artery occlusion treated with intravitreal conbercept injection: A case report." 01/15/2019 - "The purpose of this study is to describe the clinical efficacy of intravitreal ranibizumab or intravitreal conbercept for retinal arterial macroaneurysm. " 01/15/2019 - "Intravitreal ranibizumab or conbercept might be used as a therapeutic option for symptomatic retinal arterial macroaneurysm patients. " 01/15/2019 - "Intravitreal ranibizumab or conbercept for retinal arterial macroaneurysm: a case series."
9.	ArgonIBA 01/01/2001 - "Dense premacular hemorrhage from a retinal macroaneurysm treated by argon laser." 01/01/2000 - "Dense premacular hemorrhage from a retinal macroaneurysm treated by argon laser." 01/01/2000 - "Dense premacular hemorrhage from a retinal macroaneurysm treated by argon laser." 11/01/2010 - "Functional and morphological data at baseline and at 4 weeks, 3 months, and 5 months after the initiation of therapy with two intravitreal ranibizumab (Lucentis®) injections followed by focal argon laser coagulation surrounding the retinal macroaneurysm are presented. "
10.	afliberceptIBA 01/01/2017 - "Intravitreal aflibercept for ruptured retinal arterial macroaneurysm." 02/01/2021 - "[Retinal arterial macroaneurysm and anti-Vascular Endothelial Growth Factor (aflibercept) in Eales's disease: A case report]." 01/01/2020 - "The left eye was lost in the course of the disease, whereas the right eye developed a persistent macular edema due to multiple leaking retinal arterial macroaneurysms and responded poorly to intravitreal ranibizumab and only partially to intravitreal aflibercept. "

Therapies and Procedures

1.	Lasers (Laser) 03/01/2021 - "To report the changes over time in ocular blood flow quantified by laser speckle flowgraphy (LSFG) in a treated large retinal arterial macroaneurysm (RAM). " 03/01/2021 - "Evaluation of ocular blood flow over time in a treated retinal arterial macroaneurysm using laser speckle flowgraphy." 08/01/2017 - "To describe the advantages of en face view with swept-source optical coherence tomography in assessing the morphologic features of retinal arterial macroaneurysms, their consequences on adjacent retina, planning laser treatment, and evaluating its effects. " 04/02/2012 - "Subthreshold laser treatment versus threshold laser treatment for symptomatic retinal arterial macroaneurysm." 04/01/2011 - "To assess the effects of subthreshold laser treatment (STLT) for retinal arterial macroaneurysms (RAM) associated with foveal exudative manifestations and visual acuity deterioration. "
2.	Vitrectomy 09/01/2010 - "Retinal arterial macroaneurysm was revealed during vitrectomy. " 06/01/1999 - "[Role of vitrectomy in the treatment of retinal arterial macroaneurysms]." 08/01/1993 - "Pars plana vitrectomy for complications of retinal arterial macroaneurysms--a case series." 11/01/2006 - "The surgical excision of retinal macroaneurysms might be an effective procedure in cases where the macroaneurysm is too large or cannot be treated by photocoagulation during vitrectomy." 03/01/2000 - "Pars plana vitrectomy appears to be relatively safe and effective in treating massive macular hemorrhage caused by a retinal arterial macroaneurysm."
3.	Therapeutics 06/01/2019 - "There is no established therapy for exudative-hemorrhagic complications in primary retinal arteriolar macroaneurysm (RAM). " 10/01/2015 - "Long-term, therapy-related visual outcome of 49 cases with retinal arterial macroaneurysm: a case series and literature review." 09/01/2014 - "[Retinal Arterial Macroaneurysms (RAM)--pathology, differenzial diagnoses, and therapy]." 01/01/1988 - "[Clinical aspects and therapy of retinal macroaneurysms]." 12/01/2016 - "Photocoagulation is an effective therapy to control retinal macroaneurysms and nonperfusions and to prevent visual loss, particularly in the early stages of IRVAN syndrome (stages 2 & 3). "
4.	Light Coagulation 09/01/2010 - "While photocoagulation of retinal arterial macroaneurysm on the optic disc is infrequently used to, localized photocoagulation retinal arterial macroaneurysm on the optic disk is considered to be difficult. " 05/01/2019 - "A 21-year-old female with bilateral IRVAN syndrome-stage 2 in the right eye and stage 3 in the left eye-previously treated bilaterally with laser photocoagulation for retinal macroaneurysms and ischemic areas between 1985 and 1992. " 01/01/2018 - "To compare the efficacy and safety of conventional and navigated laser photocoagulation as the primary treatment option for retinal arteriolar macroaneurysm (RAM). " 01/01/2018 - "Direct navigated laser photocoagulation as primary treatment for retinal arterial macroaneurysms." 12/01/2016 - "Photocoagulation is an effective therapy to control retinal macroaneurysms and nonperfusions and to prevent visual loss, particularly in the early stages of IRVAN syndrome (stages 2 & 3). "
5.	Intravitreal Injections 01/01/2010 - "Eighteen patients were treated with ppV, intravitreal injection of rtPA and 20% SF6 gas [group A: mean age 78 years, mean duration of symptoms 6.6 days, 15 age-related macular degeneration (AMD), three retinal arterial macroaneurysm (RAMA)]. " 08/01/2011 - "Submacular hemorrhage was related to exudative age-related macular degeneration (AMD) in 39 eyes and ruptured retinal arterial macroaneurysms in 14 eyes, and treated with intravitreal injection of SF(6) gas with or without tPA. " 04/01/2015 - "[Findings of Optical Coherence Tomography (OCT) in Submacular Haemorrhage Displacement Due to a Retinal Macroaneurysm by Intravitreal Injection of Gas and Recombinant Tissue Plasminogen Activator (rtPA)]." 09/01/2017 - "To describe the efficacy of laser and intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents for patients with symptomatic retinal arterial macroaneurysm (RAM). " 12/01/2019 - "To report the possible complications of intravitreal injection of tissue plasminogen activator (t-PA) for the treatment of submacular hemorrhage associated with retinal arterial macroaneurysm (RAM). "