Obesity in pregnancy is associated with macrophage influx and an upregulated GRO-alpha and IL-6 expression in the decidua.

Abstract

About one third of all reproductive-aged women are affected by obesity. Maternal obesity is linked to an adverse outcome for both mother and child. The expression of the pro-inflammatory IL-6 and GRO-alpha as well as the infiltration of macrophages in the placenta of obese, non-diabetic pregnancies was examined by immunohistochemistry in comparison to the placenta of normal weight women. In obese pregnancies the influx of macrophages was significantly increased (p = 0.012). The protein expression of IL-6 and GRO-alpha was significantly elevated (p = 0.036 and p < 0.001, respectively) in the decidua of adipose females.

• Authors: Sanja Löb, Julia Knabl, Aurelia Vattai, Elisa Schmoeckel, Christina Kuhn, Johanna Mittelberger, Achim Wöckel, Sven Mahner, Udo Jeschke
• Journal: Journal of reproductive immunology (J Reprod Immunol) Vol. 156 Pg. 103800 (03 2023) ISSN: 1872-7603 [Electronic] Ireland
• PMID: 36640674 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Elsevier B.V. All rights reserved.

Chemical References

• Interleukin-6
• CXCL1 protein, human
• IL6 protein, human

Topics

• Adult
• Child
• Female
• Humans
• Pregnancy
• Decidua (metabolism)
• Interleukin-6 (metabolism)
• Macrophages (metabolism)
• Obesity (metabolism)
• Obesity, Maternal (metabolism)