Fanconi Anemia Complementation Group N Protein
A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.
Also Known As:
FANCN Protein; PALB2 Protein; Partner and Localizer of BRCA2 Protein
Networked: 5
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Eshleman, James R:
2 articles
(01/2011 - 04/2009)
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2. | Hruban, Ralph H:
2 articles
(01/2011 - 04/2009)
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3. | Jones, Siân:
2 articles
(01/2011 - 04/2009)
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4. | Maitra, Anirban:
2 articles
(01/2011 - 04/2009)
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5. | Brahiti, Nadine:
1 article
(01/2019)
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6. | Dellaire, Graham:
1 article
(01/2019)
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7. | Deveryshetty, Jaigeeth:
1 article
(01/2019)
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8. | Korolev, Sergey:
1 article
(01/2019)
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9. | Masson, Jean-Yves:
1 article
(01/2019)
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10. | Peterlini, Thibaut:
1 article
(01/2019)
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