Fanconi Anemia Complementation Group N Protein

A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.

Also Known As:

FANCN Protein; PALB2 Protein; Partner and Localizer of BRCA2 Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nuclear Proteins: 2678
    - Fanconi Anemia Complementation Group N Protein: 5
  - Fanconi Anemia Complementation Group Proteins: 29
    - Fanconi Anemia Complementation Group N Protein: 5
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 1683
      - Fanconi Anemia Complementation Group N Protein: 5

mouse Palb2 protein

Bio-Agent Context: Research Results