High-Temperature Requirement A Serine Peptidase 2

A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.

Also Known As:

Networked: 45 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Behbahani, Homira: 3 articles (07/2019 - 04/2011)
2.	Kang, Seongman: 3 articles (01/2017 - 02/2004)
3.	Rhim, Hyangshuk: 3 articles (01/2017 - 02/2004)
4.	Plun-Favreau, H: 3 articles (06/2012 - 03/2009)
5.	Wood, N W: 3 articles (06/2012 - 03/2009)
6.	Jin, Yao: 2 articles (01/2022 - 12/2020)
7.	Meng, Hao: 2 articles (01/2022 - 12/2020)
8.	Su, Jing: 2 articles (01/2022 - 12/2020)
9.	Winblad, Bengt: 2 articles (07/2019 - 12/2015)
10.	Biagioni, Francesca: 2 articles (01/2018 - 01/2018)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 11/10/2006 - "Our study suggests that the direct cleavage of mitochondrial APP by HtrA2 may prevent mitochondrial dysfunction caused by accumulation of APP and that the regulation of HtrA2 protease activity may be a therapeutic target in AD." 06/28/2012 - "Loss of the mitochondrial protease HtrA2 (Omi) in mice leads to mitochondrial dysfunction, neurodegeneration and premature death, but the mechanism underlying this pathology remains unclear. " 03/01/2009 - "Mitochondrial dysfunction caused by loss of the serine protease HtrA2 leads to a progressive movement disorder in mice and has been linked to parkinsonian neurodegeneration in humans. " 11/01/2007 - "In mice, targeted deletion of the serine protease HtrA2 (also known as Omi) causes mitochondrial dysfunction leading to a neurodegenerative disorder with parkinsonian features. " 01/01/2011 - "Heterozygous loss-of-function mutation of the human gene for the mitochondrial protease HtrA2 has been associated with increased risk to develop mitochondrial dysfunction, a process known to contribute to neurodegenerative disorders such as Huntington's disease (HD) and Parkinson's disease (PD). "
2.	Prostatic Neoplasms (Prostate Cancer) 03/01/2015 - "The serine protease Omi/HtrA2 modulates Zn(2+) -dependent apoptosis in prostate cancer cells and represents a new target for treatment of CRPC. " 03/01/2015 - "The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2." 01/01/2005 - "To study the expression and significance of the serine protease Omi/HtrA2 in prostate cancer and benign prostatic hyperplasia. "
3.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/01/2005 - "To study the expression and significance of the serine protease Omi/HtrA2 in prostate cancer and benign prostatic hyperplasia. "
4.	Melanoma (Melanoma, Malignant) 09/01/2006 - "Studies of the melanoma-associated IAP (ML-IAP) Livin, using recombinant molecules, have implicated both caspases 3/7 and the serine protease Omi/HtrA2 in its proteolytic cleavage. "
5.	Experimental Arthritis 01/01/2021 - "The present study aims to investigate the role of HtrA serine peptidase 2 (HtrA2) in the collagen-induced arthritis. "

Related Drugs and Biologics

1.	Caspases
2.	Proteins (Proteins, Gene)
3.	Phosphotransferases (Kinase)
4.	Peptides (Polypeptides)
5.	Heat-Shock Proteins (Heat-Shock Protein)
6.	Proteasome Inhibitors
7.	Inflammasomes
8.	Mediator Complex Subunit 1
9.	Sirtuin 3
10.	Sirtuin 1