Notch4 Receptor

A notch receptor and proto-oncogene protein characterized by a large extracellular domain that consists of 29 EPIDERMAL GROWTH FACTOR - like repeat sequences (EGF repeats) and five ANKYRIN REPEATS. It functions as a receptor for SERRATE-JAGGED PROTEINS and Delta1 (DLK1) protein to control cell fate determination.

Also Known As:

Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bakhshpour, Monireh: 2 articles (01/2022 - 11/2019)
2.	Denizli, Adil: 2 articles (01/2022 - 11/2019)
3.	Piskin, Ayse Kevser: 2 articles (01/2022 - 11/2019)
4.	Yavuz, Handan: 2 articles (01/2022 - 11/2019)
5.	Clarke, Robert B: 2 articles (04/2019 - 01/2010)
6.	Arbag, Sena: 1 article (11/2020)
7.	Baris, Safa: 1 article (11/2020)
8.	Benamar, Mehdi: 1 article (11/2020)
9.	Charbonnier, Louis-Marie: 1 article (11/2020)
10.	Chatila, Talal A: 1 article (11/2020)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/01/2019 - "The human metastatic breast cancer cells, MDA MB 231 cells, are used here as a model due to the overexpression of notch-4 receptor on their membranes. " 01/15/2010 - "Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor." 01/01/2020 - "Rationale: NOTCH4 receptor has been implicated in triple-negative breast cancer (TNBC) development and breast cancer stem cell (BCSC) regulation. " 01/01/2020 - "In cells immune-stained for endogenous Notch4, protein was detected in the nucleolus and nucleoplasm, which was also confirmed by the co-localization of NIC4-GFP with RFP-tagged nucleolar proteins in breast cancer cells or the unrelated HEK cell line. " 06/14/2011 - "Real-time PCR and Western blot analysis were performed to detect Notch-1, Notch-2, Notch-3 and Notch-4 receptor expression in breast cancer cells when PEA3 was knocked down by siRNA. "
2.	Neoplasms (Cancer) 01/01/2022 - "Preparation of Notch-4 Receptor Containing Quartz Crystal Microbalance Biosensor for MDA MB 231 Cancer Cell Detection." 11/01/2019 - "These results indicate that, the notch-4 receptor antibody PHEMA nanoparticle QCM biosensor is highly selective and efficient system that may be used for cancer cell detection." 11/01/2019 - "Quartz crystal microbalance biosensor for label-free MDA MB 231 cancer cell detection via notch-4 receptor." 01/01/2019 - "In search of a critical diagnostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma, Notch4 receptor, one of the key regulatory molecules of the Notch signaling family has been aberrantly activated in the progression of several types of tumors. " 04/11/2019 - "We demonstrated that FKBPL overexpression or treatment with FKBPL-based therapeutics (AD-01, pre-clinical peptide /ALM201, clinical peptide) inhibit i) CSCs in both ER+ and ER- breast cancer, ii) cancer metastasis in a triple negative breast cancer metastasis model and iii) endocrine therapy resistant CSCs in ER+ breast cancer, via modulation of the DLL4 and Notch4 protein and/or mRNA expression. "
3.	Triple Negative Breast Neoplasms 01/01/2020 - "Rationale: NOTCH4 receptor has been implicated in triple-negative breast cancer (TNBC) development and breast cancer stem cell (BCSC) regulation. " 04/11/2019 - "We demonstrated that FKBPL overexpression or treatment with FKBPL-based therapeutics (AD-01, pre-clinical peptide /ALM201, clinical peptide) inhibit i) CSCs in both ER+ and ER- breast cancer, ii) cancer metastasis in a triple negative breast cancer metastasis model and iii) endocrine therapy resistant CSCs in ER+ breast cancer, via modulation of the DLL4 and Notch4 protein and/or mRNA expression. "
4.	Verrucous Carcinoma 01/01/2019 - "In search of a critical diagnostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma, Notch4 receptor, one of the key regulatory molecules of the Notch signaling family has been aberrantly activated in the progression of several types of tumors. "
5.	Endometrial Neoplasms (Endometrial Cancer) 01/01/2014 - "The level of NOTCH4 receptor was 1.7 times lower in stage I endometrial cancer as compared with the healthy tissue of the same patients (P=0.04). "

Related Drugs and Biologics

1.	Quartz
2.	Particulate Matter
3.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
4.	Small Interfering RNA (siRNA)
5.	Messenger RNA (mRNA)
6.	Polyhydroxyethyl Methacrylate (PHEMA)
7.	Peptides (Polypeptides)
8.	Nuclear Proteins (Protein, Nuclear)
9.	Environmental Pollutants (Pollutants, Environmental)
10.	Allergens

Related Therapies and Procedures

1.	Therapeutics