Centromere Protein A

A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.

Also Known As:

Networked: 22 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Feng, Xiao-Jun: 2 articles (04/2014 - 08/2012)
2.	Wang, Shou-Mei: 2 articles (04/2014 - 08/2012)
3.	Zhang, Shu-Hui: 2 articles (04/2014 - 08/2012)
4.	Wang, Li: 2 articles (03/2011 - 03/2007)
5.	Liu, Xiaolan: 1 article (01/2022)
6.	Wang, Haiping: 1 article (01/2022)
7.	Zhao, Guojun: 1 article (01/2022)
8.	Liang, Yi-Chao: 1 article (12/2021)
9.	Liu, Yu-Jie: 1 article (12/2021)
10.	Su, Qi: 1 article (12/2021)

Related Diseases

1.	Aneuploidy (Aneuploid) 12/10/2009 - "-transcriptional silencing of CENPA by RNA interference, resulting in CENP-A protein levels similar to those present in control cells greatly reduced aneuploid cell numbers in pRb-depleted cells. " 01/01/2019 - "Furthermore, whole-genome chromatin precipitation analysis reveals that Centromere Protein A/ Centromeric Histone H3-like Protein (CENP-A/Cse4), a centromeric histone H3 variant that forms the platform of the eukaryotic kinetochore, is depleted from tetraploid-mating products relative to diploid parents and is virtually eliminated from cells exposed to aneuploidy-promoting cues. "
2.	Tetraploidy 01/01/2019 - "Furthermore, whole-genome chromatin precipitation analysis reveals that Centromere Protein A/ Centromeric Histone H3-like Protein (CENP-A/Cse4), a centromeric histone H3 variant that forms the platform of the eukaryotic kinetochore, is depleted from tetraploid-mating products relative to diploid parents and is virtually eliminated from cells exposed to aneuploidy-promoting cues. "
3.	Neoplasms (Cancer) 01/01/2020 - "Recent studies have established the ability of centromere protein-A (CENP-A) to perform as an oncogene, regulating tumor progression. " 01/01/2022 - "Centromere Protein A Goes Far Beyond the Centromere in Cancers." 10/01/2013 - "Altered expression of centromere protein-A (CENP-A) is observed in various types of human cancers. " 08/01/2012 - "Centromere protein A (CENP-A), one of the fundamental components of the human active kinetochore, is frequently upregulated in many cancers and plays important roles in cell cycle regulation, cell survival, and genetic stability. " 01/01/2016 - "Elevated expression of the centromere protein-A(CENP-A)-encoding gene as a prognostic and predictive biomarker in human cancers."
4.	Hepatocellular Carcinoma (Hepatoma) 03/01/2007 - "To study the expression of centromere protein A (CENP-A) and its significance in hepatocellular carcinoma (HCC) and adjacent non-neoplastic liver tissue. " 03/01/2007 - "[Expression of centromere protein A in hepatocellular carcinoma]." 03/15/2011 - "ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth."
5.	Prostatic Neoplasms (Prostate Cancer) 10/01/2023 - "High expression of centromere protein A and its molecular mechanism and clinical significance in prostate cancer: A study based on data mining and immunohistochemistry."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Histones (Histone)
3.	Chromatin
4.	Biomarkers (Surrogate Marker)
5.	TOR Serine-Threonine Kinases
6.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
7.	Histone Chaperones
8.	Insulin Receptor Substrate Proteins
9.	Cruciform DNA (Holliday Junctions)
10.	Small Interfering RNA (siRNA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)