Member 11 Subfamily B ATP Binding Cassette Transporter

ATP-binding cassette, subfamily B, protein (P-glycoproteins) that functions in the ATP-dependent secretion of BILE SALTS into the BILE CANALICULI of HEPATOCYTES. Mutations in the ABCB11 gene are associated with progressive familial intrahepatic cholestasis 2 (see CHOLESTASIS, INTRAHEPATIC).

Also Known As:

Networked: 278 relevant articles (5 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Knisely, A S: 17 articles (01/2018 - 03/2000)
2.	Stieger, Bruno: 16 articles (01/2019 - 11/2002)
3.	Hayashi, Hisamitsu: 12 articles (06/2020 - 04/2005)
4.	Häussinger, Dieter: 11 articles (12/2018 - 05/2003)
5.	Kubitz, Ralf: 11 articles (12/2017 - 05/2003)
6.	Brouwer, Kim L R: 10 articles (10/2019 - 05/2004)
7.	Thompson, Richard J: 9 articles (01/2022 - 08/2006)
8.	Jacquemin, Emmanuel: 9 articles (01/2021 - 01/2006)
9.	Keitel, Verena: 9 articles (02/2019 - 05/2005)
10.	Crocenzi, Fernando A: 8 articles (02/2018 - 02/2005)

Related Diseases

1.	Cholestasis 01/01/2022 - "Histopathological assessment revealed marked cholestasis in the hepatocytes, Kupffer cells, and bile canaliculi, as well as a well-preserved intralobular bile duct arrangement and strongly expressed bile salt export pump at the canalicular membrane. " 01/01/2020 - "Bile salt export pump (BSEP) KO mice are metabolically preconditioned with a hydrophilic BA composition protecting them from cholestasis. " 06/02/2018 - "Related literature from PubMed, CNKI and Wangfang databases was reviewed to date (up to August 2017) with 'ABCB11 gene' or 'bile salt export pump', 'cholestasis' and 'child' as key words. " 01/01/2018 - "Progressive familial cholestasis type 2 is caused by a genetically determined absence or reduction in the activity of the bile salt export pump (BSEP). " 01/01/2017 - "Inhibition of the bile salt export pump by drugs is a well-established cause of drug-induced cholestasis. "
2.	Liver Diseases (Liver Disease) 02/28/2022 - "Bile salt export pump immunohistochemical staining showed normal canalicular expression in two patients with PFIC type 1, focal loss in two patients with PFIC type 2, and total loss in three patients with PFIC type 2. LT is currently the only effective treatment for PFIC-associated end-stage liver diseases. " 01/01/2018 - "Genetic defects causing dysfunction in bile salt export pump (BSEP/ABCB11) lead to liver diseases. " 01/01/2011 - "Genetic variants of the bile salt export pump: inducers and modifiers of liver diseases." 05/01/2010 - "The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease." 04/01/2008 - "Patients with severe bile salt export pump (BSEP) deficiency present as infants with progressive cholestatic liver disease. "
3.	Intrahepatic Cholestasis 02/01/2010 - "Histological examination may be helpful in differentiating familial intrahepatic cholestasis type 1 from bile salt export pump-related disease." 11/08/2021 - "Further mechanistic studies demonstrated that Sema7aR145W mutation reduced the expression of canalicular membrane BA transporters, bile salt export pump (Bsep), and multidrug resistance-associated protein-2 (Mrp2), causing intrahepatic cholestasis in mice. " 06/01/2020 - "Bile salt export pump (BSEP) deficiency manifests a form of progressive intrahepatic cholestasis. " 06/01/2019 - "ABCB11 encodes the bile salt export pump and this gene is mutated in several forms of intrahepatic cholestasis. " 06/01/2013 - "Liver biopsy demonstrated deficiency of canalicular GGT and bile salt export pump expression, which suggested "benign" recurrent intrahepatic cholestasis. "
4.	Fatty Liver 01/01/2020 - "Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet." 01/27/2022 - "LT in PFIC has its own unique issues like high rates of intractable diarrhoea, growth failure; steatohepatitis and graft failure in PFIC1 and antibody-mediated bile salt export pump deficiency in PFIC2. " 04/01/2011 - "In the present issue of Clinical Science, Iwata and co-workers report an association between a variant of a gene regulating bile acid levels, ABCB11 1331T>C (where ABCB11 encodes ATP-binding cassette, subfamily B, member 11), and the progression to cirrhosis in patients with HCV, but not in fatty liver patients. "
5.	Alagille Syndrome (Alagille-Watson Syndrome) 01/01/2017 - "To evaluate the efficacy of nontransplant surgery for pediatric cholestasis, 58 clinically diagnosed children, including 20 with Alagille syndrome (ALGS), 16 with familial intrahepatic cholestasis-1 (FIC1), 18 with bile salt export pump (BSEP) disease, and 4 others with low γ-glutamyl transpeptidase disease (levels <100 U/L), were identified across 14 Childhood Liver Disease Research Network (ChiLDReN) centers. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Cholesterol
3.	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)
4.	Multidrug Resistance-Associated Protein 2
5.	Peptides (Polypeptides)
6.	Member 1 Subfamily B ATP Binding Cassette Transporter
7.	Anions
8.	Bile Acids and Salts (Bile Acids)
9.	Taurocholic Acid (Sodium Taurocholate)
10.	Organic Anion Transporters

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Hepatectomy
4.	Transplantation