Maternal Obesity

01/01/2021 - "This study showed that maternal taurine supplementation exerted modest protective effects on cafeteria diet induced maternal obesity. "
01/01/2020 - "The efficacy of taurine supplementation in the setting of maternal obesity on health and well-being of offspring is unknown. "
01/01/2013 - "Further, the efficacy of taurine supplementation in the setting of maternal obesity is not known. "
01/01/2020 - "We examined the effects of taurine supplementation on outcomes related to growth and metabolism in offspring in a rat model of maternal obesity. "
04/01/2015 - "We propose that the reduction in placental TauT activity in maternal obesity could lower syncytiotrophoblast taurine concentration, compromise placental development and function, and reduce the driving force for taurine efflux to the fetus, thereby increasing the risk of poor pregnancy outcome."

09/27/2018 - "Author Correction: Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception."
01/01/2018 - "Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception."
12/23/2020 - "Impact of Maternal Obesity on the Metabolism and Bioavailability of Polyunsaturated Fatty Acids during Pregnancy and Breastfeeding."
06/01/2013 - "Placental fatty acid uptake in both male and female fetuses is sensitive to maternal BMI, but males may have inadequate acquisition of the unsaturated fatty acid OA, when exposed to maternal obesity."

09/09/2019 - "This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and their association with infant growth and cognition to raise awareness about the programming effect of maternal health and to promote a healthy prenatal weight. "
01/01/2021 - "Sex-specific responses in placental fatty acid oxidation, esterification and transfer capacity to maternal obesity."
12/01/2019 - "Maternal obesity was independently associated with higher total SFAs, the "high medium-chain fatty acid" pattern, and lower total MUFAs. "
10/01/2019 - "Placental structure and function can be modified as a result of maternal obesity affecting materno-fetal fatty acids (FA) transport. "
09/09/2019 - "The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition-The PREOBE Follow-Up."

12/01/2014 - "Maternal obesity predicted higher IL-6 at each study visit. "
01/01/2023 - "Obesity in pregnancy is associated with macrophage influx and an upregulated GRO-alpha and IL-6 expression in the decidua."
01/01/2022 - "Treatment with MR16-1 blocks IL-6 signaling in the placenta, but has only limited effects on preventing HFD-associated placental dysfunction and offspring outcomes in mice, suggesting further mechanisms in the deterioration of placental vascularization and fetal nutrient supply as a consequence of maternal obesity."
10/23/2021 - "Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring."
01/22/2020 - "Diet-induced maternal obesity led to an IUGR phenotype accompanied by increased maternal IL-6 serum levels. "

06/07/2018 - "Of note, SIRT7 protein level is significantly decreased in oocytes from obese mice, and the forced expression of exogenous SIRT7 ameliorates maternal obesity-associated meiotic defects and oxidative stress in oocytes. "
01/01/2016 - "In this study, we tested the hypothesis that maternal obesity induced by a high fat diet (HFD) modulates autophagy proteins in the hypothalamus and liver of the offspring of mice. "
09/26/2023 - "The interaction between the identified compounds and maternal obesity genes is established via protein-protein interaction analysis, gene ontology examination, and KEGG pathway analysis. "
02/08/2023 - "Consumption of the HC-PPN diet did not protect against maternal obesity but did improve reproductive success compared with the HC-CP group (72.7% versus 43.7%) and reduced total energy, fat, and protein in maternal milk. "
08/19/2022 - "We aimed to understand the impact of maternal obesity on the metabolism of both pregnant mothers and their offspring, as well as on metabolic, brain, and behavioral development of offspring by utilizing metabolomics, protein, and behavioral assays in a non-human primate model. "

01/01/2022 - "Elevated RIF1 in oocytes caused by maternal obesity may mediate abnormal embryonic epigenetic remodeling and increase metabolic risk in offspring by regulating histone modifications on MuERV-L, which can be partially rescued by metformin treatment."
07/28/2021 - "Gestational metformin attenuated the adiposity in obese dams and increased the gestation length without correcting the offspring in utero growth restriction and catch-up growth caused by maternal obesity. "
07/24/2018 - "There is insufficient evidence to support the use of metformin for women with obesity in pregnancy for improving maternal and infant outcomes. "
01/01/2022 - "Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance."
05/30/2022 - "Because inhibiting these mechanisms in WAT might prevent obesity-related adverse effects, we investigated metformin treatment during pregnancy using a mouse model of diet-induced maternal obesity. "

10/01/2017 - "Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway."
10/01/2017 - "Finally, by performing morpholino knockdown and acetylation-mimetic mutant overexpression assays, we reveal that melatonin ameliorates maternal obesity-induced defective phenotypes in oocytes through the SIRT3-SOD2-dependent mechanism. "
01/01/2018 - "The pro-inflammatory state of obesity in pregnancy may drive activation of IDO-1, resulting in diversion of TRP away from serotonin and melatonin production and toward KYN metabolites. "
01/01/2018 - "Maternal obesity is associated with increased oxidative stress but decreased placental mitochondrial respiration and expression of mitochondrial electron transport chain (ETC) complexes I to V. Melatonin acts as an antioxidant and prevents oxidative stress-induced changes in cytotrophoblasts. "
01/31/2023 - "This study examined the effects of maternal obesity on human colostrum lymphocytes and the intracellular mechanisms of lymphocyte modulation in the presence of leptin, adiponectin, and melatonin via cell proliferation; the release of intracellular calcium; and apoptosis induction. "

08/11/2022 - "Additional in vivo studies are required to identify the efficacy of selenium supplementation in preventing inflammatory pathways activated by GDM and maternal obesity and to elucidate the mechanism involved."
08/11/2022 - "Therefore, this study aimed to investigate the effect of selenium supplementation on an in vitro model of GDM and maternal obesity. "
08/11/2022 - "These findings indicate that selenium may be able to prevent inflammation and oxidative stress associated with GDM and maternal obesity. "
08/11/2022 - "Evidence suggests selenium supplementation may be linked to disease prevention in pregnancy; however, the specific effects of selenium on inflammation and oxidative stress associated with GDM and maternal obesity are unknown. "

01/01/2017 - "Maternal obesity increased Kiss1 mRNA expression in the MePD of pre-pubertal male and female offspring, whereas Kiss1 expression was not affected in the ARC or AVPV at this age. "
09/01/2014 - "Obesity in pregnancy is associated with negative regulation of adpN adipose expression with increase in adpN DNA methylation associated with lower mRNA concentrations and hypoadiponectinemia. "
10/01/2013 - "In the hippocampus, maternal obesity was associated with up-regulated fat mass and obesity-associated gene and TNF-α mRNA. "
01/01/2022 - "Sex-differential RXRα gene methylation effects on mRNA and protein expression in umbilical cord of the offspring rat exposed to maternal obesity."
01/01/2020 - "Likewise, MMP15 mRNA and protein levels were unaltered between human first trimester placentas from control pregnancies vs those complicated with maternal obesity. "

03/01/2011 - "Maternal obesity was associated with significantly greater IL-1β (p < 0.05), IL-8 (p < 0.05), MCP-1 (p < 0.001) and CXCR2 (p < 0.05) mRNA expression within the placenta and higher circulating maternal levels of IL-6 (3.30 ± 0.38 vs. 1.77 ± 0.15 pg/ml) (p < 0.001) compared with non-obese women. "
08/19/2017 - "Maternal obesity is a major risk factor for pregnancy complications, causing inflammatory cytokine release in the placenta, including interleukin-1β (IL-1β), IL-6, and IL-8. "
08/01/2008 - "Our results suggest an impaired balance between circulating pro- and anti-inflammatory cytokines in patients with gestational diabetes; however, a significant contribution of maternal obesity to the increased levels of IL-8 and IL-18 should be underlined."
07/01/2011 - "Maternal obesity enhanced mRNA expression tumor necrosis factor (TNF)α, interleukin (IL)1α, IL1β, IL6, IL8, and monocyte/macrophage chemotactic protein-1 (MCP1), as well as macrophage markers, CD11b, CD14, and CD68 in fetal gut. "

01/01/2016 - "The purpose of the present study is to evaluate whether the presence of maternal obesity reduces the efficacy of cervical cerclage. "
05/01/2023 - "This study aimed to evaluate the impact of maternal obesity on the risk for spontaneous preterm delivery and the risk for overall preterm delivery among patients with cervical cerclage placement. "
05/01/2023 - "Impact of maternal obesity on preterm delivery in patients with cervical cerclage."

01/01/2022 - "The gold-standard intrauterine pressure catheter (IUPC) is invasive and requires ruptured membranes, while the standard-of-care, external tocodynamometry (TOCO)'s accuracy is hampered by obesity, maternal movements, and belt positioning. "
05/01/2018 - "The aims of this study were to determine the diagnostic value of EHG in comparison to (1) the intrauterine pressure catheter (IUPC), (2) the external tocodynamometer (TOCO), and (3) in case of maternal obesity; (4) to evaluate EHG from users' and patients' perspectives; and (5) to assess whether EHG can predict labor outcome. "

01/01/2019 - "Some of these risk factors, such as maternal obesity, may be amendable with improved antenatal care. "
01/01/2022 - "The development of individualised and flexible plans for avoiding adverse outcomes of obesity in pregnancy will require investment in training of health professionals and better integration into normal antenatal care."
02/01/2020 - "The most common risk factors in this population were maternal obesity (37.6%), late prenatal care (35.0%), and maternal smoking (22.4%). "
11/01/2019 - "Guideline No. 391-Pregnancy and Maternal Obesity Part 1: Pre-conception and Prenatal Care."
01/01/2016 - "Maternal obesity is associated with increased adequacy of prenatal care. "

12/01/2010 - "Prepregnancy care had benefits beyond improved glycemic control and was a stronger predictor of pregnancy outcome than maternal obesity, ethnicity, or social disadvantage."
06/01/1990 - "Maternal obesity or failure to achieve glycemic control should alert the clinician to a substantially increased risk of macrosomia."
02/01/2014 - "Glycemic control is the most important modifiable risk factor for congenital anomaly in women with type 2 diabetes, whereas maternal obesity and social disadvantage are associated with large for gestational age neonates. "
01/01/2012 - "The meeting, which was co-hosted by the Washington Hospital Center and the University of Maryland School of Medicine focused on five broad themes: (i) the prevention of diabetes and its risk factors, such as obesity, in pregnancy; (ii) the appropriate use of pharmacotherapies for managing diabetes in pregnancy; (iii) optimal glycemic control; (iv) the value of nutrition, exercise and limiting weight gain during pregnancy and (v) the diagnosis and consequences of diabetic fetopathy. "
02/01/2015 - "Although macrosomic stillborns were more common in diabetic women with %hemoglobin A1c >6 and body mass index >30 kg/m, fetal steatosis was independent of glycemic control, maternal obesity, type of diabetes, ethnicity, or fetal sex in our cohort. "

11/01/2020 - "The results of studies on the demographic reasons of maternal request for elective cesarean section were advanced maternal age, parity, occupation, education, maternal obesity, family status, decreasing level of religiosity, household income, number of living children and age at marriage.Conclusions"
01/01/2023 - "Maternal obesity is associated with increased risk of prolonged and dysfunctional labor and emergency caesarean section. "
11/30/2021 - "There were significant association between maternal obesity with hypertensive disorder in pregnancy (p=0.025), caesarean section delivery (p=0.002) and macrosomic infant (p <0.001). "
09/01/2021 - "At the time of term cesarean section, preexisting maternal obesity and GDM are associated with lower Metrnl levels in cord plasma. "
11/26/2020 - "Use of the Robson classification to understand the increased risk of cesarean section in case of maternal obesity."