Aldo-Keto Reductase Family 1 member B10

Aldo-keto reductase that functions as an all-trans-retinaldehyde reductase. It also reduces aromatic and aliphatic ALDEHYDES.

Also Known As:

AKR1B10 Protein; Aldose Reductase-Like Protein; Aldose Reductase-Related Protein; Aldo Keto Reductase Family 1 member B10; Aldose Reductase Like Protein; Aldose Reductase Related Protein

Networked: 50 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - Carbohydrate Dehydrogenases
        Sugar Alcohol Dehydrogenases
        Aldo-Keto Reductases: 299
        Aldo-Keto Reductase Family 1 member B10: 50
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        Aldo-Keto Reductases: 299
        Aldo-Keto Reductase Family 1 member B10: 50

Experts

1.	Cao, Deliang: 6 articles (01/2019 - 05/2009)
2.	Genda, Takuya: 4 articles (03/2017 - 10/2012)
3.	Hirano, Katsuharu: 4 articles (03/2017 - 10/2012)
4.	Ichida, Takafumi: 4 articles (03/2017 - 10/2012)
5.	Iijima, Katsuyori: 4 articles (03/2017 - 10/2012)
6.	Kanemitsu, Yoshio: 4 articles (03/2017 - 10/2012)
7.	Kikuchi, Tetsu: 4 articles (03/2017 - 10/2012)
8.	Narita, Yutaka: 4 articles (03/2017 - 10/2012)
9.	Sato, Shunsuke: 4 articles (03/2017 - 10/2012)
10.	Tsuzura, Hironori: 4 articles (03/2017 - 10/2012)

Related Diseases

1.	Neoplasms (Cancer) 08/15/2011 - "In the present study, we found that AKR1B10 protein is secreted from normal intestinal epithelium and cultured cancer cells, as detected by a newly developed sandwich ELISA and Western blotting. " 01/01/2024 - "Aldo-keto reductase family 1 member B10 (AKR1B10) is expressed in various types of cancer. " 12/01/2018 - "Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with several cancer types. " 01/01/2016 - "Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment." 01/01/2017 - "To clarify the relationship between aldo-keto reductase family 1 member B10 (AKR1B10) expression and early hepatocellular carcinoma (HCC) recurrence, this study detected AKR1B10 expression in tumor and adjacent non-tumor tissues from 110 patients with hepatitis B virus (HBV)-related HCC underwent liver resection and analyzed its correlations with clinicopathological characteristics and prognosis of these patients. "
2.	Hepatocellular Carcinoma (Hepatoma) 11/01/2014 - "The goal of this study was to evaluate the prognostic significance of AKR1B10 protein expression in patients with hepatocellular carcinoma after surgery. " 01/01/2022 - "To evaluate the clinical value of Aldo-keto reductase family 1 member B10 (AKR1B10) in the diagnosis and prognosis of hepatocellular carcinoma (HCC). " 10/20/2020 - "Results: AKR1B10 expression level in hepatoma cells was significantly increased compared to normal liver cells, and the relative expression level of AKR1B10 protein in HepG2 cells was 6.71 ± 1.11 (P = 0.012). " 10/20/2020 - "Objective: Aldo-keto reductase family 1 member B10 (AKR1B10) pathogenesis, early diagnosis and prognosis are closely related with hepatoma. " 12/01/2018 - "Identification of a role for serum aldo-keto reductase family 1 member B10 in early detection of hepatocellular carcinoma."
3.	Breast Neoplasms (Breast Cancer) 05/16/2017 - "Aldo-keto reductase family 1, member B10 (AKR1B10), is known to be significantly induced in the cells of various cancers such as breast cancer. " 08/21/2021 - "Aberrant expression of Aldo-Keto reductase family 1 member B10 (AKR1B10) was associated with tumor size and metastasis of breast cancer in our published preliminary studies. "
4.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 09/01/2021 - "The aim of the present study was to investigate the expression of aldo-keto reductase family 1 member B10 (AKR1B10) in benign prostatic hyperplasia (BPH) and its related mechanism. "
5.	Neoplasm Metastasis (Metastasis) 08/21/2021 - "Aberrant expression of Aldo-Keto reductase family 1 member B10 (AKR1B10) was associated with tumor size and metastasis of breast cancer in our published preliminary studies. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Biomarkers (Surrogate Marker)
3.	Methylnitrosourea (N-Methyl-N-nitrosourea)
4.	Amino Acids
5.	Oxidoreductases (Dehydrogenase)
6.	Enzymes
7.	Xenobiotics
8.	Aldehyde Reductase (Aldose Reductase)
9.	Aldo-Keto Reductases
10.	Retinoid X Receptors (Retinoid X Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Hepatectomy