Histone Deacetylase 6

A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.

Networked: 322 relevant articles (11 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kozikowski, Alan P: 11 articles (01/2021 - 11/2012)
2.	Van Den Bosch, Ludo: 8 articles (01/2021 - 08/2012)
3.	Liou, Jing-Ping: 7 articles (01/2021 - 05/2014)
4.	Shen, Sida: 7 articles (01/2021 - 02/2016)
5.	Alam, Hasan B: 7 articles (11/2020 - 07/2015)
6.	Li, Yongqing: 7 articles (11/2020 - 07/2015)
7.	Liu, Na: 6 articles (01/2022 - 01/2017)
8.	Benoy, Veronick: 6 articles (01/2021 - 08/2012)
9.	Zhou, Jun: 6 articles (01/2020 - 11/2013)
10.	Liu, Baoling: 6 articles (01/2019 - 07/2015)

Related Diseases

1.	Cystic Fibrosis (Mucoviscidosis) 01/01/2017 - "Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6." 10/01/2022 - "The circadian system in cystic fibrosis mice is regulated by histone deacetylase 6." 12/05/2022 - "Efficacy of selective histone deacetylase 6 inhibition in mouse models of Pseudomonas aeruginosa infection: A new glimpse for reducing inflammation and infection in cystic fibrosis." 03/22/2005 - "Cellular studies show that endogenous AT3 colocalizes with aggresomes and preaggresome particles of the misfolded cystic fibrosis transmembrane regulator (CFTR) mutant CFTRDeltaF508 and associates with histone deacetylase 6 and dynein, proteins required for aggresome formation and transport of misfolded protein. "
2.	Acute Liver Failure (Fulminant Hepatic Failure) 09/01/2020 - "Histone deacetylase 6 inhibitor ACY1215 ameliorates mitochondrial dynamic and function injury in hepatocytes by activating AMPK signaling pathway in acute liver failure mice." 12/01/2019 - "The purpose of the present study was to elucidate the protective effect of histone deacetylase 6 inhibitor ACY1215 on autophagy pathway in acute liver failure (ALF). " 01/01/2021 - "The aim of this article is to investigate the role of histone deacetylase 6 (HDAC6) in the M1 macrophage glycolysis pathway during acute liver failure (ALF). " 01/01/2021 - "Histone Deacetylase 6 Regulates the Activation of M1 Macrophages by the Glycolytic Pathway During Acute Liver Failure." 12/01/2019 - "Histone deacetylase 6 inhibitor ACY1215 could protect acute liver failure mice and L02 cell by inhibiting apoptosis pathway through enhancing autophagy way."
3.	Leukemia 12/29/2018 - "Histone deacetylase 6 inhibition is considered as a potential therapeutic strategy for acute leukemia, since it is observed that HDAC6 is overexpressed in acute leukemia and regulates tumor survival. " 12/29/2018 - "In order to improve efficacy of chemotherapy agents of acute leukemia, this study will investigate the effects of combination MPT0G211, a novel histone deacetylase 6 inhibitor, with doxorubicin or vincristine on human acute leukemia cells. " 01/01/2017 - "The epigenetic regulation of genes in cancer could be targeted by inhibiting Histone deacetylase 6 (HDAC6), an enzyme involved in several types of cancer such as lymphoma, leukemia, ovarian cancer, etc. Through in silico methods, a set of Phenyl butyric acid derivatives with possible HDAC6 inhibitory activity were designed, rendering monophenylamides and biphenylamides using tubacin (HDAC6 selective inhibitor) as reference. "
4.	Colitis 06/01/2017 - "A Highly Potent and Selective Histone Deacetylase 6 Inhibitor Prevents DSS-Induced Colitis in Mice." 12/01/2020 - "Novel Histone Deacetylase 6 Inhibitor CKD-506 Inhibits NF-κB Signaling in Intestinal Epithelial Cells and Macrophages and Ameliorates Acute and Chronic Murine Colitis." 12/01/2020 - "CKD-506 is a novel isoform-selective inhibitor of histone deacetylase 6. The present study was performed to evaluate the effect of CKD-506 on the NF-κB signaling pathway in intestinal epithelial cells (IECs) and macrophages and on murine models of acute and chronic colitis. "
5.	Alzheimer Disease (Alzheimer's Disease) 11/21/2023 - "Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology." 12/15/2021 - "Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020)." 12/05/2021 - "Histone deacetylase 6 (HDAC6) is a potential target for Alzheimer's disease (AD). " 12/05/2021 - "Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease." 01/01/2018 - "5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes."

Related Drugs and Biologics

1.	Vincristine (Oncovin)
2.	tubastatin A
3.	Doxorubicin (Adriamycin)
4.	CKD-506
5.	MPT0G211
6.	Histone Deacetylases (Histone Deacetylase)
7.	Butyrylcholinesterase
8.	SW-100
9.	aceroside VIII
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Punctures
4.	Ligation
5.	Immunotherapy