S100 Calcium Binding Protein A7

An S100 calcium binding protein that contains two EF HAND MOTIFS and also binds zinc. It is secreted via a non-classical secretory pathway and expressed by KERATINOCYTES and epithelial cells of the tongue. It has antimicrobial and immunomodulatory activities and is highly expressed in the skin of patients with PSORIASIS, as well as in bladder and skin epithelial carcinomas.

Also Known As:

Networked: 190 relevant articles (4 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wolf, Ronald: 13 articles (01/2017 - 07/2008)
2.	Harder, Jürgen: 11 articles (07/2021 - 01/2005)
3.	Watson, Peter H: 10 articles (12/2009 - 11/2002)
4.	Gläser, Regine: 9 articles (07/2021 - 01/2005)
5.	Ruzicka, Thomas: 8 articles (01/2017 - 12/2010)
6.	Enerbäck, Charlotta: 7 articles (04/2017 - 01/2002)
7.	Murphy, Leigh C: 7 articles (08/2007 - 11/2002)
8.	Jiang, Wen G: 6 articles (01/2020 - 07/2004)
9.	Ye, Lin: 6 articles (01/2020 - 12/2012)
10.	Zwicker, Stephanie: 6 articles (01/2017 - 05/2012)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 04/06/2017 - "The aim of this study was to investigate the effect of endogenous psoriasin on disturbed keratinocyte differentiation in psoriasis. " 05/01/2020 - "A potential association between psoriasin to rs4819554 of IL-17RA gene polymorphism in psoriasis Egyptian patients." 01/01/2020 - "Psoriasin and rs4819554 of IL-17RA gene polymorphism in psoriasis." 01/01/2020 - "Psoriasin (S100A7) is increased in the serum of patients with moderate-to-severe psoriasis." 04/01/2018 - "Compared with HCs, patients with psoriasis had significantly higher levels of psoriasin (26.61 ± 22.45 ng/mL vs. 6.31 ± 1.68 ng/mL, P < 0.001) and koebnerisin (21.2 ± 13.12 ng/mL vs. 12.2 ± 4.67 ng/mL, P = 0.001), and significantly higher IMT values (1.07 ± 0.4 mm vs. 0.61 ± 0.1 mm, P < 0.001). "
2.	Breast Neoplasms (Breast Cancer) 07/01/2004 - "The most interesting observation is that levels of psoriasin were significantly higher in patients who developed metastatic disease and in patients who died of breast cancer (p=0.02 and p<0.001, vs disease-free, respectively). " 07/01/2003 - "This study explores the clinical significance of psoriasin in relation to patient survival in invasive breast cancer. " 07/01/2012 - "Psoriasin may therefore play a role in breast cancer progression by promoting oxidative stress response and angiogenesis." 05/08/2009 - "Human S100A7 (psoriasin) is considered a marker for specific stages of breast cancer. " 11/06/2007 - "In contrast, in the SUM190 breast carcinoma cell line, IFN-gamma did not suppress the expression of endogenous psoriasin. "
3.	Inflammation (Inflammations) 10/01/2021 - "FLG-related events in response to S100A7 protein may represent novel therapeutic targets for the treatment of upper airway inflammation." 01/01/2017 - "Inflammation modifies the compartmentation of RIS-1/psoriasin in sebaceous glands and the follicular root sheaths. " 12/08/2010 - "Inflammation-prone psoriatic skin constitutively expresses elevated concentrations of S100A7 (psoriasin) and S100A15 (koebnerisin) in the epidermis. " 04/01/2007 - "The expression of psoriasin in human skin tumours seems to be independent from differentiation and inflammation." 04/01/2007 - "Psoriasin (S100A7) has originally been described to be expressed by psoriatic keratinocytes possibly as a result of altered differentiation and inflammation. "
4.	Infections 03/01/2014 - "Similarly, psoriasin was seen more often in the upper skin layers of both infections as compared with normal skin. " 07/14/2010 - "Psoriasin thus appears to be a part of the local host defence mechanisms in the udder and seems to be inducible by infection with E. " 03/01/2009 - "The upregulation of psoriasin in AD maybe induced by the disrupted skin barrier offering a possible explanation why these patients do not suffer from skin infections with E. " 03/01/2009 - "coli infections are not observed in atopic skin we investigated the functional role of psoriasin in AD patients. " 01/01/2018 - "Out of six studied AMPs, psoriasin was most up-regulated during a mucosal infection, an acute episode of recurrent Candida vulvovaginitis, although candidacidal activity has not been demonstrated. "
5.	Refsum Disease (Refsum's Disease) 10/01/2018 - "We suggest that LB polymorphism reflects a wide array of barrier adaptations to environmental challenges, rather than just a defective barrier function, based on observations on a) LB morphology in inherited skin disorders of lipid metabolism (Refsum disease, Chanarin-Dorfman syndrome) characterized by deficiency of lamellar lipids and accumulation of toxic metabolites; b) Psoriasis (with a high expression of Psoriasin antimicrobial peptide within lesions) and c) the Pitohui, a toxic bird where diet-derived toxin is eliminated via the LB secretory system that creates a chemical defense system. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Messenger RNA (mRNA)
3.	Cytokines
4.	Chemokines
5.	Antimicrobial Peptides
6.	Defensins
7.	involucrin
8.	Peptides (Polypeptides)
9.	Filaggrin Proteins
10.	Caspase 14

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics