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Cytochrome P450 Family 27

A cytochrome P450 enzyme family whose members function in VITAMIN D metabolism and the biosynthesis of BILE ACIDS.

Also Known As:

CYP27 Enzymes; CYP27 Family

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lai, Hua: 1 article (12/2022)
2.	Liu, Huai: 1 article (12/2022)
3.	Liu, Xianxian: 1 article (12/2022)
4.	Xin, Siming: 1 article (12/2022)
5.	Xiong, Ying: 1 article (12/2022)
6.	Zeng, Xiaoming: 1 article (12/2022)
7.	Zeng, Yang: 1 article (12/2022)
8.	Zheng, Jiusheng: 1 article (12/2022)
9.	Zhou, Mengni: 1 article (12/2022)
10.	Zou, Yang: 1 article (12/2022)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 08/01/2018 - "The present study revealed that in glioblastoma cells, the overexpression of cytochrome P450, family 27, subfamily A, polypeptide 1 (CYP27A1) promoted proliferation, while silencing of CYP27A1 inhibited proliferation, without affecting migration and invasion. "
2.	Rickets (Rachitis) 12/01/2022 - "Vitamin D-dependent rickets (VDDR) type 1A is a rare autosomal recessive disorder caused by cytochrome P450 family 27 subfamily B member 1 (CYP27B1) mutations and can lead to deficiencies in 1α-hydroxylase activity. " 03/01/2023 - "Vitamin D-dependent rickets type 1 (VDDRIA) is an autosomal recessive disorder caused by mutations in the Cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1) gene, which encodes for the enzyme 1 alpha-hydroxylase. "
3.	Neoplasms (Cancer) 10/01/2018 - "This is supported by the significantly higher expression of CYP27A1 (cytochrome P450, family 27, subfamily A, polypeptide 1) in breast cancers. " 11/01/2020 - "We analyzed the expression of vitamin D receptor (VDR), cytochrome P450 family 27 subfamily B member 1 (CYP27B1) and cytochrome P450 family 24 subfamily A member 1 (CYP24A1), the key genes involved in vitamin D signaling, in kidneys from patients with ESRD, tissue microarrays containing ESRD-associated renal cell tumors, as well as in their precursor lesions by immunohistochemistry. "
4.	Cerebrotendinous Xanthomatosis 01/01/2023 - "Cerebrotendinous xanthomatosis (CTX), also known as CTX, is an extremely rare bile acid metabolic disorder caused by mutations in the cytochrome P450 family 27 subfamily A member 1 (CYP27A1) gene. "
5.	Lung Neoplasms (Lung Cancer) 12/01/2017 - "Aberrant expression of the essential enzyme encoding genes, Cytochrome P450 Family 27 Subfamily A Member 1 (CYP27A1), Cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1), and Cytochrome P450 Family 24 Subfamily A Member 1 (CYP24A1) may be associated with lung cancer. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)
3.	Vitamin D
4.	Vitamin D3 24-Hydroxylase
5.	Enzymes
6.	Bile Acids and Salts (Bile Acids)
7.	Cytochrome P450 Family 24
8.	Calcitriol Receptors (Calcitriol Receptor)
9.	Mixed Function Oxygenases (Monooxygenases)