Fanconi Anemia Complementation Group N Protein

A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Eshleman, James R: 2 articles (01/2011 - 04/2009)
2.	Hruban, Ralph H: 2 articles (01/2011 - 04/2009)
3.	Jones, Siân: 2 articles (01/2011 - 04/2009)
4.	Maitra, Anirban: 2 articles (01/2011 - 04/2009)
5.	Brahiti, Nadine: 1 article (01/2019)
6.	Dellaire, Graham: 1 article (01/2019)
7.	Deveryshetty, Jaigeeth: 1 article (01/2019)
8.	Korolev, Sergey: 1 article (01/2019)
9.	Masson, Jean-Yves: 1 article (01/2019)
10.	Peterlini, Thibaut: 1 article (01/2019)

Related Diseases

1.	Fanconi Anemia (Fanconi's Anemia) 12/15/2012 - "The PALB2 protein is associated with breast cancer susceptibility and Fanconi anemia. " 06/01/2011 - "The Partner and Localizer of BRCA2 (PALB2) protein has been linked to Fanconi anemia and breast cancer predisposition. " 01/01/2019 - "BReast Cancer Associated proteins 1 and 2 (BRCA1, -2) and Partner and Localizer of BRCA2 (PALB2) protein are tumour suppressors linked to a spectrum of malignancies, including breast cancer and Fanconi anemia. "
2.	Breast Neoplasms (Breast Cancer) 12/15/2012 - "The PALB2 protein is associated with breast cancer susceptibility and Fanconi anemia. " 06/01/2011 - "The Partner and Localizer of BRCA2 (PALB2) protein has been linked to Fanconi anemia and breast cancer predisposition. " 01/01/2019 - "BReast Cancer Associated proteins 1 and 2 (BRCA1, -2) and Partner and Localizer of BRCA2 (PALB2) protein are tumour suppressors linked to a spectrum of malignancies, including breast cancer and Fanconi anemia. "
3.	Neoplasms (Cancer) 01/01/2011 - "Global genomic sequencing revealed biallelic inactivation of the gene encoding PalB2 protein in this patient's cancer; the mutation is predicted to disrupt BRCA1 and BRCA2 interactions critical to DNA double-strand break repair. " 01/01/2019 - "BReast Cancer Associated proteins 1 and 2 (BRCA1, -2) and Partner and Localizer of BRCA2 (PALB2) protein are tumour suppressors linked to a spectrum of malignancies, including breast cancer and Fanconi anemia. "
4.	Familial Breast Cancer 04/10/2009 - "PALB2 mutations have been previously reported in patients with familial breast cancer, and the PALB2 protein is a binding partner for BRCA2. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	DNA (Deoxyribonucleic Acid)