Cetrimonium (CTAB)

Cetyltrimethylammonium compound whose salts and derivatives are used primarily as topical antiseptics.

Also Known As:

CTAB; 1-Hexadecyltrimethylammonium Chloride; CTAOH; Cetavlon; Cetrimide; Cetriminium; Cetrimonium Bromide; Cetrimonium Chloride; Cetrimonium Hydroxide; Cetrimonium Iodide; Cetrimonium Methosulfate; Cetrimonium Methyl Sulfate; Cetrimonium Monosulfate; Cetyltrimethylammonium Bromide; Cetyltrimethylammonium Chloride; HTAB Cpd; Hexadecyl Trimethyl Ammonium Bromide; Hexadecyl(trimethyl)azanium; Hexadecyltrimethylammonium Bromide; Hexadecyltrimethylammonium Octylsulfonate; Octylsulfonate, Hexadecyltrimethylammonium; 1-Hexadecanaminium, N,N,N-trimethyl-

Networked: 223 relevant articles (15 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Quaternary Ammonium Compounds: 136
    - Trimethyl Ammonium Compounds: 1
      - Cetrimonium Compounds
        Cetrimonium: 223
- Onium Compounds
  - Quaternary Ammonium Compounds: 136
    - Cetrimonium Compounds
      - Cetrimonium: 223

Experts

1.	Huang, Fu-Mei: 5 articles (12/2021 - 07/2019)
2.	Lee, Chia-Jen: 5 articles (12/2021 - 07/2019)
3.	Pan, Ying-Ru: 5 articles (12/2021 - 07/2019)
4.	Chen, Chung-Hung: 4 articles (12/2021 - 07/2019)
5.	Chen, Yi-Ping: 3 articles (12/2021 - 08/2020)
6.	Wu, Tsai-Kun: 3 articles (08/2021 - 07/2019)
7.	Bosward, K L: 3 articles (03/2011 - 01/2011)
8.	Canfield, P J: 3 articles (03/2011 - 01/2011)
9.	Hunt, G B: 3 articles (03/2011 - 01/2011)
10.	Lepherd, M L: 3 articles (03/2011 - 01/2011)

Related Diseases

1.	Infections 06/25/2023 - "Overall, these results support the efficacy of MPSi-CTAB with potential application in the treatment and/or prevention of infections caused by methicillin-resistant Staphylococcus and/or Candida species." 01/01/2003 - "We found that the transient expression activity of luciferase could not be augmented directly by CTAB treatment alone, but could be enhanced more than 2 times by BmNPV treatment alone at a multiplicity of infection (MOI) of 0.5. " 06/01/1993 - "Little cross-reactivity with other common porcine helminth infections appeared only when ELISA was carried out with CSLE and CTAB antigens." 11/01/1986 - "CTAB antigen preparations were shown to be protective in NIH mice against a challenge infection as assessed by reduction in intestinal worm burden, worm fecundity, worm length and muscle larvae burden. " 01/01/2016 - "In contrast, microbicides such as cetrimide (CT) and chlorhexidine (CHX) play important roles in the prevention and treatment of infections. "
2.	Neoplasms (Cancer) 01/01/2023 - "Subsequently, the diffused CTAB and LPO will continue to attack the mitochondrial membranes and cell membranes, resulting in the death of different types of tumor cells both in vitro and in vivo due to membrane damage. " 07/15/2015 - "Furthermore, the PTX/TET-CTAB@MSN suppressed tumor cells growth more efficiently than only delivery of PTX (PTX-CTAB@MSN) or the free PTX. " 03/01/2012 - "This was significantly less than the tumor incidence (100%) in cuts made with inoculated blades not treated BC or CTAB." 10/01/2011 - "The in vitro cytotoxicity of CTAB-NES to the CHO cells and MCF-7 cells increased consistently with concentrations and was higher than that of NES, especially to the cancer cells. " 10/01/2011 - "The nano-MDDS DOX@CTAB@MSNs had a highly precise pH-responsive drug release behavior both in vitro and in vivo, and exhibited high drug efficiencies against drug-resistant MCF-7/ADR cells as well as drug-sensitive MCF-7 cells by the MSNs-mediated transmembrane delivery, the sustained drug release and the high anti-cancer and multi-drug resistance (MDR)-overcoming efficiencies. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "In this study, we hypothesized that AMPK as a key metabolic regulator plays a crucial role in regulation of breast cancer drug resistance, which could be alleviated by treatment of CTAB. " 01/01/2019 - "CTAB Enhances Chemo-Sensitivity Through Activation of AMPK Signaling Cascades in Breast Cancer." 01/01/2019 - "Taken together, our results showed that CTAB sensitized drug resistance of breast cancer to DOX chemotherapy by activating AMPK signaling cascades both in vitro and in vivo, suggested that CTAB may be developed as a promising and novel chemosensitizer and chemotherapeutic candidate for breast cancer treatment." 01/01/2019 - "We observed that CTAB can improve the DOX sensitivity of the breast cancer cells by inhibition of the ATP-dependent drug-efflux pump P-gp complex through activation of the AMPK-HIF-1α-P-gp cascades. " 11/09/2021 - "Similarly, the gelatin@Au-NRs showed an improved heat production and outstanding cell viability against two different cancer cell lines; KM-Luc/GFP (mouse fibroblast histiocytoma cell line) and FM3A-Luc (breast carcinoma cell line) compared to CTAB capped Au-NRs and PEG@Au-NRs. "
4.	Wounds and Injuries (Trauma) 03/01/2011 - "Both mulesing and the cetrimide-intradermal treatment induce a similar amount of wound bed contraction, with less contraction observed after application of clips." 03/01/2011 - "Mulesing wounds healed faster in the first 11 days, but by 19 days wound healing was similar between the mulesing and cetrimide-intradermal groups. " 03/01/2011 - "To quantify wound healing using a scoring system and to assess the contractility of the wound bed of the breech after mulesing, cetrimide-intradermal treatment and application of clips. " 09/24/1966 - "Experimental use of cetrimide in the prevention of wound implantation with cancer cells." 09/01/1966 - "Cetrimide as an irrigant in wounds seeded with cancer."
5.	Smear Layer 10/01/2012 - "In part 1, cementum was removed semicircumferentially from 21 roots, and the smear layer was removed from 15 roots using 17% EDTA/cetrimide. " 01/01/2013 - "Comparative evaluation of 15% ethylenediamine tetra-acetic acid plus cetavlon and 5% chlorine dioxide in removal of smear layer: A scanning electron microscope study." 04/01/2018 - "To evaluate the smear layer removal and wettability of AH Plus sealer on root canal dentin treated with MA (maleic acid), MA + CTR (cetrimide) and MA + CTR + CHX (chlorhexidine) as final irrigating regimens. " 01/01/2011 - "In the present investigation, a scanning electron microscopy analysis was performed to evaluate the effects of the topical application of ethylenediaminetetraacetic acid (EDTA) gel associated with Cetavlon (EDTAC) in removing the smear layer and exposing collagen fibers following root surface instrumentation. " 04/01/2008 - "Following the creation of standardized smear layer co-site microscopy image sequences of the dentine surface submitted to EDTA, EDTA plus 0.1% cetavlon (Sigma Chemical Co., St Louis, MO, USA), EDTA plus 1.25% sodium lauryl ether sulphate and SmearClear (Sybron Endo, Orange, CA, USA) were obtained after several cumulative demineralization times. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Cetrimonium (CTAB)
3.	Chlorhexidine
4.	Lidocaine (Xylocaine)
5.	Bupivacaine (Bupivacaine Hydrochloride)
6.	Acids
7.	Epinephrine (Adrenaline)
8.	Surface-Active Agents (Surfactants)
9.	EDTAC
10.	Solutions

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Catheters
4.	Lasers (Laser)
5.	Nanospheres