Terlipressin

An inactive peptide prodrug that is slowly converted in the body to lypressin. It is used to control bleeding of ESOPHAGEAL VARICES and for the treatment of HEPATORENAL SYNDROME.

Also Known As:

Glipressin; Gly-Gly-Gly-8-Lys-vasopressin; Glycylpressin; Glypressin; N-(alpha)-glycyl-glycyl-glycyl-8-lysine vasopressin; Remestyp; TGLVP; Terlypressin; Triglycyl Lysine Vasopressin; Triglycyl-(8-lysine)vasopressin; Triglycylvasopressin; Vasopressin, tri-Gly-8-Lys-; Gly Gly Gly 8 Lys vasopressin; tri-Gly-8-Lys- Vasopressin; N-(N- (N-glycylglycyl)glycyl)-L-lysinevasopressin

Networked: 750 relevant articles (129 outcomes, 184 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Morelli, Andrea: 16 articles (01/2018 - 04/2004)
2.	Westphal, Martin: 16 articles (06/2011 - 02/2003)
3.	Ertmer, Christian: 14 articles (01/2018 - 08/2006)
4.	Krag, Aleksander: 12 articles (01/2020 - 12/2007)
5.	Qi, Xingshun: 11 articles (01/2022 - 12/2017)
6.	Ginès, Pere: 11 articles (01/2017 - 10/2002)
7.	Bendtsen, Flemming: 10 articles (01/2020 - 05/2005)
8.	Møller, Søren: 9 articles (01/2020 - 05/2005)
9.	López-Herce, Jesús: 9 articles (02/2016 - 01/2006)
10.	Tsianos, Epameinondas V: 9 articles (08/2012 - 07/2005)

Related Diseases

1.	Hepatorenal Syndrome 05/01/2011 - "Finally, we understand its use associated to terlipressin seems to be the best treatment strategy for type I hepatorenal syndrome. " 10/01/2008 - "Studies suggest that terlipressin is effective in the treatment of hepatorenal syndrome (HRS). " 11/01/2009 - "Terlipressin has been shown to be effective in the management of hepatorenal syndrome. " 02/27/2004 - "Terlipressin and Gelatinepolysuccinat appear to be a safe and effective treatment of hepatorenal syndrome." 01/01/2023 - "Early treatment with terlipressin in patients with hepatorenal syndrome yields improved clinical outcomes in North American studies."
2.	Hemorrhage 11/01/2018 - "Compared with no vasoactive drug, terlipressin significantly improved the control of bleeding within 48 hours (OR = 2.94, P = .0008) and decreased the in-hospital mortality (OR = 0.31, P = .008). " 04/01/2010 - "In patients with variceal bleeding, the bleeding control is significantly improved by early administration of terlipressin. " 09/01/1991 - "High-dose terlipressin (84%) seemed to be more effective in the initial control of bleeding than low-dose terlipressin (67%); however this difference was not significant. " 12/01/2019 - "Terlipressin has been shown to be effective in controlling variceal bleeding and decreasing associated mortality. " 05/01/2005 - "Portal hypotensive effect of terlipressin is less effective when given during hemorrhage than in stable state. "
3.	Fibrosis (Cirrhosis) 01/01/2022 - "Safety and efficacy of outpatient continuous terlipressin infusion for the treatment of portal hypertensive complications in cirrhosis." 08/01/2002 - "In patients with type 1 HRS treated with terlipressin, patients with improved renal function had less severe cirrhosis (Child-Pugh >10 but < or =13) than patients without. " 11/08/2023 - "In a multi-center inpatient cirrhosis study of patients not exposed to terlipressin, 15% patients developed RF. " 10/01/2018 - "The objective of this study was to examine whether terlipressin treatment of patients without cirrhosis leads to more serious fluctuations in PNa than in cirrhosis. " 11/01/2009 - "The aim of the present study was to assess the effects of terlipressin on systemic, hepatic and renal hemodynamics in cirrhosis. "
4.	Hypotension (Low Blood Pressure) 11/01/2011 - "Although the number of reported infants is little, terlipressin appears to be an effective rescue treatment in different scenarios of refractory neonatal hypotension. " 04/01/2008 - "Terlipressin promptly reversed hypotension and improved tissue perfusion without adverse effects. " 10/22/2022 - "MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, and Google Scholar from inception to September 2021 were searched for studies of AVP and terlipressin in the treatment of hypotension of any cause in preterm neonates. " 10/01/2023 - "The treatment of hypotension in HS with saline and/or terlipressin cannot restore cerebral perfusion or oxygenation in experimental models of HS and severe TBI. " 10/22/2022 - "AVP and terlipressin may improve measured blood pressure values and possibly end-organ perfusion among neonates with refractory hypotension. "
5.	Septic Shock (Toxic Shock Syndrome) 06/01/2011 - "In fluid-resuscitated patients with septic shock (with a MAP between 65 and 75 mmHg), a bolus infusion of 0.5 mg terlipressin was effective in reducing NE requirements without worsening microcirculatory blood flow. " 10/01/2006 - "Our data suggest that terlipressin is effective in septic shock. " 01/01/2019 - "Terlipressin for septic shock patients: a meta-analysis of randomized controlled study." 11/01/2018 - "In this multicentre, randomised, double-blinded trial, we observed no difference in mortality between terlipressin and NE infusion in patients with septic shock. " 11/01/2018 - "In this multicentre, randomised, double-blinded trial, patients with septic shock recruited from 21 intensive care units in 11 provinces of China were randomised (1:1) to receive either terlipressin (20-160 µg/h with maximum infusion rate of 4 mg/day) or NE (4-30 µg/min) before open-label vasopressors. "

Related Drugs and Biologics

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5.	Somatostatin (Somatotropin Release-Inhibiting Factor)
6.	Vasoconstrictor Agents
7.	Midodrine (Midon)
8.	Nitroglycerin (Dynamite)
9.	Catecholamines
10.	Sodium

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Sclerotherapy
4.	Surgical Portasystemic Shunt (Portosystemic Shunt)
5.	Transjugular Intrahepatic Portasystemic Shunt