Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS.
Also Known As:
Receptors, Enterotoxin; Enterotoxin Receptor; Enterotoxin-Guanylin Receptor; Enterotoxin-Guanylin Receptors; GC-C Receptor; GC-C Receptors; Guanyl Cyclase-C Receptor; Guanyl Cyclase-C Receptors; Guanylin-Uroguanylin Receptor; Guanylin-Uroguanylin Receptors; Guanylyl Cyclase C; Heat-Stable Enterotoxin Receptor; Heat-Stable Enterotoxin Receptors; Receptor, Enterotoxin; Receptor, Guanyl Cyclase-C; Receptors, Guanyl Cyclase-C; Cyclase C, Guanylyl; Cyclase-C Receptors, Guanyl; Enterotoxin Guanylin Receptor; Enterotoxin Guanylin Receptors; Enterotoxin Receptor, Heat-Stable; Enterotoxin Receptors, Heat-Stable; GC C Receptor; GC C Receptors; Guanyl Cyclase C Receptor; Guanyl Cyclase C Receptors; Guanylin Uroguanylin Receptor; Guanylin Uroguanylin Receptors; Heat Stable Enterotoxin Receptor; Heat Stable Enterotoxin Receptors; Receptor, Enterotoxin-Guanylin; Receptor, GC-C; Receptor, Guanyl Cyclase C; Receptor, Guanylin-Uroguanylin; Receptor, Heat-Stable Enterotoxin; Receptors, Enterotoxin-Guanylin; Receptors, GC-C; Receptors, Guanyl Cyclase C; Receptors, Guanylin-Uroguanylin; Receptors, Heat-Stable Enterotoxin