T-Cell Intracellular Antigen-1

An RNA-binding protein characterized by three RNA RECOGNITION MOTIFS. It binds to AU RICH ELEMENTS in the 3'-untranslated regions of mRNA and regulates alternative pre-RNA splicing and mRNA translation; it may also function in APOPTOSIS. Mutations in the TIA-1 gene are associated with WELANDER DISTAL MYOPATHY.

Also Known As:

RNA-Binding Protein TIA-1; T-Cell-Restricted Intracellular Antigen-1; Intracellular Antigen-1, T-Cell; Intracellular Antigen-1, T-Cell-Restricted; RNA Binding Protein TIA 1; T Cell Intracellular Antigen 1; T Cell Restricted Intracellular Antigen 1; TIA-1, RNA-Binding Protein

Networked: 59 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chuang, Shih-Sung: 3 articles (04/2011 - 01/2002)
2.	Hasegawa, Yuichi: 3 articles (10/2005 - 11/2002)
3.	Kojima, Hiroshi: 3 articles (10/2005 - 11/2002)
4.	Mori, Naoyoshi: 3 articles (10/2005 - 11/2002)
5.	Nagasawa, Toshiro: 3 articles (10/2005 - 11/2002)
6.	Yamashita, Yoriko: 3 articles (10/2005 - 11/2002)
7.	Nakamura, S: 2 articles (04/2008 - 08/2001)
8.	Goto, Daisuke: 2 articles (07/2007 - 08/2006)
9.	Ito, Satoshi: 2 articles (07/2007 - 08/2006)
10.	Mamura, Mizuko: 2 articles (07/2007 - 08/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "In patients with high-grade and locally advanced PC, those with IL-30-/-tumors, showed distinct intra-tumoral cytotoxic granule-associated RNA binding protein (TIA-1)+CD4+Tlymphocyte infiltrate, rare Foxp3+Tregs and a lower biochemical recurrence rate compared to patients with IL-30+/+tumors in which IL-30 is expressed in both tumor cells and infiltrating leukocytes. " 11/01/2018 - "T-cell intracellular antigen-1 (TIA1) extensively involves in cancer progression, whereas its role and regulation mechanism in GC have not been revealed. " 03/01/2005 - "Immunohistologically, the tumor cells from the skin lesion expressed CD2, cytoplasmic CD3, CD56, and T-cell intracellular antigen-1 (TIA-1), but not surface CD3, CD19, and TdT. " 01/01/2017 - "T-cell intracellular antigen 1 (TIA1) is an important tumor suppressor involved in many aspects of carcinogenesis and cancer development. " 11/14/2023 - "The tumor cells expressed CD2, CD3, CD56, T-cell intracellular antigen-1, granzyme B, and Epstein-Barr virus-encoded RNAs (EBERs), with additional partial and weak CD20 and CD30 expression. "
2.	Lymphoma (Lymphomas) 01/01/2023 - "Furthermore, 4/11 abdominal lymphomas were immunopositive for T-cell intracellular antigen-1, suggesting cytotoxic T-cell lymphomas. " 11/01/2006 - "Resection of the mass showed a large cell lymphoma with immunohistochemical positivity for CD2, CD7, CD56, and T-cell intracellular antigen-1, compatible with natural killer cell origin. " 01/01/1999 - "Eighty cases of peripheral T-cell and NK-cell lymphomas, classified according to the REAL classification, were investigated for cytotoxic phenotype (by studying T-cell intracellular antigen-1 (TIA-1) expression immunohistochemically) and EBV association (by in situ hybridization for EBV-encoded small non-polyadenylated RNAs), and the results were correlated with the specific clinicopathological types and the immunophenotype with special emphasis on CD56 expression and CD4/CD8 status. " 03/01/2010 - "The histopathological examination of the surgical specimen, showed a large lymphoma cells with angioinvasion expressing CD3 (cytoplasmic), CD2, CD8, CD43, CD45, CD45Ro, CD56, T-cell intracellular antigen-1, perforine, Mib1 and granzyme. " 10/01/2005 - "Immunohistochemically, lymphoma cells were CD8+, CD4-, granzyme B+, and T-cell intracellular antigen-1 (TIA-1)+, showing a cytotoxic T-cell phenotype. "
3.	T-Cell Lymphoma (Lymphoma, T Cell) 12/01/2008 - "Further studies revealed that the cells were CD56+, T-cell-restricted intracellular antigen-1+, and contained Epstein-Barr virus sequences consistent with a nasal-type NK/T-cell lymphoma. " 10/01/1999 - "[Epstein-Barr virus infection and expression of T-cell intracellular antigen-1 (TIA-1) in intestinal T-cell lymphoma]." 03/01/2001 - "Nasal NK-cell lymphomas and intestinal T-cell lymphomas had fine azurophilic granules and displayed dot-like immunostaining of granzyme B- and T-cell intracellular antigen 1 (TIA-1), predominantly in the central area of the cytoplasm. " 04/01/2008 - "The tumour cells had a typical phenotype of nasal NK/T-cell lymphoma: CD2+, CD3epsilon+, CD4-, CD5-, CD56+, T-cell intracellular antigen-1+, granzyme B+, perforin+ and EBV+. However, four of six cases demonstrated clonal T-cell receptor gamma-gene rearrangement on polymerase chain reaction analysis, unlike nasal NK/T-cell lymphoma. "
4.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 02/01/1997 - "The purpose of this study was to investigate the expression of perforin and T-cell intracellular antigen-1, two crucial components of lymphocyte-mediated cytotoxicity, in endomyocardial biopsies from patients with idiopathic dilated cardiomyopathy. "
5.	Aplastic Anemia (Anemia, Hypoplastic) 03/01/2003 - "To study the involvement of cytotoxic granules in apoptosis of aplastic anaemia (AA), we analysed bone marrow clot sections of AA for apoptosis and perforin, granzyme B and T-cell intracellular antigen-1 (TIA-1) expression. "

Related Drugs and Biologics

1.	Granzymes (Granzyme)
2.	Perforin
3.	perforin-granzyme B
4.	Proteins (Proteins, Gene)
5.	T-Cell Antigen Receptors (T-Cell Receptor)
6.	RNA-Binding Proteins (RNA-Binding Protein)
7.	RNA (Ribonucleic Acid)
8.	Antigens
9.	Tryptases (Tryptase)
10.	Tristetraprolin

Related Therapies and Procedures

1.	Therapeutics