Effect of tamsulosin on systemic blood pressure and nonneurogenic dysfunctional voiding in children.

Abstract

PURPOSE:

A number of therapies for dysfunctional voiding in children have been proposed after conservative measures have failed. Prior studies have shown significant improvement in lower urinary tract symptoms with alpha1-adrenergic antagonists. Nonselective alpha1-adrenergic antagonists can result in systemic vasodilatation and hypotension. We examined the effects of tamsulosin, a uroselective alpha1A-adrenergic antagonist, on blood pressure, as well as its safety and efficacy in the treatment of dysfunctional voiding in a pediatric population.

MATERIALS AND METHODS:

A total of 23 children without anatomical or neurogenic abnormalities presented with lower urinary tract symptoms refractory to conservative measures. All children had increased post-void residual urine or abnormal uroflowmetry in the absence of pelvic floor activity suggestive of bladder neck dysfunction. All patients were administered tamsulosin daily. Voiding diaries, blood pressure, uroflowmetry studies and patterns along with assessment of post-void residual urine were obtained before and after beginning tamsulosin in all children.

RESULTS:

Median duration of tamsulosin therapy was 7 months, and patient followup was 20 months. The number of voiding and incontinent episodes significantly decreased during treatment compared to baseline (p <0.05). Mean blood pressures before and during tamsulosin treatment were 98/55 mm Hg and 110/61 mm Hg, respectively. Significant increases in average and maximum urinary flow rates along with reduction in post-void residual urine were observed during tamsulosin therapy compared to baseline values (p <0.01). A 50% reduction in the number of abnormal uroflow patterns was observed with tamsulosin therapy.

CONCLUSIONS:

Tamsulosin demonstrated no clinically significant effect on blood pressure, while proving to be a safe and effective treatment option for lower urinary tract symptoms in a select pediatric population.

• Authors: Brian A Vanderbrink, Jordan Gitlin, Sylvia Toro, Lane S Palmer
• Journal: The Journal of urology (J Urol) Vol. 181 Issue 2 Pg. 817-22; discussion 822 (Feb 2009) ISSN: 1527-3792 [Electronic] United States
• PMID: 19110267 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Sulfonamides
• Tamsulosin

Topics

• Adolescent
• Adrenergic alpha-Antagonists (therapeutic use)
• Blood Pressure (drug effects)
• Blood Pressure Determination
• Child
• Child, Preschool
• Cohort Studies
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Follow-Up Studies
• Humans
• Male
• Probability
• Retrospective Studies
• Risk Assessment
• Severity of Illness Index
• Sulfonamides (therapeutic use)
• Tamsulosin
• Treatment Outcome
• Urinary Retention (complications, diagnosis, drug therapy)
• Urinary Tract Infections (etiology, prevention & control)
• Urination Disorders (complications, diagnosis, drug therapy)
• Urodynamics