8-Hydroxy-2'-Deoxyguanosine

Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.

Also Known As:

8-OH-dG; 8-oxo-dG; 8-oxo-dGuo; 8-oxodG; 8-oxodGuo; 2' Deoxy 7,8 Dihydro 8 Oxoguanosine; 2' Deoxy 8 Hydroxyguanosine; 2' Deoxy 8 Oxo 7,8 Dihydroguanosine; 2' Deoxy 8 Oxoguanosine; 7 Hydro 8 Oxodeoxyguanosine; 7,8 Dihydro 8 Oxo 2' Deoxyguanosine; 8 Hydroxy 2' Deoxyguanosine; 8 Hydroxydeoxyguanosine; 8 Oxo 2' Deoxyguanosine; 8 Oxo 7 Hydrodeoxyguanosine; 8 Oxo 7,8 Dihydro 2' Deoxyguanosine; 8 Oxo 7,8 Dihydrodeoxyguanosine; 8 Oxo Deoxyguanosine; 2'-Deoxy-7,8-Dihydro-8-Oxoguanosine; 2'-Deoxy-8-Hydroxyguanosine; 2'-Deoxy-8-Oxo-7,8-Dihydroguanosine; 2'-Deoxy-8-Oxoguanosine; 7,8-Dihydro-8-Oxo-2'-Deoxyguanosine; 7-Hydro-8-Oxodeoxyguanosine; 8-Hydroxydeoxyguanosine; 8-Oxo-2'-Deoxyguanosine; 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine; 8-Oxo-7,8-Dihydrodeoxyguanosine; 8-Oxo-7-Hydrodeoxyguanosine; 8-Oxo-Deoxyguanosine; 8OHdG

Networked: 1346 relevant articles (24 outcomes, 182 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kawanishi, Shosuke: 24 articles (01/2016 - 06/2003)
2.	Hiraku, Yusuke: 20 articles (01/2016 - 09/2003)
3.	Murata, Mariko: 18 articles (10/2018 - 09/2003)
4.	Ma, Ning: 17 articles (08/2021 - 09/2003)
5.	Olinski, Ryszard: 17 articles (01/2018 - 10/2002)
6.	Oikawa, Shinji: 16 articles (12/2013 - 06/2003)
7.	Gackowski, Daniel: 15 articles (01/2018 - 10/2002)
8.	Poulsen, Henrik Enghusen: 13 articles (10/2021 - 02/2012)
9.	Pinlaor, Somchai: 12 articles (08/2021 - 09/2003)
10.	Rozalski, Rafal: 12 articles (08/2013 - 10/2002)

Related Diseases

1.	Inflammation (Inflammations) 05/01/2002 - "For in vivo studies, we considered the human nose as a target organ, comparing neutrophilic inflammation in the nasal lavage fluid with the oxidative DNA lesion 8-hydroxydeoxyguanosine (8-OHdG) in epithelial cells obtained by nasal brush. " 03/01/2020 - "The influence on inflammation was measured as urinary levels of 8-hydroxy-2'-deoxyguanosine. " 10/01/2019 - "We investigated the association of serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, with mortality in CKD individuals and analyzed whether inflammation modifies the association. " 07/01/2014 - "In contrast, MWCNT-S induced stronger inflammation and higher 8-hydroxydeoxyguanosine level in the lung tissue than MWCNT-L. " 11/01/2006 - "Serum 8-oxo-dG was significantly elevated in persistent inflammation in comparison to noninflamed patients. "
2.	Hypertension (High Blood Pressure) 11/01/2014 - "Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG). " 10/30/2023 - "PubMed, Web of Science) to search for English-language publications up to June 30, 2022 and the terms: DNA damage, comet assay, gammaH2AX, 8OHdG, strand breaks, and arterial hypertension. " 06/01/2007 - "Hypertension significantly increased not only 8-oxo-dG accumulation but also the expression of MTH1 in EC of the aorta during aging. " 06/01/2007 - "Little attention has been given to the biological significance of 8-oxo-dG accumulation in cardiovascular tissues during the different stage of hypertension and its prevention. " 06/01/2007 - "Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension."
3.	Hyperglycemia 01/01/2022 - "Two months after induction of hyperglycemia, systemic oxidative stress was measured using urinary 8-hydroxy-2'-deoxyguanosine. " 08/01/2015 - " of empagliflozin for 4 weeks significantly improved hyperglycemia and HbA1c, and decreased expression levels of AGEs, RAGE, 8-hydroxydeoxyguanosine (8-OHdG), and F4/80, markers of oxidative stress and macrophages, respectively, in the diabetic kidney. " 09/01/2014 - "Although linagliptin treatment for 2 weeks did not improve hyperglycemia in diabetic rats, linagliptin significantly reduced AGEs levels, RAGE gene expression, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress in the kidney of diabetic rats. " 01/10/2014 - "The results demonstrate that 8-Oxo-dG effectively improved hyperglycemia, dyslipidemia and fatty liver changes in obese mice. " 09/01/2006 - "To clarify the mechanism by which hyperglycemia in diabetes mellitus causes endothelial cell damages, the effects of high glucose on DNA fragmentation and caspase-3 activity of cultured endothelial cells and on the generation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) were studied. "
4.	Neoplasms (Cancer) 03/16/2010 - "Earlier studies have reported contradictory data on the function of 8-oxodG as a prognostic factor in different cancer types. " 09/01/2005 - "To clarify the oxidation-related factors, in consideration of cancer risk, this study investigated how urinary 8-OH-dG was associated with occupational and lifestyle factors in 372 healthy workers. " 03/01/2002 - "The present study investigates whether the formation of 8-hydroxydeoxyguanosine (8-OH-dG), a known oxidative DNA damage relevant to carcinogenicity, can be associated with psychological factors, in order to clarify the possible stress-cancer linkage from a genetic viewpoint. " 12/01/2023 - "The accumulation of 8-oxodG has been linked to degenerative diseases and aging, as well as cancer. " 01/26/2023 - "IRS1 was overexpressed in tumor cells and this was associated with a shorter patient survival time and an increase in 8-oxodG. "
5.	Carcinogenesis 03/01/2001 - "The present study was performed to investigate the relationship between work-related factors, including psychological stress, and the formation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OH-dG), in order to examine their possible risk factor for occupational carcinogenesis. " 10/17/2023 - "CCK8 and tumorigenesis assays for proliferation observation, mitochondria ROS (MitoROS) measurement to examine intracellular oxidative stress, and ELISA to analyze concentration of 8-oxo-2'-deoxyguanosine (8-oxo-dG) in cells. " 10/24/2019 - "8-hydroxy-2'-deoxyguanosine (8-OHdG), a product of oxidative damage to 2'-deoxyguanosine, is known as a useful marker for assessing oxidative DNA damage and has been a feature of carcinogenesis in several researches. " 07/01/2018 - "It has been reported that 8-hydroxydeoxyguanosine (8-OHdG), an oxidized DNA lesion, might contribute to chemical carcinogenesis. " 01/01/2018 - "Oxidative stress, as determined by IHC staining of 8-OH-dG, was not altered during prostate tumorigenesis, nor was it affected by administration of δ-T. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Antioxidants
3.	Glucose (Dextrose)
4.	Nitric Oxide (Nitrogen Monoxide)
5.	4-hydroxy-2-nonenal (4-hydroxynonenal)
6.	DNA (Deoxyribonucleic Acid)
7.	Malondialdehyde (Propanedial)
8.	Proteins (Proteins, Gene)
9.	Superoxide Dismutase
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Drug Tapering
4.	Aftercare (After-Treatment)
5.	Intraperitoneal Injections