We report a 76-year-old woman with extra nodal NK/
T-cell lymphoma nasal type (ENKL). She had large
tumors on her left leg with inguinal
lymphadenopathy and gastric
tumors. The
tumor cells showed angiocentric growth with
necrosis. Immunohistologically, the
tumor cells from the skin lesion expressed CD2, cytoplasmic CD3, CD56, and
T-cell intracellular antigen-1 (TIA-1), but not surface CD3, CD19, and TdT. The gastric
tumor cell, also expressed cytoplasmic CD3, CD45RO and CD56. She was diagnosed as having ENKL (stage IV of Ann Arbor). The
tumors responded remarkably well to
radiation therapy followed by multi-drug resistance independent DeVIC (
carboplatin,
etoposide,
ifosfamide, and
dexamethasone) combination
therapy. After two series of this
therapy, no
tumors were detected in clinical, histopathological,
endoscope and computerized tomogram (CT) examinations. However, she suddenly died of brain stem
metastasis three months later. Although there may be a limitation of effects on
metastasis of
tumors in the central nervous system, radiation and DeVIC combination
therapy is a potent therapeutic method for ENKL.