High-Temperature Requirement A Serine Peptidase 1

A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).

Also Known As:

Networked: 63 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Baldi, Alfonso: 10 articles (01/2016 - 09/2002)
2.	Nozaki, Hiroaki: 6 articles (11/2021 - 01/2012)
3.	Chien, Jeremy: 6 articles (05/2021 - 07/2006)
4.	Onodera, Osamu: 5 articles (11/2021 - 01/2017)
5.	Oka, Chio: 5 articles (01/2018 - 09/2005)
6.	De Luca, Antonio: 5 articles (04/2014 - 09/2002)
7.	Shridhar, Viji: 5 articles (02/2011 - 07/2006)
8.	Ehrmann, Michael: 4 articles (01/2018 - 07/2006)
9.	Ando, Shoichiro: 3 articles (11/2021 - 01/2019)
10.	Kanazawa, Masato: 3 articles (11/2021 - 01/2019)

Related Diseases

1.	Macular Degeneration (Age-Related Maculopathy) 06/01/2009 - "High-temperature requirement serine protease (HTRA1) was identified as a candidate age-related macular degeneration gene in multiple genetic studies in humans. " 01/01/2021 - "Genome-wide association studies have identified the chromosome 10q26 (Chr10) locus, which contains the age-related maculopathy susceptibility 2 (ARMS2) and high temperature requirement A serine peptidase 1 (HTRA1) genes, as the strongest genetic risk factor for age-related macular degeneration (AMD) [L.G. " 01/01/2021 - "Additionally, genome-wide association studies have identified several genetic variants in the age-related maculopathy susceptibility 2/high-temperature requirement A serine peptidase 1 (ARMS2-HTRA1) locus associated with the progression of late-stage AMD, especially the wet subtype. " 01/01/2019 - "Genetic variants of high-temperature requirement A serine peptidase 1 (HTRA1) and age-related maculopathy susceptibility 2 (ARMS2) are associated with age-related macular degeneration (AMD). " 01/01/2017 - "High-temperature requirement A serine peptidase 1 (HTRA1) and age-related maculopathy susceptibility 2 (ARMS2) are two genes that are strongly associated with AMD. "
2.	Polypoidal Choroidal Vasculopathy 01/01/2012 - "Multiple genetic studies have suggested that high-temperature requirement serine protease (HTRA1) is associated with polypoidal choroidal vasculopathy (PCV). " 08/30/2011 - "Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice."
3.	Choroidal Neovascularization 01/01/2017 - "The purpose of this study was to evaluate the expression of high-temperature requirement A serine peptidase 1 (HTRA1), TGF-β1, bone morphogenetic protein 4 (BMP4), growth differentiation factor 6 (GDF6), and VEGFA proteins in the aqueous humor of patients with naïve choroidal neovascularization (nCNV) secondary to AMD. "
4.	Endometrial Neoplasms (Endometrial Cancer) 02/01/2011 - "The purpose of this study was to determine if loss of serine protease HtrA1 in endometrial cancer will promote the invasive potential of EC cell lines. "
5.	Malignant Mesothelioma 08/01/2008 - "The objective of our study was to analyze the potential prognostic value of the expression of the serine protease HtrA1 and of EGFR in 70 malignant mesotheliomas. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Growth Differentiation Factor 6
3.	Bone Morphogenetic Protein 4
4.	Complement Factor H (Factor H)
5.	Collagen Type VIII
6.	Complement Factor B (Factor B)
7.	Complement C3 (C3 Complement)
8.	Complement C2 (Complement Component 2)
9.	Antigens
10.	Amyloid (Amyloid Fibrils)