Tamsulosin (Flomax)

A sulfonamide derivative and adrenergic alpha-1 receptor antagonist that is used to relieve symptoms of urinary obstruction caused by BENIGN PROSTATIC HYPERPLASIA.

Also Known As:

Flomax; 5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide; LY 253352; LY-253352; Tamsulosin Hydrochloride; YM 617; YM-617; 5-((2R)-2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxy-benzenesulfonamide

Networked: 1087 relevant articles (218 outcomes, 328 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133

Experts

1.	Kaplan, Steven A: 35 articles (12/2021 - 11/2006)
2.	Roehrborn, Claus G: 22 articles (07/2021 - 11/2006)
3.	Oelke, Matthias: 11 articles (07/2021 - 05/2012)
4.	Montorsi, Francesco: 11 articles (12/2016 - 02/2008)
5.	Michel, Martin C: 10 articles (07/2021 - 01/2004)
6.	Wilson, Timothy H: 10 articles (05/2020 - 02/2011)
7.	Barkin, Jack: 9 articles (04/2014 - 11/2007)
8.	Gacci, Mauro: 8 articles (12/2021 - 06/2012)
9.	Ye, Zhangqun: 8 articles (01/2021 - 07/2011)
10.	Bae, Jae Hyun: 8 articles (09/2020 - 05/2012)

Related Diseases

1.	Lower Urinary Tract Symptoms 04/01/2009 - "In conclusion, it was clear that Tamsulosin caused significant improvement in lower urinary tract symptoms associated with BPH as a whole from a very early stage within one week after administration." 06/01/2000 - "Tamsulosin markedly improved lower urinary tract symptoms. " 02/01/2009 - "Tamsulosin demonstrated no clinically significant effect on blood pressure, while proving to be a safe and effective treatment option for lower urinary tract symptoms in a select pediatric population." 08/01/2014 - "Previous studies have revealed that tamsulosin is effective in improving lower urinary tract symptoms (LUTS) and erectile functioning but has some inhibitory effects on ejaculation, including decreased ejaculatory volume. " 01/01/2002 - "Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms."
2.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/01/2013 - "Tamsulosin hydrochloride is one of the most potent drugs for treatment of benign prostatic hyperplasia (BPH), however, the efficacy of tamsulosin hydrochloride varies among individuals. " 06/24/2009 - "Tamsulosin (0.3-300 microg/kg) also dose-dependently inhibited the intraurethral pressure increase in both groups, but it had a hypotensive effect that was significantly greater in old than in young dogs with benign prostatic hyperplasia. " 11/01/1998 - "Tamsulosin was safe and effective, and clinically and statistically superior to placebo in relieving symptoms of benign prostatic hyperplasia in men with moderate to severe symptoms at baseline. " 09/01/2017 - "The Authors Reply: Reply on "Evidence Is Enough?: A Systematic Review and Network Meta-Analysis of the Efficacy of Tamsulosin 0.2 mg and Tamsulosin 0.4 mg as an Initial Therapeutic Dose in Asian Benign Prostatic Hyperplasia Patients"." 09/01/2017 - "Letter to the Editor: Commentary on "Evidence Is Enough?: A Systematic Review and Network Meta-Analysis of the Efficacy of Tamsulosin 0.2 mg and Tamsulosin 0.4 mg as an Initial Therapeutic Dose in Asian Benign Prostatic Hyperplasia Patients"."
3.	Overactive Urinary Bladder (Overactive Bladder) 01/01/2017 - "Tamsulosin, an α1-adrenoceptor blocker, is also considered the most effective regimen for patients with LUT symptoms such as BPH and overactive bladder (OAB). " 07/01/2017 - "In addition, tamsulosin improved the Overactive Bladder Questionnaire score when compared with placebo in only one RCT. " 01/01/2016 - "After taking tamsulosin, on the V2 and V3, both groups had improved overactive bladder syndrome symptom scores, patient perception of bladder condition, IPSS, QoL, and GDS. " 01/01/2021 - "This was a planned, exploratory analysis of a 4-week, α-blocker (tamsulosin 0.4 mg) run-in phase of the Male Overactive Bladder Trial in Veterans (MOTIVE). " 01/01/2021 - "MATCH was a randomized, double-blind, placebo-controlled study enrolling Japanese and Korean men aged ≥ 40 years who still had overactive bladder (OAB) symptoms while receiving tamsulosin. "
4.	Urinary Retention 01/01/2016 - "The most frequent complication was acute urinary retention at a rate of 12.5%, however, the use of a single prophylactic dose of tamsulosin was found to be beneficial, with 13 cases needed to treat to prevent one episode. " 02/01/2019 - "It seems that the use of prophylactic tamsulosin is more effective in decreasing the incidence of acute urinary retention, decreasing the PVR in the bladder, and decreasing the diameter of the urine flow in patients after colporrhaphy." 11/01/2020 - "Prophylactic tamsulosin use may be effective in preventing postoperative urinary retention in female patients undergoing pelvic reconstructive surgery." 01/01/2023 - "To determine if administration of tamsulosin before and/or after surgery is safe and effective in preventing postoperative urinary retention (POUR). " 03/01/2023 - "The meta-analysis aimed to integrate the evidence of randomized control trials to estimate the efficacy of prophylactic tamsulosin on postoperative urinary retention (POUR). "
5.	Shock 11/01/2005 - "To evaluate whether tamsulosin, as an alpha(1)-blocker, was effective for the treatment of steinstrasse in the lower ureter after shock wave lithotripsy. " 08/01/2013 - "The objective of this study was to evaluate the efficacy of tamsulosin on stone clearance after extracorporeal shock wave lithotripsy (ESWL) in patients with a single proximal ureteral stone. " 03/01/2008 - "Several randomized trials published recently have demonstrated the role of tamsulosin in helping the clearance of ureteric fragments after shock wave lithotripsy. " 01/01/2022 - "Efficacy of Adjuvant Tamsulosin for Improving the Stone-Free Rate after Extracorporeal Shock Wave Lithotripsy in Renal Stones: A Randomized Controlled Trial." 11/01/2016 - "This review focuses on the efficacy of tamsulosin based on stone location, after shock wave lithotripsy, compared with other MET drugs and in the acute setting of the ED."

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Related Therapies and Procedures

1.	Therapeutics
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3.	Catheters
4.	Stents
5.	Brachytherapy