Copper-Transporting ATPases

P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.

Also Known As:

ATP7A Protein; ATPase Copper Transporting alpha; Copper Pump 1; PINA Enzyme; Wilson Disease Protein; ATP7B Cu Binding P Type ATPase; ATPase 1, Copper-Transporting; ATPase 2, Copper-Transporting; ATPase, Copper-Transporting; ATPase, Pineal Night-Specific; ATPases, Copper-Transporting; ATPases, Cu-Transporting; Adenosine Triphosphatases, Copper-Transporting; Copper Transporting ATPase; Copper Transporting ATPase 1; Copper Transporting ATPase 2; Copper Transporting ATPases; Copper Transporting Adenosine Triphosphatases; Cu Transporting ATPases; Menkes Disease Associated Protein; Night-Specific ATPase, Pineal; Pineal Night Specific ATPase; Triphosphatases, Copper-Transporting Adenosine; Wilson Disease Cu Binding P Type ATPase; ATP7B Cu-Binding P Type ATPase; ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease); Copper-Transporting ATPase; Copper-Transporting ATPase 1; Copper-Transporting ATPase 2; Copper-Transporting Adenosine Triphosphatases; Cu(+)-Transporting ATPases; Cu-Transporting ATPases; Menkes Disease-Associated Protein; Pineal Night-Specific ATPase; Wilson Disease Cu-Binding P Type ATPase

Networked: 142 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lutsenko, Svetlana: 11 articles (07/2017 - 01/2002)
2.	Kaler, Stephen G: 7 articles (01/2020 - 08/2009)
3.	Tsivkovskii, Ruslan: 7 articles (03/2005 - 01/2002)
4.	Petris, Michael J: 5 articles (12/2019 - 10/2007)
5.	Efremov, Roman G: 4 articles (08/2004 - 10/2002)
6.	Huster, Dominik: 3 articles (01/2017 - 08/2003)
7.	Holmes, Courtney S: 3 articles (01/2013 - 08/2009)
8.	Walker, Joel M: 3 articles (04/2004 - 10/2002)
9.	Cox, Diane W: 3 articles (03/2004 - 10/2002)
10.	Wang, Yanfang: 2 articles (12/2019 - 12/2012)

Related Diseases

1.	Hepatolenticular Degeneration (Wilson's Disease) 12/15/2023 - "Wilson disease is caused by pathogenic variants in the ATP7B gene which encodes a copper-transporting ATPase. " 02/27/2023 - "Wilson's disease (WD) is a rare autosomal recessive (AR) disorder resulting from mutations in the ATP7B gene, which is responsible for the encryption of transmembrane copper transporting ATPase. " 01/01/2018 - "Wilson disease (WD) is an autosomal-recessive disease caused by mutations in the ATP7B gene which encodes a copper-transporting ATPase. " 01/01/2015 - "The Wilson disease gene, a copper transporting ATPase (Atp7b), is responsible for the sequestration of Cu into secretory vesicles, and this function is exhibited by the orthologous Ccc2p in the yeast. " 09/01/2014 - "ATP7B is one of two copper-transporting ATPases in humans, its vital role being manifested in Wilson disease due to a mutation in the gene that encodes this pump. "
2.	Fibrosis (Cirrhosis) 04/01/2015 - "Experimental studies in mutant mice in which the copper-transporting ATPase gene (Atp7b) is disrupted revealed a drastic, time-dependent accumulation of hepatic copper that is accompanied by formation of regenerative nodes resembling cirrhosis. " 08/01/2011 - "Nearly a century after Dr. Samuel Alexander Kinnier Wilson composed his doctoral thesis on the pathologic findings of "lenticular degeneration" in the brain associated with cirrhosis of the liver we know that the underlying molecular basis for this autosomal recessive inherited disorder that now bears his name is mutation of a copper transporting ATPase, ATP7B, an intracellular copper transporter mainly expressed in hepatocytes. "
3.	Esophageal Neoplasms (Esophageal Cancer) 01/01/2021 - "In this study, we investigated the possible regulation of 1 copper ion transporter (ATP7A; ATPase copper transporting alpha) by microRNA miR-495 and its implications in cisplatin resistance and angiogenesis in esophageal cancer. "
4.	Menkes Kinky Hair Syndrome (Menkes Disease) 01/01/2017 - "Menkes disease is a severe X-linked recessive disorder caused by a defect in the ATP7A gene, which encodes a membrane copper-transporting ATPase. " 08/01/2009 - "Menkes disease is an X-linked recessive disorder characterized by a copper-transporting ATPase defect. " 10/01/2007 - "Phenotypic diversity of Menkes disease in mottled mice is associated with defects in localisation and trafficking of the ATP7A protein." 02/01/2005 - "The gene for Menkes disease has been isolated and predicted to code for copper transporting ATPase. " 10/01/2001 - "Menkes disease (MNK) is an X-linked recessive disorder characterised by a copper-transporting ATPase defect. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2020 - "Menkes disease is an X-linked neurodegenerative disease caused by mutation in ATP7A gene, which codes for copper-transporting ATPase. " 01/01/2014 - "Menkes disease (OMIM: 309400) is considered a rare, X-linked recessive neurodegenerative disorder resulting from a mutation in the gene coding for the copper transporting ATPase (ATP7A). " 01/01/2013 - "Classical Menkes disease is a neurodegenerative disorder caused by mutations in the copper-transporting ATPase ATP7A gene which, when untreated, is usually fatal in early childhood. " 11/01/2011 - "Menkes disease, an X linked recessive neurodegenerative disorder, results from a mutation in the gene coding for the copper transporting ATPase (ATP7A). " 04/01/2011 - "Menkes disease (MD) is an infantile-onset X-linked recessive neurodegenerative disorder caused by deficiency or dysfunction of a copper-transporting ATPase, ATP7A. "

Related Drugs and Biologics

1.	Copper
2.	Cisplatin (Platino)
3.	MicroRNAs (MicroRNA)
4.	Calcium-Transporting ATPases (Ca2+ ATPase)
5.	Proteins (Proteins, Gene)
6.	Metals
7.	P-type ATPases
8.	Ceruloplasmin (Ferroxidase)
9.	Peptides (Polypeptides)
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics