Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia.

Abstract

To study the expression and significance of the serine protease Omi/HtrA2 in prostate cancer and benign prostatic hyperplasia. The expression of Omi/HtrA2 was assayed by means of immunohistochemical technique in 41 prostate cancer (Cap), 20 benign prostatic hyperplasia (BPH) and 10 normal prostate (NP) specimens. Omi/HtrA2 expression was positive in 30 (73.17%) prostate cancer specimens, and the positive rate of Omi/HtrA2 was lower in well differentiated than in poorly and moderately differentiated groups (P < 0.05). By contrast, the cells in normal prostate and benign prostatic hyperplasia groups showed no or weak expression of Omi/HtrA2. Prostate cancer cells in vivo may need Omi/HtrA2 expression for apoptosis, and that Omi/HtrA2 expression might be involved in prostate cancer development.

• Authors: Xiaoyong Hu, Xiaochun Chen, Hao Ping, Zhaohui Chen, Fuqing Zeng, Gongcheng Lu
• Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (J Huazhong Univ Sci Technolog Med Sci) Vol. 25 Issue 6 Pg. 671-3 ( 2005) ISSN: 1672-0733 [Print] China
• PMID: 16696322 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Mitochondrial Proteins
• Serine Endopeptidases
• HTRA2 protein, human
• High-Temperature Requirement A Serine Peptidase 2

Topics

• Adult
• Apoptosis (physiology)
• Cells, Cultured
• High-Temperature Requirement A Serine Peptidase 2
• Humans
• Immunohistochemistry
• Male
• Mitochondrial Proteins (analysis, biosynthesis)
• Prostatic Hyperplasia (metabolism, pathology)
• Prostatic Neoplasms (metabolism, pathology)
• Serine Endopeptidases (analysis, biosynthesis)
• Tumor Cells, Cultured