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MPT0G211

HDAC6 inhibitor

Also Known As:

N-hydroxy-4-((quinolin-8-ylamino)methyl)benzamide

Networked: 3 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liou, Jing-Ping: 3 articles (01/2019 - 01/2018)
2.	Yang, Chia-Ron: 3 articles (01/2019 - 01/2018)
3.	Pan, Shiow-Lin: 2 articles (01/2019 - 12/2018)
4.	Tu, Huang-Ju: 2 articles (01/2019 - 12/2018)
5.	Hsieh, Yi-Ling: 1 article (01/2019)
6.	Chao, Min-Wu: 1 article (12/2018)
7.	Chen, Yi-Ying: 1 article (12/2018)
8.	Lin, Mei-Hsiang: 1 article (12/2018)
9.	Lin, Yi-Jyun: 1 article (12/2018)
10.	Sung, Ting-Yi: 1 article (12/2018)

Related Diseases

1.	Leukemia 12/29/2018 - "The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells." 12/29/2018 - "Collectively, our data highlighted that MPT0G211 in combination with chemotherapy drugs has significant anticancer activity, suggesting a novel strategy for the treatment of acute leukemia." 12/29/2018 - "In order to improve efficacy of chemotherapy agents of acute leukemia, this study will investigate the effects of combination MPT0G211, a novel histone deacetylase 6 inhibitor, with doxorubicin or vincristine on human acute leukemia cells. "
2.	Alzheimer Disease (Alzheimer's Disease) 01/01/2018 - "The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model."
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/29/2018 - "Moreover, co-treatment of MPT0G211 and vincristine may alter microtubule dynamics, triggering acute lymphoblastic leukemia cells arrest in mitotic phase followed by induction of the apoptotic pathway. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/29/2018 - "MPT0G211 combined with doxorubicin induces DNA damage response on human acute myeloid leukemia cells. "
5.	Neoplasms (Cancer) 12/29/2018 - "Finally, MPT0G211 plus doxorubicin or vincristine can significantly improve the tumor growth delay in a tumor xenograft model. "

Related Drugs and Biologics

1.	Vincristine (Oncovin)
2.	Doxorubicin (Adriamycin)
3.	Histone Deacetylase 6
4.	Histones (Histone)
5.	Acetylesterase

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)