Pregnane X Receptor

Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.

Also Known As:

Networked: 398 relevant articles (11 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mani, Sridhar: 19 articles (02/2022 - 09/2005)
2.	Gonzalez, Frank J: 11 articles (11/2021 - 04/2007)
3.	Huang, Min: 9 articles (01/2022 - 08/2015)
4.	Li, Hao: 8 articles (02/2022 - 08/2011)
5.	Gao, Yue: 8 articles (01/2022 - 09/2014)
6.	Zhou, Changcheng: 8 articles (01/2022 - 06/2006)
7.	Chen, Taosheng: 8 articles (01/2020 - 11/2008)
8.	Dou, Wei: 7 articles (01/2021 - 01/2012)
9.	Venkatesh, Madhukumar: 7 articles (01/2017 - 09/2008)
10.	Evrard, Alexandre: 6 articles (07/2021 - 03/2010)

Related Diseases

1.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/01/2011 - "However, there are controversial studies on the role of PXR/NR1I2 in inflammatory bowel disease (IBD). " 07/01/2009 - "Studies in adults characterized the role of the pregnane X receptor (PXR) in the pathophysiology of inflammatory bowel disease (IBD) with conflicting results; pediatric studies are still lacking. " 11/01/2021 - "St. John's wort (SJW), from traditional herbs, activates the pregnane X receptor (PXR), a potential drug target for treating inflammatory bowel disease (IBD). " 02/10/2020 - "The pregnane-X-receptor (PXR) is involved in inflammatory bowel disease (IBD). " 11/12/2019 - "In vitro, ALA inhibited NF-κB nuclear translocation and dose-dependently activated human/mouse pregnane X receptor (PXR), a key regulator gene in inflammatory bowel disease (IBD) pathogenesis. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2021 - "Phthalates promote the invasion of hepatocellular carcinoma cells by enhancing the interaction between Pregnane X receptor and E26 transformation specific sequence 1." 01/01/2020 - "The pregnane X receptor (PXR) not only plays an important role in cellular metabolism processes but also induces the resistance of hepatocellular carcinoma (HCC) cells to molecularly targeted drugs by mediating their metabolism and clearance by these cells. " 10/01/2012 - "In vitro, RMP inhibited ATX expression in human HepG2 hepatoma cells and hepatoma cells overexpressing the pregnane X receptor (PXR), but not in hepatoma cells in which PXR was knocked down. " 12/01/2013 - "In clinic samples, the expression of pregnane X receptor was high in hepatitis B virus-associated liver cirrhosis and stage I hepatocellular carcinoma, but low in state II and stage III hepatocellular carcinoma. " 01/01/2020 - "miR-3609 Decelerates the Clearance of Sorafenib in Hepatocellular Carcinoma Cells by Targeting EPAS-1 and Reducing the Activation of the Pregnane X Receptor Pathway."
3.	Inflammation (Inflammations) 04/03/2021 - "A genetic prognostic score was generated integrating IL15RA-rs7910212 and SMAD3-rs7179840 markers with inflammation-related prognostic polymorphisms we previously identified in the same study population (i.e., PXR [NR1I2]-rs1054190, VDR-rs7299460). " 11/18/2021 - "IPA also effectively protected against LPS-induced C2C12 cells inflammation by activating Pregnane X Receptor and restoring the inhibited miR-26a-2-3p expression. " 01/01/2020 - "The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. " 11/01/2017 - "Correction to "Involvement of Nuclear Factor κB, not Pregnane X Receptor, in Inflammation-Mediated Regulation of Hepatic Transporters"." 10/01/2017 - "Involvement of Nuclear Factor κB, not Pregnane X Receptor, in Inflammation-Mediated Regulation of Hepatic Transporters."
4.	Cholestasis 02/01/2010 - "Clinical studies have shown that several activators of the pregnane X receptor (PXR) may induce the remission of cholestasis. " 08/01/2022 - "Pregnane X receptor (PXR) is a key regulator in endo- and xeno-biotics metabolism, which has been considered as a promising therapeutic target for cholestasis. " 07/08/2021 - "Pregnane X receptor (PXR) that orchestrates the intricate network of xeno- and endobiotic metabolism is considered as a promising therapeutic target for cholestasis. " 01/01/2021 - "Human pregnane-X-receptor (hPXR) is considered to be the key target for the treatment of cholestasis and liver injury. " 08/01/2016 - "Next-generation sequencing (NGS) of 24 cholestasis-related genes revealed a heterozygous two-basepair deletion in exon 1 of the pregnane X receptor gene (PXR). "
5.	Breast Neoplasms (Breast Cancer) 10/20/2021 - "High Pregnane X Receptor (PXR) Expression Is Correlated with Poor Prognosis in Invasive Breast Carcinoma." 10/15/2020 - "Associations between Pregnane X Receptor and Breast Cancer Growth and Progression." 04/01/2014 - "Effect of pregnane X receptor expression on drug resistance in breast cancer." 07/01/2009 - "Regulation of drug resistance by human pregnane X receptor in breast cancer." 01/05/2009 - "Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells."

Related Drugs and Biologics

1.	Cytochrome P-450 CYP3A
2.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
3.	Xenobiotics
4.	Messenger RNA (mRNA)
5.	Sorafenib (BAY 43-9006)
6.	Constitutive Androstane Receptor
7.	Proteins (Proteins, Gene)
8.	Enzymes
9.	Cytochrome P-450 Enzyme System (Cytochrome P450)
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Therapeutics
2.	Fat-Restricted Diet (Diet, Fat Restricted)
3.	Drug Therapy (Chemotherapy)
4.	Adjuvant Chemotherapy
5.	Kidney Transplantation