Sugammadex

A gamma-cyclodextrin that functions as a reversal agent for the neuromuscular blocker ROCURONIUM BROMIDE.

Also Known As:

6-Perdeoxy-6-per(2-carboxyethyl)thio-gamma-cyclodextrin sodium salt; Bridion; Org 25969; Sugammadex Sodium; Gamma-cyclodextrin, 6A,6B,6C,6D,6E,7F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,7F,6G,6H-octathio-

Networked: 636 relevant articles (50 outcomes, 91 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carron, Michele: 10 articles (01/2021 - 08/2012)
2.	de Boer, Hans D: 10 articles (01/2021 - 08/2007)
3.	Tobias, Joseph D: 9 articles (01/2022 - 07/2017)
4.	Takazawa, Tomonori: 7 articles (06/2021 - 01/2014)
5.	Brull, Sorin J: 7 articles (12/2020 - 01/2009)
6.	Hancı, Volkan: 7 articles (01/2020 - 06/2016)
7.	Yang, Hong Seuk: 6 articles (04/2022 - 10/2019)
8.	Blobner, Manfred: 6 articles (10/2021 - 10/2009)
9.	Orihara, Masaki: 6 articles (06/2021 - 01/2014)
10.	Naguib, Mohamed: 6 articles (01/2016 - 03/2007)

Related Diseases

1.	Anaphylaxis (Anaphylactic Shock) 07/01/2022 - "Based on the findings of this review, there appears to be a rare, but serious, association of sugammadex-induced perioperative anaphylaxis with an incidence between 0.02 and 0.04% in observational studies. " 07/21/2021 - "During the study period, 1,401,630 sugammadex vials were sold, and 19 cases of sugammadex-induced anaphylaxis were identified in the KIDS-KAERS database. " 06/05/2021 - "Although many cases of sugammadex-induced anaphylaxis have been reported, few studies have investigated the underlying mechanism. " 04/01/2021 - "In total, 23 suitable articles were found and 33 sugammadex-induced anaphylaxis cases were included in the study. " 01/01/2018 - "However, few studies have investigated the utility of the BAT for sugammadex-induced anaphylaxis. "
2.	Delayed Emergence from Anesthesia 11/01/2015 - "After abdominal surgery, sugammadex reversal eliminated residual neuromuscular blockade in the PACU, and shortened the time from start of study medication administration to the time the patient was ready for discharge from the operating room. " 01/01/2023 - "Although sugammadex is well known for its use in reducing the incidence of residual neuromuscular blockade, this has not always been translated to improved clinical measures of postoperative respiratory muscle strength. " 01/01/2022 - "Our study showed that there was a 200% increase in the MEP amplitude in the first dorsal interosseous muscle at 3 min following reversal of residual neuromuscular blockade with sugammadex. " 11/01/2015 - "Effects of sugammadex on incidence of postoperative residual neuromuscular blockade: a randomized, controlled study." 08/01/2023 - "Use an acceleration muscle relaxation monitor for muscle relaxation monitoring, and administer neostigmine+atropine and sugammadex to block residual muscle relaxation drugs after surgery. "
3.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/2023 - "Considering the small number of clinical studies, high heterogeneity amongstudies, and insufficient safety information, more extensive data on the efficacy and safetyof sugammadex in patients with ESRD are needed. " 10/01/2022 - "Postoperative mortality in patients with end-stage renal disease according to the use of sugammadex: a single-center retrospective propensity score matched study." 10/01/2008 - "Multicentre, parallel-group, comparative trial evaluating the efficacy and safety of sugammadex in patients with end-stage renal failure or normal renal function." 01/01/2023 - "Furthermore,anesthesiologists should remember that performing proper quantitative neuromuscularmonitoring and neuromuscular management based on the monitoring signs are the mostessential requirements when using sugammadex in patients with ESRD." 01/01/2023 - "Due to unknown safety concerns, sugammadex should not be administered to patients withend-stage renal disease (ESRD). "
4.	Paralysis (Palsy) 01/01/2022 - "While sugammadex has been shown to be effective in minimising residual paralysis, uncertainty exists as to whether its use reduces any associated morbidity. " 01/01/2023 - "Two patients required additional sugammadex administration for recurrent paralysis. " 01/01/2023 - "The hypothesis was that many patients would require less than the recommended dose of sugammadex, but that some would require more, and that recurrent paralysis would not occur. " 01/01/2023 - "Reversing neuromuscular blockade with sugammadex can eliminate residual paralysis, which has been associated with postoperative respiratory complications. " 03/01/2022 - "We describe monitor troubleshooting, considerations with unexpectedly deep neuromuscular blockade, the importance of routine quantitative neuromuscular monitoring, and one strategy for sugammadex reversal in patients with profound paralysis outside of the standard dosing guidelines."
5.	Postoperative Nausea and Vomiting (PONV) 02/01/2015 - "Comparison of sugammadex and conventional reversal on postoperative nausea and vomiting: a randomized, blinded trial." 01/01/2024 - "Regarding PONV, the use of sugammadex for NMB antagonism may offer a better option for pediatric patients." 01/01/2023 - "After IPTW adjustment, sugammadex use was associated with lower incidence of PONV (OR 0.54, 95% CI 0.48-0.61, P < 0.001), postoperative nausea (PON) (OR 0.77, 95% CI 0.67-0.88, P < 0.001), and postoperative vomiting (POV) (OR 0.60, 95% CI 0.53-0.68, P < 0.001) within postoperative 48 h. " 01/01/2023 - "In multivariable analysis, sugammadex use (OR 0.03, 95% CI 0.01-0.09, P < 0.001) was an independent protective factor of PONV. " 01/01/2023 - "Whether sugammadex use is related to the persistent decrease in the occurrence of PONV during postoperative inpatient hospitalization, which is critical for the rehabilitation of patients after LBS, remains unknown. "

Related Drugs and Biologics

1.	Rocuronium (Zemuron)
2.	Neostigmine (Neostigmine Bromide)
3.	Pyridostigmine Bromide (Pyridostigmine)
4.	Glycopyrrolate (Glycopyrronium Bromide)
5.	Antiemetics
6.	Vecuronium Bromide (Vecuronium)
7.	Opioid Analgesics (Opioids)
8.	Anti-Bacterial Agents (Antibiotics)
9.	Benzylisoquinolines
10.	Mannitol (Osmitrol)

Related Therapies and Procedures

1.	Anesthesia
2.	Renal Replacement Therapy (Therapies, Renal Replacement)
3.	Thoracoscopes
4.	Neuroanesthesia
5.	General Anesthesia