NADPH Oxidase 1

An NADPH oxidase that functions as a voltage-gated proton channel expressed by PHAGOCYTES, especially in the colon. It regulates intracellular pH, generates SUPEROXIDES upon activation by PHAGOCYTOSIS, and may play a role in INNATE IMMUNITY.

Also Known As:

Networked: 77 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Doroshow, James H: 6 articles (11/2021 - 04/2013)
2.	Lu, Jiamo: 5 articles (11/2021 - 04/2013)
3.	Juhasz, Agnes: 4 articles (01/2020 - 04/2013)
4.	Antony, Smitha: 3 articles (01/2020 - 06/2017)
5.	Jiang, Guojian: 3 articles (01/2020 - 06/2017)
6.	Liu, Han: 3 articles (01/2020 - 06/2017)
7.	Meitzler, Jennifer L: 3 articles (01/2020 - 06/2017)
8.	Roy, Krishnendu: 3 articles (01/2020 - 06/2017)
9.	Wu, Yongzhong: 3 articles (01/2020 - 06/2017)
10.	Lambeth, J David: 3 articles (01/2016 - 02/2005)

Related Diseases

1.	Inflammation (Inflammations) 10/07/2021 - "NADPH oxidase 1 (Nox1) overexpression reversed the improving effects of Ala on renal function, inflammation and apoptosis of I/R rats. " 01/01/2016 - "Role of NADPH oxidase 1 (NOX1) in gut inflammation." 01/01/2019 - "NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice." 01/01/2016 - "In contrast, NADPH oxidase 1 (Nox1) was reported to decrease inflammation in mice within 7 days post-influenza A virus infection. " 01/01/2023 - "In this study, we analyzed the potential regulatory role of nuclear factor erythroid-2-related factor 2 (Nrf2) on NADPH oxidase 1 (NOX1) in tumor necrosis factor-α (TNF-α)-induced inflammation and oxidative stress in human type II alveolar epithelial cells. "
2.	Colitis 03/01/2014 - "To test whether NADPH oxidase 1 (Nox1) contributes to colitis, we generated B6 triple-KO (TKO) mice to study their phenotype. " 01/01/2014 - "Tumor necrosis factor-α-induced colitis increases NADPH oxidase 1 expression, oxidative stress, and neutrophil recruitment in the colon: preventive effect of apocynin."
3.	Hypoxia (Hypoxemia) 07/01/2013 - "Cell line studies have previously demonstrated that hypoxia-reoxygenation (H/R) leads to the production of NADPH oxidase 1 and 2 (NOX1 and NOX2)-dependent reactive oxygen species (ROS) required for the activation of c-Src and NF-κB. " 01/01/2019 - "Our major goals were to determine if reactive oxygen species (ROS) modulate SNAT1 expression in PAECs from newborn piglets and to evaluate the role of NADPH oxidase 1 (NOX1) and uncoupled endothelial NO synthase, enzymatic sources of ROS, in hypoxia-induced increases in SNAT1 expression. "
4.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/01/2023 - "Setanaxib, a first-in-class selective NADPH oxidase 1/4 inhibitor for primary biliary cholangitis: A randomized, placebo-controlled, phase 2 trial."
5.	Neoplasms (Cancer) 01/01/2020 - "NADPH oxidase 1 is highly expressed in human large and small bowel cancers." 01/01/2018 - "In particular, this analysis evidenced strongly up-modulated NADPH oxidase 1 (NOX1) transcript levels in tumor cells lacking LKB1. " 11/01/2011 - "A catalytic subunit of NADPH oxidase 1 (Nox1) is implicated to be involved in neoplastic progression in human epithelial cancers. " 02/07/2011 - "Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism." 01/01/2019 - "NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice."

Related Drugs and Biologics

1.	Enzymes
2.	Dextran Sulfate
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	setanaxib
6.	NADPH Oxidases (NAD(P)H oxidase)
7.	Proteins (Proteins, Gene)
8.	Messenger RNA (mRNA)
9.	Oxidoreductases (Dehydrogenase)
10.	Matrix Metalloproteinase 2 (Gelatinase A)

Related Therapies and Procedures

1.	Therapeutics
2.	Intraperitoneal Injections
3.	Hepatectomy