CXCR6 Receptors

CXCR receptors that are specific for CHEMOKINE CXCL16. They are expressed by lymphoid tissues, activated T-cells, and also function as co-receptors for SIMIAN IMMUNODEFICIENCY VIRUSES; HIV-2; and HIV-1 infection of MACROPHAGES.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fujino, Naoya: 1 article (11/2019)
2.	Fujishima, Fumiyoshi: 1 article (11/2019)
3.	Ichinose, Masakazu: 1 article (11/2019)
4.	Inoue, Akira: 1 article (11/2019)
5.	Itakura, Koji: 1 article (11/2019)
6.	Kyogoku, Yorihiko: 1 article (11/2019)
7.	Miyauchi, Eisaku: 1 article (11/2019)
8.	Okada, Yoshinori: 1 article (11/2019)
9.	Okazaki, Tatsuma: 1 article (11/2019)
10.	Okutomo, Koji: 1 article (11/2019)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 02/09/2016 - "In this study, we show involvement of CXC chemokine receptor 6 (CXCR6) and its only natural ligand CXCL16 in pathobiology of prostate cancer (PCa). "
2.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/2016 - "This study aimed to determine the effects of the CXC chemokine ligand 16 (CXCL16)/CXC chemokine receptor 6 (CXCR6) pathway on cholesterol accumulation in the radial arteries of end-stage renal disease (ESRD) patients with concomitant microinflammation and to further investigate the potential effects of the purinergic receptor P2X ligand-gated ion channel 7 (P2X7R). "
3.	Osteosarcoma (Osteogenic Sarcoma) 03/01/1999 - "We tested 11 primary HIV-2 isolates for coreceptor usage in human cell lines: U87 glioma cells, stably expressing CD4 and the chemokine receptor CCR1, CCR2b, CCR3, CCR5, or CXCR4, and GHOST(3) osteosarcoma cells, coexpressing CD4 and CCR5, CXCR4, or the orphan receptor Bonzo or BOB. " 12/05/2001 - "Sequential isolates from eight cynomolgus monkeys experimentally infected with simian immunodeficiency virus (SIVsm, of sooty mangabey origin) were tested for coreceptor use in the human osteosarcoma indicator cell line, GHOST(3), expressing CD4 and one or another of the chemokine receptors CCR3, CCR5, CXCR4, BOB, or the orphan receptor Bonzo. "
4.	Chronic Obstructive Pulmonary Disease (COPD) 09/01/2007 - "CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity."
5.	Neoplasms (Cancer) 12/01/2017 - "Accumulating evidence indicates that CXC chemokine receptor 6 (CXCR6) has a crucial role in cancer development and progression, however, its role in clear cell renal cell carcinoma (ccRCC) remains obscure. "

Related Drugs and Biologics

1.	Purinergic P2X7 Receptors
2.	Ligands
3.	Cholesterol
4.	Chemokine CXCL16
5.	Chemokine Receptors
6.	ErbB Receptors (EGF Receptor)
7.	CCR5 Receptors (CCR5 Receptor)
8.	Chemokines
9.	Proteins (Proteins, Gene)
10.	Indicators and Reagents (Reagents)