Vinorelbine (Navelbine)

A vinca alkaloid related to VINBLASTINE that is used as a first-line treatment for NON-SMALL CELL LUNG CANCER, or for advanced or metastatic BREAST CANCER refractory to treatment with ANTHRACYCLINES.

Also Known As:

Networked: 2464 relevant articles (402 outcomes, 1120 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Gebbia, Vittorio: 16 articles (12/2021 - 01/2002)
2.	Gridelli, Cesare: 15 articles (07/2014 - 04/2002)
3.	Seymour, Lesley: 14 articles (01/2019 - 08/2003)
4.	Shepherd, Frances A: 14 articles (01/2019 - 08/2003)
5.	Yamamoto, Nobuyuki: 13 articles (01/2022 - 08/2006)
6.	Georgoulias, V: 13 articles (04/2015 - 01/2001)
7.	Goldhirsch, A: 13 articles (09/2009 - 01/2000)
8.	Seto, Takashi: 11 articles (01/2022 - 05/2002)
9.	Xu, Binghe: 11 articles (07/2021 - 01/2010)
10.	Lorusso, V: 11 articles (11/2014 - 01/2000)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 04/01/2012 - "Taken together, these data indicate that oral vinorelbine is a highly effective and well tolerated agent which can be used in first-line and subsequent metastatic breast cancer settings. " 01/01/1999 - "Vinorelbine (VNR) is highly active in metastatic breast cancer (MBC) and has shown an overall response rate of 40%-50% as first-line treatment. " 05/01/1998 - "Vinorelbine (VNR) is highly active in metastatic breast cancer (MBC) and has shown an overall response rate of 40%-50% as first-line treatment. " 01/01/2021 - "Metronomic vinorelbine is an excellent and safe treatment for advanced breast cancer: a retrospective, observational study." 04/01/2006 - "In addition,we explain why it took 17 years for vinorelbine to be approved despite the fact that as early as the beginning of development, it was scientifically proven to be very useful in patients with breast cancer, and that the new drug application was submitted in 1993. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/01/2000 - "There is a high level of evidence that vinorelbine is an effective agent for the treatment of non-small-cell lung cancer." 09/01/2022 - "An increasing body of evidence from clinical trials and real-world studies suggests that metronomic oral vinorelbine (VNR) is a promising treatment option for elderly and unfit advanced non-small cell lung cancer (NSCLC) patients. " 10/01/1999 - "Combinations of vinorelbine with other nonplatinum agents show promising results in phase I and phase II trials in non-small cell lung cancer (NSCLC). " 05/06/2015 - "Metronomic oral vinorelbine could be a safe option for elderly patients with advanced non small cell lung cancer (NSCLC). " 05/06/2015 - "Metronomic oral vinorelbine as first-line treatment in elderly patients with advanced non-small cell lung cancer: results of a phase II trial (MOVE trial)."
3.	Neoplasms (Cancer) 01/01/2018 - "Vinorelbine showed a good safety profile at different doses taken orally and was effective in controlling cancer progression. " 05/01/2010 - "Compared with free vinorelbine (Free Vino), M-Vino was more effective in inhibiting the growth of tumor cells in vitro, inducing G(2)/M phase arrest and apoptosis of tumor cells. " 06/01/2015 - "Vinorelbine appeared to be effective in the treatment of several tumor types in dogs. " 05/01/1999 - "Vinorelbine is effective in the treatment of a number of malignancies. " 04/03/2020 - "Vinorelbine improved HCC tumor response to standard irradiation with no increase in toxicity. "
4.	Lung Neoplasms (Lung Cancer) 03/01/2012 - "In RM-1/BDF1 and Lewis lung cancer/c57 models, antitumor efficacy was also considerably improved after vinorelbine encapsulation into 5ssa vesicles. " 11/01/2000 - "[Improvement in quality of life with vinorelbine as a single agent in two patients with recurrent lung cancer]." 01/01/2022 - "Revisiting metronomic vinorelbine with mathematical modelling: a Phase I trial in lung cancer." 10/01/2018 - "This study investigated the effects of oral vinorelbine given every other day without interruption and its pharmacokinetic profile in patients with advanced lung cancer. " 01/01/2013 - "In this study, we explored effects of vinorelbine in multi-drug resistance reversal of human lung cancer A549/DDP cells. "
5.	Carcinoma (Carcinomatosis) 12/01/2009 - "Therapeutic efficacy evaluation of 111In-labeled PEGylated liposomal vinorelbine in murine colon carcinoma with multimodalities of molecular imaging." 01/01/2005 - "Evaluation of vinorelbine in persistent or recurrent nonsquamous carcinoma of the cervix: a Gynecologic Oncology Group Study." 01/01/2002 - "Vinorelbine in elderly patients with inoperable nonsmall cell lung carcinoma: a Phase II study." 06/15/2000 - "The purpose of this Phase II trial was to make a comprehensive evaluation of the activity, toxicity, and tolerability of single-agent vinorelbine in elderly and relatively poorly performing patients with inoperable nonsmall cell lung carcinoma (NSCLC). " 06/15/2000 - "Vinorelbine in elderly patients with inoperable nonsmall cell lung carcinoma: a phase II study."

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Gemcitabine
3.	Docetaxel (Taxotere)
4.	Paclitaxel (Taxol)
5.	Vinorelbine (Navelbine)
6.	Capecitabine (Xeloda)
7.	Anthracyclines
8.	Trastuzumab (Herceptin)
9.	Carboplatin (JM8)
10.	Fluorouracil (Carac)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Adjuvant Chemotherapy
5.	Neoadjuvant Therapy