Zoledronic Acid (Zometa)

An imidobisphosphonate inhibitor of BONE RESORPTION that is used for the treatment of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.

Also Known As:

Zometa; 2-(Imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid; CGP 42'446; CGP 42446A; CGP-42'446; CGP-42446; Zoledronate; Zoledronic Acid Anhydrous; CGP 42446; CGP42'446; CGP42446

Networked: 3599 relevant articles (464 outcomes, 952 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Lipton, Allan: 59 articles (04/2022 - 01/2002)
2.	Saad, Fred: 57 articles (04/2022 - 01/2002)
3.	Coleman, Robert E: 50 articles (08/2021 - 12/2002)
4.	Reid, Ian R: 32 articles (01/2022 - 02/2002)
5.	Terpos, Evangelos: 30 articles (06/2021 - 07/2006)
6.	Body, Jean-Jacques: 28 articles (02/2019 - 02/2002)
7.	Santini, Daniele: 25 articles (10/2019 - 08/2003)
8.	Smith, Matthew R: 25 articles (12/2016 - 06/2003)
9.	Caraglia, Michele: 23 articles (10/2018 - 09/2004)
10.	Boonen, Steven: 22 articles (12/2014 - 05/2007)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 01/01/2004 - "Zoledronic acid was significantly more effective than placebo on most efficacy measures in patients with bone metastases secondary to other solid tumours (e.g. " 04/01/2017 - "Zoledronic acid (ZA) has been shown to be effective for the treatment of bone metastases regardless of whether the bone lesions are osteolytic or osteoblastic. " 08/01/2014 - "However, zoledronic acid does reduce the development of bone metastases and, for women with established menopause, improved disease outcomes. " 01/01/2014 - "The inhibitory efficacy of Zoledronic acid (ZA) on Edu-macrophage-enhanced metastasis was also determined. " 05/01/2013 - "Zoledronic acid has demonstrated efficacy in the reduction and delay of SREs in patients with bone metastases. "
2.	Neoplasms (Cancer) 02/01/2014 - "However, RANKL inhibition reduced skeletal growth of MDA-231-RANK tumors to a significantly greater extent than zoledronic acid, indicating that skeletal growth of RANK-positive tumors is also driven by direct RANKL effects. " 01/01/2023 - "Zoledronate seems to be effective in the treatment of hypercalcaemia of malignancy." 10/13/2015 - "Our work proposes nanoparticle formulations of zoledronic acid as the first not toxic metabolic modifiers, effective against MDR tumors. " 03/01/2010 - "Development of new treatment for metastatic bone tumors is awaited, but there is a possibility of inappropriate use as with zoledronic acid because of lack of knowledge and experience. " 05/01/2013 - "We have previously demonstrated in a murine model of PDAC that zoledronic acid (ZA) depletes G-MDSC resulting in decreased tumor growth and improved survival. "
3.	Prostatic Neoplasms (Prostate Cancer) 05/01/2012 - "Zoledronic acid was found to be cost effective in all European countries across all three indications but not in the sole global prostate cancer analysis. " 01/01/2010 - "Zoledronic acid treatment promoted effective osseous protection against the natural demineralization process in patients with prostate cancer recurrence submitted to ADT." 10/01/2002 - "The objective of this study was to evaluate the efficacy of zoledronate in limiting the formation and/or progression of osteoblastic lesions produced by the injection of known prostate cancer cells (LAPC-9 and PC-3 cells) into the tibia of SCID mice. " 01/01/2022 - "Do disease status and race affect the efficacy of zoledronic acid in patients with prostate cancer? " 01/01/2017 - "Zoledronic Acid in First-Line Treatment of Prostate Cancer."
4.	Osteoporosis 06/01/2016 - "Zoledronic acid ranked as the most effective in preventing vertebral fracture in primary osteoporosis. " 01/01/2013 - "Once-yearly zoledronic acid has been proven effective in the management of osteoporosis. " 02/01/2017 - "This randomized, double-blind, placebo-controlled study assessed the necessity of early intervention, safety and efficacy of intravenous zoledronic acid 5 mg/year in East China women with newly diagnosed osteoporosis at high risk of fracture during a 24-month treatment period. " 02/05/2022 - "Compared with Group 1 (osteoporosis with IV zoledronate injection) Group 2 (normal bone density) showed significant improvement in their University of California, Los Angeles (UCLA) shoulder score and Constant Shoulder Score (CSS) at 6 months postoperatively. " 07/01/2023 - "This study positions CT2S as a potential novel osteoporosis-screening tool for secondary fracture prevention in the clinical setting.A shorter screening interval of 2 y increases the effectiveness of both screening strategies, but the ICER of CT2S compared with DXA also increased substantially, which made CT2S no longer cost-effective for the 70s age group; however, it remains cost-effective for individuals in their 80s.Annual zoledronic acid treatment with better adherence may contribute to a lower cost-effectiveness ratio when comparing CT2S to DXA screening and the treat all strategies for all age groups."
5.	Breast Neoplasms (Breast Cancer) 02/01/2012 - "Clinical data from large, phase 3 trials (ie, ABCSG-12, ZO-FAST, and AZURE) demonstrate significantly improved disease-free survival with zoledronic acid in some patient populations with early breast cancer. " 11/01/2011 - "Moreover, clinical data from the ABCSG-12 and ZO-FAST trials demonstrate significantly improved disease-free survival with zoledronic acid in the adjuvant breast cancer setting. " 06/26/2012 - "Effect of (Neo)adjuvant zoledronic acid on disease-free and overall survival in clinical stage II/III breast cancer." 05/01/2009 - "Zoledronic acid protected patients with breast cancer against bone loss during initial treatment, whereas home-based PA interventions were less effective in preventing bone loss." 02/14/2015 - "Neo-adjuvant breast cancer clinical trials of zoledronic acid (ZOL) have shown that patients with oestrogen negative (ER-ve) tumours have improved disease outcomes. "

Related Drugs and Biologics

1.	Diphosphonates (Bisphosphonates)
2.	Denosumab
3.	Pamidronate (Aredia)
4.	Hormones (Hormone)
5.	Alendronate (Alendronate Sodium)
6.	Clodronic Acid (Clodronate)
7.	Zoledronic Acid (Zometa)
8.	Androgens
9.	Docetaxel (Taxotere)
10.	Risedronic Acid (Actonel)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Castration
5.	Neoadjuvant Therapy