TRPC6 Cation Channel

A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.

Also Known As:

Networked: 509 relevant articles (36 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dietrich, Alexander: 17 articles (01/2021 - 12/2006)
2.	Birnbaumer, Lutz: 14 articles (01/2020 - 01/2012)
3.	Gudermann, Thomas: 11 articles (01/2022 - 12/2006)
4.	Tepel, Martin: 11 articles (01/2022 - 04/2007)
5.	Reiser, Jochen: 11 articles (11/2016 - 07/2005)
6.	Nishida, Motohiro: 10 articles (01/2021 - 07/2006)
7.	Dryer, Stuart E: 9 articles (01/2022 - 10/2010)
8.	Wang, Jian: 9 articles (12/2021 - 01/2010)
9.	Nijenhuis, Tom: 8 articles (11/2021 - 10/2011)
10.	van der Vlag, Johan: 8 articles (11/2021 - 10/2011)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2017 - "Therefore, we conclude that TRPC6 is an important determinant for TGF-β1-induced myofibroblast differentiation during fibrosis and specific channel inhibitors might be beneficial in a future treatment of PF." 01/01/2019 - "These results provide in vivo evidence of therapeutic efficacy for a selective pharmacological TRPC6 inhibitor with oral bioavailability and suitable pharmacokinetics to ameliorate cardiac and renal stress-induced disease with fibrosis." 01/01/2019 - "In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease." 12/12/2017 - "Trpc6 deletion also ameliorated left ventricular dilation, improved cardiac function, and tended to reduce fibrosis. " 01/01/2017 - "The magnitude of protection against obstruction-induced fibrosis in Trpc3 and Trpc6 double knockout mice was not different from that in Trpc6 knockout mice. "
2.	Hypoxia (Hypoxemia) 01/01/2021 - "Further study showed that the TRPC6 expression levels were significantly increased by hypoxia, which were inhibited by the HIF1α inhibitor in podocytes. " 01/01/2018 - "Our previous study showed that transient receptor potential canonical channel-6 (TRPC6), a major Ca2+ influx pathway in podocytes, was activated by hypoxia. " 02/01/2016 - "Results from the present study suggest that TRPC6 expression is increased during chronic hypoxia, which contributes to Ca2+ entry into the cell, thus promoting proliferation and migration of PVSMCs." 08/01/2015 - "The aim of the present study was to understand the role of TRPC6 signaling in regulating the molecular mechanism of HSCs in response to hypoxia. " 12/15/2013 - "Studies in a TRPC6-deficient mouse model revealed an essential function of TRPC6 in acute but not in chronic hypoxia. "
3.	Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2022 - "Klotho Ameliorates Podocyte Injury through Targeting TRPC6 Channel in Diabetic Nephropathy." 11/18/2022 - "TRPC6 knockout has proven to be less effective at reducing diabetic nephropathy in mouse and rat models. " 01/01/2020 - "Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement." 12/01/2019 - "While there is strong evidence that glomerular TRPC6 channels are dysregulated in diabetic nephropathy (DN), there is no consensus as to whether deletion or inactivation of TRPC6 is protective in animal models of DN. " 01/01/2019 - "The underlining goal of this review is to offer a concise, detailed look into current knowledge surrounding transient receptor potential canonical channel 6 (TRPC6) in the progression of diabetic kidney disease (DKD). "
4.	Reperfusion Injury 11/10/2023 - "To investigate the mechanism by which NF-κB p65 activates miR-150 to suppress TRPC6 expression and promote renal ischemia-reperfusion injury. " 01/01/2019 - "The greater effect of high-intensity interval training versus moderate-intensity continuous training on cardioprotection against ischemia-reperfusion injury through Klotho levels and attenuate of myocardial TRPC6 expression." 07/04/2018 - "TRPC6 also modulates the sensitivity of immune cells to apoptosis and influences tissue susceptibility to ischemia-reperfusion injury and excitotoxicity. " 02/25/2016 - "TRPC6 May Protect Renal Ischemia-Reperfusion Injury Through Inhibiting Necroptosis of Renal Tubular Epithelial Cells." 03/01/2022 - "TRPC6 ameliorates renal ischemic reperfusion injury by inducing Zn2+ influx and activating autophagy to resist necrosis."
5.	Kidney Diseases (Kidney Disease) 04/14/2023 - "Previous studies demonstrated that TRPC6 channels play a pivotal role in podocyte function and their dysregulation is associated with development of different kidney diseases including nephropathy. " 11/18/2022 - "Here, we will describe TRPC6 channels and their roles in signal transduction, with an emphasis on renal cells, and the studies implicating TRPC6 channels in the progression of inherited and acquired kidney diseases. " 01/01/2020 - "Many studies have recently shown that transient receptor potential canonical channel 6 (TRPC6) in podocyte plays a critical role in the development and progression of proteinuric kidney disease by regulating its actin cytoskeleton rearrangement. " 11/01/2016 - "This review highlights how recent studies analyzing function and expression of TRPC6 channels in the kidney and their response to ROS improve our mechanistic understanding of oxidative stress-related kidney diseases. " 11/18/2022 - "The Effects of TRPC6 Knockout in Animal Models of Kidney Disease."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Calpain
3.	TRPC6 Cation Channel
4.	Tacrolimus (Prograf)
5.	Blood Glucose (Blood Sugar)
6.	Messenger RNA (mRNA)
7.	Cations
8.	Monocrotaline
9.	SH045
10.	Small Interfering RNA (siRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Noninvasive Ventilation
4.	Ligation
5.	Glycemic Control