Midkine

A developmentally regulated, HEPARIN-binding secreted growth factor homologous to pleiotrophin (PTN). It regulates cell proliferation through its interaction with ANAPLASTIC LYMPHOMA KINASE (ALK) and is involved in the formation of NEOINTIMA following arterial injury.

Also Known As:

Networked: 569 relevant articles (20 outcomes, 82 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kadomatsu, Kenji: 50 articles (08/2021 - 01/2002)
2.	Muramatsu, Takashi: 41 articles (02/2014 - 01/2002)
3.	Tagawa, Masatoshi: 18 articles (09/2017 - 01/2002)
4.	Ikematsu, Shinya: 15 articles (08/2021 - 01/2003)
5.	Muramatsu, T: 15 articles (03/2005 - 01/2000)
6.	Muramatsu, Hisako: 14 articles (11/2015 - 01/2002)
7.	Kadomatsu, K: 14 articles (02/2014 - 01/2000)
8.	Shimada, Hideaki: 13 articles (03/2019 - 01/2003)
9.	Sato, Waichi: 13 articles (08/2017 - 01/2002)
10.	Yao, Xing: 12 articles (11/2019 - 10/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "This study aimed to investigate a larger collective to ascertain if the preoperative serum midkine level (S-MK) is suitable as a marker for screening and if S-MK correlates with tumor progression and localization. " 01/01/2015 - "Recent studies have shown that Midkine is up-regulated in several types of human cancers. " 09/01/2010 - "The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. " 11/01/1996 - "Recent studies have implicated a role for midkine (MK) in cancer progression. " 05/14/2023 - "Role of Midkine in Cancer Drug Resistance: Regulators of Its Expression and Its Molecular Targeting."
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2022 - "Specifically, a previous study showed that IGF-1R inhibition downregulated Midkine expression in hepatocellular carcinoma (HCC). " 01/01/2020 - "Midkine (MDK) has been proposed as one of the most promising markers for hepatocellular carcinoma (HCC). " 01/01/2020 - "Comparison of diagnostic accuracy of Midkine and AFP for detecting hepatocellular carcinoma: a systematic review and meta-analysis." 01/01/2020 - "There have been many reports on midkine as a promising marker in the diagnosis of hepatocellular carcinoma (HCC). " 01/01/2020 - "Diagnostic accuracy of midkine for hepatocellular carcinoma: A meta-analysis."
3.	Neuroblastoma 02/15/2013 - "In this study, we used a MYCN transgenic model for neuroblastoma in which midkine is highly expressed in precancerous lesions of sympathetic ganglia. " 10/01/2008 - "The present study evaluated the plasma midkine level in human neuroblastoma patients. " 02/01/2014 - "In contrast to these tumours, midkine was found to be expressed in every neuroblastoma cell line tested and the knockdown of midkine alone was sufficient to suppress their growth. " 02/01/2014 - "Involvement of midkine in neuroblastoma tumourigenesis." 02/15/2013 - "Midkine promotes neuroblastoma through Notch2 signaling."
4.	Hyperplasia 08/01/2008 - "The mechanism of inhibition of intimal hyperplasia might be associated with midkine suppression." 06/01/2008 - "Knockdown of midkine expression suppresses neointimal hyperplasia. " 08/01/2008 - "In this study, the efficacy of pitavastatin was evaluated on intimal hyperplasia and midkine expression of experimental normocholesterolemic rabbit autologous vein graft. " 06/01/2008 - "Neointimal hyperplasia is strikingly suppressed in an endothelium injury model in mice deficient in the growth factor midkine. " 09/01/2006 - "Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts."
5.	Malignant Mesothelioma 11/01/2013 - "Our data demonstrate that Ad35 fiber modification of binding tropism in a midkine promoter-regulated oncolytic Ad5 vector confers transductional targeting to oncolytic adenoviruses, thereby facilitating more effective treatment of malignant mesothelioma. " 11/01/2013 - "Enhanced antitumor efficacy of fiber-modified, midkine promoter-regulated oncolytic adenovirus in human malignant mesothelioma." 08/01/2010 - "Complete regression of human malignant mesothelioma xenografts following local injection of midkine promoter-driven oncolytic adenovirus." 08/01/2010 - "We hypothesized that the tumor-specific midkine (Mdk) promoter could confer transcriptional targeting to oncolytic adenoviruses for effective treatment of malignant mesothelioma. " 01/01/2017 - "Midkine is a potential novel marker for malignant mesothelioma with different prognostic and diagnostic values from mesothelin."

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Tretinoin (Retinoic Acid)
4.	Osteopontin
5.	pitavastatin (itavastatin)
6.	Antisense Oligonucleotides
7.	Nerve Growth Factors (Neurotrophins)
8.	Cisplatin (Platino)
9.	Doxorubicin (Adriamycin)
10.	Nucleotide Aptamers

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Nephrectomy
4.	Ligation
5.	Renal Dialysis (Hemodialysis)