Kisspeptin-1 Receptors

G protein coupled receptors for the C-terminally amidated peptide of KISSPEPTIN-1. KISS1R plays an essential role in sexual development during puberty through its regulation of GONADOTROPIN-released hormones.

Also Known As:

Receptors, Kisspeptin-1; G Protein-Coupled Receptor 54; KISS1 Receptor; KISS1R; Kisspeptin-1 Receptor; G Protein Coupled Receptor 54; Kisspeptin 1 Receptor; Receptor, KISS1; Receptor, Kisspeptin-1; Receptors, Kisspeptin 1

Networked: 191 relevant articles (1 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Kisspeptin-1 Receptors: 191
        human KISS1R protein
        mouse Kiss1r protein
        rat Kiss1r protein
        zebrafish kiss1ra protein
      - Peptide Receptors: 1159
        Kisspeptin-1 Receptors: 191
        human KISS1R protein
        mouse Kiss1r protein
        rat Kiss1r protein
        zebrafish kiss1ra protein

Experts

1.	Babwah, Andy V: 16 articles (01/2022 - 01/2011)
2.	Bhattacharya, Moshmi: 13 articles (01/2022 - 01/2011)
3.	Tena-Sempere, Manuel: 7 articles (01/2019 - 07/2009)
4.	Dragan, Magdalena: 6 articles (01/2022 - 06/2013)
5.	Kauffman, Alexander S: 6 articles (01/2022 - 07/2014)
6.	Kaiser, Ursula B: 6 articles (01/2019 - 04/2011)
7.	Brackstone, Muriel: 5 articles (01/2020 - 01/2017)
8.	Koutsilieris, Michael: 5 articles (01/2020 - 03/2014)
9.	Smith, Jeremy T: 5 articles (01/2020 - 03/2014)
10.	Tolson, Kristen P: 5 articles (01/2020 - 07/2014)

Related Diseases

1.	Pyometra 11/01/2021 - "The findings reveal that there is a gene correlation between kisspeptin/Kiss1r and angiogenic and immune mediators in the uterus of the domestic cat, which is modulated by the estrous cycle, and that pyometra affects the expression of these mediators. " 11/01/2021 - "Because there is no in vivo research on the functional relationship between these factors in the reproductive system, especially in domestic cats, we evaluated the expression profile of kisspeptin/Kiss1r and angiogenic and immunological mediators in the genital tract of cyclic cats and of those with pyometra. " 11/01/2021 - "Cats with pyometra showed greater immunostaining of Kiss1 and Kiss1r on the endometrial surface and reduced immunostaining of Kiss1 in deep glands, whereas there was a significant reduction in Vegf, Pigf, Mif, and Il6 mRNA, and an increase in Tnf mRNA. "
2.	Breast Neoplasms (Breast Cancer) 11/01/2022 - "The goal of this study was to evaluate the expression of KISS1 and KISS1R in breast carcinomas from African American (AA) women and correlate their association with clinicopathological features, including breast cancer subtypes, and outcomes. " 06/01/2015 - "Immunohistochemical study of KiSS1 and KiSS1R expression in human primary breast cancer: Association with breast cancer receptor status, proliferation markers and clinicopathological features." 09/26/2013 - "On the other hand, recent studies indicate that KP/KISS1R pathway plays detrimental roles in breast cancer. " 11/01/2022 - "Inverse Correlation of KISS1 and KISS1R Expression in Triple-negative Breast Carcinomas from African American Women." 03/01/2022 - "The role of KP/KISS1R signaling in breast cancer remains controversial. "
3.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "Overall, this study establishes KISS1R as a novel regulator of TNBC metabolism and metastasis, suggesting that targeting KISS1R could have therapeutic potential in the treatment of TNBC." 12/01/2015 - "In this study, we investigated KISS1 and KISS1R expression in colorectal liver metastasis (CRLM), and analyzed their correlation with patients' clinicopathological variables, including prognosis. " 06/01/2021 - "KiSS‑1 metastasis suppressor (KISS1)/KISS1 receptor (KISS1R) serves an important role in regulating adolescent sexual maturity and reproductive system development in mammals; however, the mechanism underlying KISS1/KISS1R in reproductive dysfunction in male patients with diabetes is not completely understood. " 03/01/2016 - "Taken together, our findings suggest that targeting the KISS1R signaling axis might be a promising strategy to inhibit invasiveness and metastasis. " 07/01/2015 - "No KISS1R expression was detected in normal or malignant tissues or in liver metastases. "
4.	Neoplasms (Cancer) 06/01/2015 - "Recent studies have raised doubts about the protective role of KiSS1/KiSS1R in breast malignancy progression. " 11/01/2022 - "Higher KISS1R expression was marginally negatively correlated with tumor size (p=0.077), and positively correlated with lymph-node positivity (p=0.056), and disease-free survival (p=0.092). " 11/01/2022 - "However, KISS1R expression was higher in non-TNBC tumors compared to other subtypes (p<0.001). " 01/01/2020 - "A higher expression of KISS1 and KISS1R was shown in patients with localized tumors (Stage ≤IIb) compared to patients with advanced (Stage ≥III) tumor. " 01/01/2019 - "In many human tumors, KISS1 functions as a metastasis-suppressor gene and KISS1/KISS1R signaling has antimetastatic and tumor-suppressor roles. "
5.	Precocious Puberty 01/01/2023 - "Furthermore, a few gain-of-function variants of KISS1R, PROKR2, and LHCGR have been implicated in precocious puberty. " 01/01/2021 - "Some mutations in human KISS1R gene make the receptor prematurely activated and result in the development of central precocious puberty. " 01/01/2017 - "Genetic Variations of the KISS1R Gene in Korean Girls with Central Precocious Puberty." 01/01/2014 - "Mutational analysis of KISS1 and KISS1R in idiopathic central precocious puberty." 09/22/2011 - "LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Interleukin-6 (Interleukin 6)
4.	Kisspeptins
5.	Kisspeptin-1 Receptors
6.	Gonadotropin-Releasing Hormone (GnRH)
7.	Hormones (Hormone)
8.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)
9.	Proteins (Proteins, Gene)
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Therapeutics
2.	Electroacupuncture
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Drug Therapy (Chemotherapy)