Unanticipated Profound Paralysis and Sugammadex Dosing Implications After Videoscopic Thoracic Surgery.

Abstract

A bedridden patient with empyema presented for thoracoscopic decortication. During the procedure, despite a post-tetanic count (PTC) of 0 via calibrated quantitative neuromuscular monitoring, persistent diaphragmatic movement impaired operating conditions, so rocuronium was re-dosed. After surgery, the patient had 0 PTC. Sugammadex was titrated to achieve baseline neuromuscular strength, monitoring the effect of each 200-mg dose. Ultimately, 1200 mg was required to achieve baseline strength. We describe monitor troubleshooting, considerations with unexpectedly deep neuromuscular blockade, the importance of routine quantitative neuromuscular monitoring, and one strategy for sugammadex reversal in patients with profound paralysis outside of the standard dosing guidelines.

• Authors: Melissa L McKittrick, Frederick W Lombard
• Journal: Seminars in cardiothoracic and vascular anesthesia (Semin Cardiothorac Vasc Anesth) Vol. 26 Issue 1 Pg. 86-89 (Mar 2022) ISSN: 1940-5596 [Electronic] United States
• PMID: 34889149 (Publication Type: Journal Article)

Chemical References

• Neuromuscular Nondepolarizing Agents
• gamma-Cyclodextrins
• Sugammadex

Topics

• Humans
• Neuromuscular Blockade (methods)
• Neuromuscular Nondepolarizing Agents
• Paralysis
• Sugammadex
• Thoracic Surgery
• gamma-Cyclodextrins