Abstract | INTRODUCTION:
Osteoporosis is an under-recognized problem threatening men. Bisphosphonates are the main treatment but their comparative efficacy is unclear for men with osteoporosis. Therefore, we performed this systematic review with network meta-analyses to summarize the evidence of comparative efficacy of bisphosphonates in men with osteoporosis. METHODS: We completed network meta-analyses with a frequentist model to compare the efficacy of different bisphosphonates. Randomized controlled trials investigating bisphosphonates used in men with osteoporosis were included. The primary outcome was the rate of patients with a new vertebral fracture. The secondary outcome was the rate of patients with a non-vertebral fracture, which was defined as any fractures reported other than vertebral fractures. Pairwise meta-analyses were performed to compare bisphosphonates with placebo. We included open-label studies in the analyses as a sensitivity analysis. RESULTS: CONCLUSION:
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Authors | Junwen Zhou, Tiansheng Wang, Xilan Zhao, Donald R Miller, Suodi Zhai |
Journal | Rheumatology and therapy
(Rheumatol Ther)
Vol. 3
Issue 1
Pg. 117-128
(Jun 2016)
ISSN: 2198-6576 [Print] England |
PMID | 27747517
(Publication Type: Journal Article)
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