Valacyclovir (Valtrex)

A prodrug of acyclovir that is used in the treatment of HERPES ZOSTER and HERPES SIMPLEX VIRUS INFECTION of the skin and mucous membranes, including GENITAL HERPES.

Also Known As:

Valtrex; 256U87; 2-((2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl L-valinate; Acyclovir, L-valyl Ester; BW256U87; L-Valylacyclovir; Valaciclovir; Valacyclovir Hydrochloride; Valacyclovir Hydrochloride, (DL)-isomer; Valacyclovir, (D)-isomer; Valacyclovir, (DL)-isomer; Valacyclovir, (L)-isomer; Valacyclovir, D-; Valacyclovir, X-Hydrochloride, (D)-isomer; Valacyclovir, X-Hydrochloride, (DL)-isomer; Acyclovir, L valyl Ester; D- Valacyclovir; L Valylacyclovir; L-valyl Ester Acyclovir

Networked: 799 relevant articles (146 outcomes, 159 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        Acyclovir: 4814
        Valacyclovir: 799
        val-valacyclovir: 2

Experts

1.	Wald, Anna: 12 articles (12/2016 - 10/2003)
2.	Tyring, Stephen K: 10 articles (01/2017 - 10/2002)
3.	Tyring, Stephen: 10 articles (12/2016 - 09/2006)
4.	Warren, Terri: 8 articles (12/2016 - 10/2003)
5.	Corey, Lawrence: 6 articles (12/2016 - 01/2004)
6.	Cohen, Elisabeth J: 5 articles (05/2022 - 10/2015)
7.	Bouda, Mirko: 5 articles (01/2019 - 12/2002)
8.	Suzuki, Hiroshi: 5 articles (12/2018 - 08/2010)
9.	Fife, Kenneth H: 5 articles (01/2009 - 10/2006)
10.	Jeng, Bennie H: 4 articles (05/2022 - 01/2019)

Related Diseases

1.	Infections 04/01/1997 - "This study has demonstrated that once daily valaciclovir (500 mg), is highly effective and well tolerated for the suppression of recurrent genital HSV infection. " 01/01/2021 - "A recent randomized trial found that high-dose valaciclovir treatment resulted in a significant reduction in fetal infection after first-trimester maternal primary infection, leading to calls to start routine serologic screening in pregnancy. " 01/01/2009 - "Our study is the first to demonstrate a significant reduction in viral shedding with valacyclovir 1 g daily compared to placebo in a population of subjects newly diagnosed with HSV-2 infection." 01/01/2022 - "High-dose valacyclovir appears to be safe and effective for the prevention of cCMV among women with first-trimester primary CMV infection. " 03/31/2020 - "Valacyclovir prophylaxis for 3 months showed significant reduction in the incidence of CMV infection in KTRs. "
2.	Herpes Zoster 01/01/2014 - "[Ophthalmic zoster of th eyelid: good outcome with valaciclovir]." 09/01/2000 - "Current wholesale prices indicate that valacyclovir is the more cost-effective treatment for herpes zoster ($83.90 vs $140.70 per course)." 11/01/1996 - "Valaciclovir is an effective treatment for herpes zoster in immunocompetent adults. " 05/01/2007 - "Oral valacyclovir 1.5 g bid is safe and effective for the treatment of uncomplicated herpes zoster in immunocompetent patients over 18 years of age. " 05/01/2008 - "The objective of this study was to assess the safety and efficacy of an oral dosage of valacyclovir, 1 g TID versus 2 g TID, for the treatment of herpes zoster in immunocompromised patients > or =18 years of age. "
3.	Herpes Genitalis (Genital Herpes) 09/01/1998 - "Thus, valaciclovir is highly effective and well tolerated for suppression of recurrent genital herpes. " 11/01/2004 - "Valacyclovir at 500 mg twice daily was effective in preventing or delaying recurrences of genital herpes compared with placebo (hazard ratio, 0.20; 95% CI, 0.13-0.30; P<.001) and with valacyclovir at 1000 mg once daily (hazard ratio, 0.56; 95% CI, 0.40-0.80; P=.001), in 6-month and 48-week studies, respectively. " 07/01/2008 - "Valacyclovir 1 g once daily administered for 24 weeks was well-tolerated and effective in suppressing genital herpes recurrences in immunocompetent newly diagnosed persons without an established recurrence pattern." 03/01/2003 - "Valacyclovir is effective for suppressive and episodic treatment of recurrent genital herpes. " 10/01/1999 - "A double-blind, randomized, controlled, multicriteria equivalence trial was conducted to determine whether od treatment with valacyclovir 1000 mg is as effective as bd treatment with 500 mg in patients with recurrent genital herpes. "
4.	Pain (Aches) 06/01/2021 - "The present study indicates that early treatment with high-dose valaciclovir can significantly reduce pain in patients, especially in elderly patients, in whom it can also reduce the incidence of PHN. " 11/01/2021 - "At the baseline examination, all 10 valacyclovir and 9 placebo patients exhibited moderate to severe pain and 18 patients needed pain medication. " 08/01/2012 - "No EPB-348 group was non-inferior to valacyclovir for time to cessation of new lesion formation or time to cessation of pain by Day 120, though no significant differences occurred between treatment groups. " 09/01/2004 - "The mean time to pain cessation was significantly less in the valacyclovir group (3.2 days) than in the placebo group (6.2 days) (P = .006). " 04/01/2004 - "The effect of valacyclovir on pain and tenderness and FIQ did not differ from placebo. "
5.	Herpes Labialis (Fever Blister) 03/01/2003 - "Two identical, randomized, double-blind, parallel-group studies were conducted to evaluate the efficacy of oral valacyclovir 500 mg (n=49) versus placebo (n=49) once daily for 16 weeks in the suppression of herpes labialis among patients with a history of 4 or more recurrent lesions in the previous year. " 03/01/2003 - "These studies provide evidence supporting a simple, 1-day valacyclovir treatment regimen for cold sores that is safe and effective. " 03/01/2003 - "The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported. " 09/01/2004 - "The authors enrolled 125 otherwise healthy HSV-seropositive adults who reported having recurrent herpes labialis (more than one episode per year and at least one episode in the previous year) in a randomized, double-blind, placebo-controlled study and gave them valacyclovir prophylactically (2 grams taken twice on the day of dental treatment and 1 g taken twice the next day) or a matching placebo. " 09/01/2004 - "This study determined the efficacy and safety of oral valacyclovir in suppressing dentally related cold sore outbreak and HSV shedding. "

Related Drugs and Biologics

1.	Acyclovir (Aciclovir)
2.	Famciclovir (Famvir)
3.	Antiviral Agents (Antivirals)
4.	Prodrugs
5.	Ganciclovir (Cytovene)
6.	Valacyclovir (Valtrex)
7.	penciclovir (Denavir)
8.	Steroids
9.	Prednisone (Sone)
10.	Cidofovir (Vistide)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Kidney Transplantation
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Stem Cell Transplantation